Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution

Analytical Chemistry

Volumn 81, Issue 14, 2009, Pages 5593-5602

  Piehowski, Paul D ^a   Davey, Angel M ^a   Kurczy, Michael E ^a   Sheets, Erin D ^a   Winograd, Nicholas ^a   Ewing, Andrew G ^a,b   Heien, Michael L ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL COMPLEXITY; BIOLOGICAL PROCESS; COUNTING STATISTICS; FIGURES OF MERITS; IMAGE FEATURES; LIMITS OF DETECTION; LOW-INTENSITY; MAST CELLS; MEMBRANE COMPONENTS; PIXEL INTENSITIES; POISSON STATISTIC; SAMPLE MATRIX; SIMS IMAGING; SPATIAL RESOLUTION; SPOT SIZES; SUB-CELLULAR; TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY; TOF-SIMS IMAGING;

CELL MEMBRANES; CYTOLOGY; IMAGE RESOLUTION; MASS SPECTROMETERS; NEGATIVE IONS; PIXELS; POISSON DISTRIBUTION; POISSON EQUATION; SECONDARY EMISSION; SOIL STRUCTURE INTERACTIONS; SPECTROMETRY;

SECONDARY ION MASS SPECTROMETRY;

ANIMAL CELL; ARTICLE; CELL ASSAY; CONTROLLED STUDY; IMAGE ANALYSIS; IMAGE QUALITY; MAST CELL; MATHEMATICAL MODEL; NONHUMAN; OPTICAL RESOLUTION; POISSON DISTRIBUTION; RAT; SIGNAL DETECTION; TIME OF FLIGHT MASS SPECTROMETRY; VALIDATION STUDY;

ANIMALS; CELL LINE; CELL MEMBRANE; CHOLESTEROL; INTRACELLULAR SPACE; LIPID METABOLISM; LIPIDS; MASS SPECTROMETRY; MAST CELLS; POISSON DISTRIBUTION; PROBABILITY; SURFACE PROPERTIES;

EID: 67650725816     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901065s     Document Type: Article

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