메뉴 건너뛰기




Volumn 33, Issue 3, 2009, Pages 125-133

Dabigatran and rivaroxaban, new oral anticoagulants for the treatment of venous thromboembolism;Farmacocinética y farmacodinamia de los nuevos anticoagulantes orales

Author keywords

Anticoagulants; Direct factor Xa inhibitors; Direct thrombin inhibitors; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; APIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CLARITHROMYCIN; CLOPIDOGREL; CYTOCHROME P450; CYTOCHROME P450 3A4; DABIGATRAN; DABIGATRAN ETEXILATE; DIGOXIN; ENOXAPARIN; FONDAPARINUX; GLYCOPROTEIN P INHIBITOR; HEPARIN; HIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; MELAGATRAN; NONSTEROID ANTIINFLAMMATORY AGENT; OXAZOLIDINONE DERIVATIVE; PANTOPRAZOLE; RANITIDINE; RIFAMPICIN; RIVAROXABAN; SERINE PROTEINASE; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG; VERAPAMIL; WARFARIN; XARELTO; XIMELAGATRAN;

EID: 67650723217     PISSN: 11306343     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1130-6343(09)71154-7     Document Type: Editorial
Times cited : (20)

References (43)
  • 1
    • 4544226466 scopus 로고    scopus 로고
    • New anticoagulants for treatment of venous thromboembolism
    • J.I. Weitz New anticoagulants for treatment of venous thromboembolism Circulation 110 Suppl I 2004 I19 26
    • (2004) Circulation , vol.110 , Issue.SUPPL I , pp. 19-26
    • Weitz, J.I.1
  • 2
    • 14544275123 scopus 로고    scopus 로고
    • New anticoagulant therapy
    • DOI 10.1146/annurev.med.56.082103.104708
    • L.A. Linkins, and J.I. Weitz New anticoagulant therapy Annu Rev Med 56 2005 63 77 (Pubitemid 40299774)
    • (2005) Annual Review of Medicine , vol.56 , pp. 63-77
    • Linkins, L.-A.1    Weitz, J.I.2
  • 3
    • 11244337244 scopus 로고    scopus 로고
    • New anticoagulants
    • DOI 10.1182/blood-2003-12-4195
    • J. Hirsh, M. O'Donnell, and J.I. Weitz New Anticoagulants Blood 105 2005 453 463 (Pubitemid 40070721)
    • (2005) Blood , vol.105 , Issue.2 , pp. 453-463
    • Hirsh, J.1    O'Donneill, M.2    Weitz, J.I.3
  • 4
    • 31644439066 scopus 로고    scopus 로고
    • Venous thromboembolism
    • DOI 10.1136/bmj.332.7535.215
    • A.D. Blann, and G.Y.H. Lip Venous thromboembolism BMJ 332 2006 215 219 (Pubitemid 43171703)
    • (2006) British Medical Journal , vol.332 , Issue.7535 , pp. 215-219
    • Blann, A.D.1    Lip, G.Y.H.2
  • 5
    • 34250901454 scopus 로고    scopus 로고
    • Latest medical treatment strategies for venous thromboembolism
    • DOI 10.1517/14656566.8.9.1221
    • J.S. McRae, and J.W. Eikelboom Latest medical treatment strategies for venous thromboembolism Expert Opin Pharmacother 8 2007 1221 1233 (Pubitemid 47038993)
    • (2007) Expert Opinion on Pharmacotherapy , vol.8 , Issue.9 , pp. 1221-1233
    • McRae, S.J.1    Eikelboom, J.W.2
  • 6
    • 34547536841 scopus 로고    scopus 로고
    • Insufficient duration of venous thromboembolism prophylaxis after total hip or knee replacement when compared with the time course of thromboembolic events
    • DOI 10.1302/0301-620X.89B6.18844
    • Warwick D, Friedman RJ, Agnelli G, et al (from the Global Orthopaedic Registry). Insuffi cient duration of venous thromboembolism prophylaxis after total hip or knee replacement when compared with the time course of thromboembolic events. J Bone Joint Surg Br. 2007;89-B:799-807 (Pubitemid 47180202)
    • (2007) Journal of Bone and Joint Surgery - Series B , vol.89 , Issue.6 , pp. 799-807
    • Warwick, D.1    Friedman, R.J.2    Agnelli, G.3    Gil-Garay, E.4    Johnson, K.5    FitzGerald, G.6    Turibio, F.M.7
  • 7
    • 17844385569 scopus 로고    scopus 로고
    • New anticoagulants: Beyond heparin, low-molecular-weight heparin and warfarin
    • DOI 10.1038/sj.bjp.0706153
    • S.M. Bates, and J.I. Weitz New anticoagulants beyond heparin, low-molecular-weight heparin and warfarin Br J Pharmacol 144 2005 1017 1028 (Pubitemid 40592999)
    • (2005) British Journal of Pharmacology , vol.144 , Issue.8 , pp. 1017-1028
    • Bates, S.M.1    Weitz, J.I.2
  • 9
    • 45949083155 scopus 로고    scopus 로고
    • New antithrombotic drugs (American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th Edition)
    • J.I. Weitz, J. Hirsh, and M.M. Samama New antithrombotic drugs (American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th Edition) Chest 133 2008 234 256
    • (2008) Chest , vol.133 , pp. 234-256
    • Weitz, J.I.1    Hirsh, J.2    Samama, M.M.3
  • 11
    • 33947104111 scopus 로고    scopus 로고
    • Beyond heparin and warfarin: The new generation of anticoagulants
    • DOI 10.1517/13543784.16.3.271
    • J.I. Weitz, and L.A. Linkins Beyond heparin and warfarin: the new generation of anticoagulants Expert Opin Investig Drugs 16 2007 271 282 (Pubitemid 46394852)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.3 , pp. 271-282
    • Weitz, J.I.1    Linkins, L.-A.2
  • 14
  • 15
    • 24944536065 scopus 로고    scopus 로고
    • Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3-[4- (3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide (BAY 59-7939): An oral, direct factor Xa inhibitor
    • DOI 10.1021/jm050101d
    • S. Roehrig, A. Straub, J. Pohlmann, T. Lampe, J. Pernerstorfer, and K.H. Schlemmer Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl] -1,3-oxazolidin-5-yl}methyl)thiophene-2- carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor J Med Chem 48 2005 5900 5908 (Pubitemid 41324601)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.19 , pp. 5900-5908
    • Roehrig, S.1    Straub, A.2    Pohlmann, J.3    Lampe, T.4    Pernerstorfer, J.5    Schlemmer, K.-H.6    Reinemer, P.7    Perzborn, E.8
  • 17
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • DOI 10.1111/j.1538-7836.2007.02764.x
    • M.R. Lassen, B.L. Davidson, A. Gallus, G. Pineo, J. Ansell, and D. Deitchman The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement J Thromb Haemost 5 2007 2368 2375 (Pubitemid 350154345)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.12 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.6
  • 18
    • 0008348082 scopus 로고    scopus 로고
    • European Medicines Agency (EMEA) Pradaxa H-C-829 citado 17 Mar 2009. Disponible en
    • European Medicines Agency (EMEA) Pradaxa H-C-829. European Public Assessment Report. Revision 2. 2009 [citado 17 Mar 2009]. Disponible en: http://www.emea.europa.eu/humandocs/PDFs/EPAR/pradaxa/H-829-en6.pdf
    • (2009) European Public Assessment Report. Revision 2
  • 19
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • J. Stangier Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate Clin Pharmacokinet 47 2008 285 295
    • (2008) Clin Pharmacokinet , vol.47 , pp. 285-295
    • Stangier, J.1
  • 20
    • 0008348082 scopus 로고    scopus 로고
    • European Medicines Agency (EMEA) Xarelto H-C-944 [citado 19 mar 2009]. Disponible en
    • European Medicines Agency (EMEA) Xarelto H-C-944. European Public Assessment Report. Revision 1. 2009 [citado 19 mar 2009]. Disponible en: http://www.emea.europa.eu/humandocs/PDFs/EPAR/xarelto/H-944-en6.pdf
    • (2009) European Public Assessment Report. Revision 1
  • 24
    • 34250755638 scopus 로고    scopus 로고
    • Factor Xa or thrombin: Is thrombin a better target?
    • DOI 10.1111/j.1538-7836.2007.02552.x, State of the Art 2007: XXI Congress of the International Society on Thrombosis and Haemostasis
    • J.I. Weitz Factor Xa or thrombin: is thrombin a better target? J Thromb Haemost 5 Suppl 1 2007 65 67 (Pubitemid 46958818)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.SUPPL. 1 , pp. 65-67
    • Weitz, J.I.1
  • 26
    • 34147147085 scopus 로고    scopus 로고
    • In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban [13]
    • DOI 10.1111/j.1538-7836.2007.02429.x
    • G.T. Gerotziafas, I. Elalamy, F. Depasse, E. Perzborn, and M.M. Samama In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban J Thromb Haemost 5 2007 886 888 (Pubitemid 46563600)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.4 , pp. 886-888
    • Gerotziafas, G.T.1    Elalamy, I.2    Depasse, F.3    Perzborn, E.4    Samama, M.M.5
  • 27
    • 35448932027 scopus 로고    scopus 로고
    • Effects of the oral, direct factor Xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    • DOI 10.1177/0091270007302952
    • J. Graff, H.N. Von, F. Misselwitz, D. Kubitza, M. Becka, and H.K. Breddin Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity J Clin Pharmacol 47 2007 1398 1407 (Pubitemid 47624591)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.11 , pp. 1398-1407
    • Graff, J.1    Von Hentig, N.2    Misselwitz, F.3    Kubitza, D.4    Becka, M.5    Breddin, H.-K.6    Harder, S.7
  • 28
    • 34447522035 scopus 로고    scopus 로고
    • In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    • DOI 10.1160/TH07-03-0183
    • W. Wienen, J.M. Stassen, H. Priepke, U.J. Ries, and N. Hauel In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate Thromb Haemost 98 2007 155 162 (Pubitemid 47078782)
    • (2007) Thrombosis and Haemostasis , vol.98 , Issue.1 , pp. 155-162
    • Wienen, W.1    Stassen, J.-M.2    Priepke, H.3    Ries, U.J.4    Hauel, N.5
  • 29
    • 34250030035 scopus 로고    scopus 로고
    • Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis
    • DOI 10.1111/j.1538-7836.2007.02526.x
    • W. Wienen, J.M. Stassen, H. Priepke, U.J. Ries, and N. Hauel Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis J Thromb Haemost 5 2007 1237 1242 (Pubitemid 46902126)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.6 , pp. 1237-1242
    • Wienen, W.1    Stassen, J.-M.2    Priepke, H.3    Ries, U.J.4    Hauel, N.5
  • 30
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • DOI 10.1016/j.clpt.2005.06.011, PII S000992360500281X
    • D. Kubitza, M. Becka, B. Voith, M. Zuehlsdorf, and G. Wensing Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor Clin Pharmacol Ther 78 2005 412 421 (Pubitemid 41393676)
    • (2005) Clinical Pharmacology and Therapeutics , vol.78 , Issue.4 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 31
    • 17644400166 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    • DOI 10.1177/0091270005274550
    • J. Stangier, B.I. Eriksson, O.E. Dahl, L. Ahnfelt, G. Nehmiz, and H. Stahle Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement J Clin Pharmacol 45 2005 555 563 (Pubitemid 40562946)
    • (2005) Journal of Clinical Pharmacology , vol.45 , Issue.5 , pp. 555-563
    • Stangier, J.1    Eriksson, B.I.2    Dahl, O.E.3    Ahnfelt, L.4    Nehmiz, G.5    Stahle, H.6    Rathgen, K.7    Svard, R.8
  • 33
    • 10844233894 scopus 로고    scopus 로고
    • The ecarin clotting time, a universal method to quantify direct thrombin inhibitors
    • DOI 10.1159/000081505
    • G. Nowak The ecarin clotting time, a universal method to quantify direct thrombin inhibitors Pathophysiol Haemost Thromb 33 2003 173 183 (Pubitemid 39664135)
    • (2003) Pathophysiology of Haemostasis and Thrombosis , vol.33 , Issue.4 , pp. 173-183
    • Nowak, G.1
  • 34
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • DOI 10.1177/0091270006296058
    • D. Kubitza, M. Becka, M. Zuehlsdorf, and W. Mueck Body weight has limited infl uence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects J Clin Pharmacol 47 2007 218 226 (Pubitemid 46146488)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.2 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 35
    • 42949123582 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of rivaroxaban - An oral, direct factor Xa inhibitor - In patients undergoing major orthopaedic surgery
    • W. Mueck, B.I. Eriksson, K.A. Bauer, L. Borris, O.E. Dahl, and W.D. Fisher Population pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct factor Xa inhibitor - in patients undergoing major orthopaedic surgery Clin Pharmacokinet 47 2008 203 216
    • (2008) Clin Pharmacokinet , vol.47 , pp. 203-216
    • Mueck, W.1    Eriksson, B.I.2    Bauer, K.A.3    Borris, L.4    Dahl, O.E.5    Fisher, W.D.6
  • 36
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    • D. Kubitza, M. Becka, M. Zuehlsdorf, and W. Mueck Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects J Clin Pharmacol 46 2006 549 558
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 37
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • DOI 10.1124/dmd.107.019083
    • S. Blech, T. Ebner, E. Ludwig-Schwellinger, J. Stangier, and W. Roth The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans Drug Metab Dispos 36 2008 386 399 (Pubitemid 351185753)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.2 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Roth, W.5
  • 38
    • 33847094672 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR 1048) in patients undergoing primary elective total hip replacement surgery
    • DOI 10.1177/0091270006297228
    • I.F. Trocóniz, C. Tillmann, K.H. Liesenfeld, H.G. Schäfer, and J. Stangier Population pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR 1048) in patients undergoing primary elective total hip replacement surgery J Clin Pharmacol 47 2007 371 382 (Pubitemid 46294714)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.3 , pp. 371-382
    • Troconiz, I.F.1    Tillmann, C.2    Liesenfeld, K.-H.3    Schafer, H.-G.4    Stangier, J.5
  • 39
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • DOI 10.1111/j.1365-2125.2007.02899.x
    • J. Stangier, K. Rathgen, H. Stähle, D. Gansser, and W. Roth The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects Br J Clin Pharmacol 64 2007 292 303 (Pubitemid 47283865)
    • (2007) British Journal of Clinical Pharmacology , vol.64 , Issue.3 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 40
    • 34547097409 scopus 로고    scopus 로고
    • Effects of renal impairment on the pharmacology of rivaroxaban (BAY 59-7939), an oral, direct factor Xa inhibitor
    • A. Halabi, H. Maatouk, and N. Klause Effects of renal impairment on the pharmacology of rivaroxaban (BAY 59-7939), an oral, direct factor Xa inhibitor Blood 108 2006 Abstract 913. ASH Annual Meeting
    • (2006) Blood , vol.108
    • Halabi, A.1    Maatouk, H.2    Klause, N.3
  • 42
    • 33947205635 scopus 로고    scopus 로고
    • Rivaroxaban (BAY 59-7939) - An oral, direct Factor Xa inhibitor - Has no clinically relevant interaction with naproxen
    • DOI 10.1111/j.1365-2125.2006.02776.x
    • D. Kubitza, M. Becka, W. Mueck, and M. Zuehlsdorf Rivaroxaban (BAY 59-7939) - an oral, direct Factor Xa inhibitor - has no clinically relevant interaction with naproxen Br J Clin Pharmacol 63 2007 469 476 (Pubitemid 46426627)
    • (2007) British Journal of Clinical Pharmacology , vol.63 , Issue.4 , pp. 469-476
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 43
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - An oral, direct factor Xa inhibitor - Are not affected by aspirin
    • DOI 10.1177/0091270006292127
    • D. Kubitza, M. Becka, W. Mueck, and M. Zuehlsdorf Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - -an oral, direct factor Xa inhibitor - are not affected by aspirin J Clin Pharmacol 46 2006 981 990 (Pubitemid 44215062)
    • (2006) Journal of Clinical Pharmacology , vol.46 , Issue.9 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.