Effect of phosphorylated hsp27 on proliferation of human endothelial and smooth muscle cells

Proteomics

Volumn 9, Issue 12, 2009, Pages 3383-3394

  Trott, Deborah ^a   McManus, Ciara A ^b   Martin, Jody L ^c   Brennan, Bryony ^d   Dunn, Michael J ^b   Rose, Marlene L ^a  

^a HAREFIELD HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Atherosclerosis; Endothelial cells; Hsp27 kDa; Smooth muscle cells; Transplant graft vasculopathy

Indexed keywords

CELL CYCLE PROTEIN; COFILIN; DNA; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEASOME; STATHMIN; TELOMERASE REVERSE TRANSCRIPTASE; TRYPSIN; UBIQUITIN;

ADENOVIRUS; AMINO ACID SEQUENCE; AORTA; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME SUBUNIT; FLOW CYTOMETRY; GRAFT FAILURE; GRAFT VASCULOPATHY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS; UBIQUITINATION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ATHEROSCLEROSIS; BLOTTING, WESTERN; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MUSCLE, SMOOTH; MUTATION; PHOSPHORYLATION; PROTEOME; REPRODUCIBILITY OF RESULTS;

ADENOVIRIDAE;

EID: 67650713696     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200800961     Document Type: Article

References (29)

1. Fink, A. L., Chaperone-mediated protein folding. Physiol. Rev. 1999, 79, 425-449.
2. Efthymiou, C. A., Mocanu, M. M., de Belleroche, J., Wells, D. J. et al., Heat shock protein 27 protects the heart against myocardial infarction. Basic Res. Cardiol. 2004, 99, 392-394.
3. Hollander, J. M., Martin, J. L., Belke, D. D., Scott, B. T. et al., Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation 2004, 110, 3544-3552.
4. De Souza, A. I., Wait, R., Mitchell, A. G., Banner, N. R. et al., Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation. Circ. Res. 2005, 97, 192-198.
5. Martin-Ventura, J. L., Duran, M. C., Blanco-Colio, L. M., Meilhac, O. et al., Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis. Circulation 2004, 110, 2216-2219.
6. Park, H. K., Park, E. C., Bae, S. W., Park, M. Y. et al., Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome. Circulation 2006, 114, 886-893.
7. Rayner, K., Chen, Y. X., McNulty, M., Simard, T. et al., Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A. Circ. Res. 2008, 103, 133-141.
8. Concannon, C. G., Gorman, A. M., Samali, A., On the role of Hsp27 in regulating apoptosis. Apoptosis 2003, 8, 61-70.
9. Merendino, A. M., Paul, C., Vignola, A. M., Costa, M. A. et al., Heat shock protein-27 protects human bronchial epithelial cells against oxidative stress-mediated apoptosis: possible implication in asthma. Cell Stress Chaperones 2002, 7, 269-280.
10. Mounier, N., Arrigo, A. P., Actin cytoskeleton and small heat shock proteins: how do they interact? Cell Stress Chaperones. 2002, 7, 167-176.
11. Arata, S., Hamaguchi, S., Nose, K., Inhibition of colony formation of NIH 3T3 cells by the expression of the small molecular weight heat shock protein HSP27: involvement of its phosphorylation and aggregation at the C-terminal region. J. Cell. Physiol. 1997, 170, 19-26.
12. Hoefer, I. E., Timmers, L., Piek, J. J., Growth factor therapy in atherosclerotic disease - friend or foe. Curr. Pharm. Des. 2007, 13, 1803-1810.
13. Virmani, R., Kolodgie, F. D., Burke, A. P., Finn, A. V. et al., Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 2054-2061.
14. Rahmani, M., Cruz, R. P., Granville, D. J., McManus, B. M., Allograft vasculopathy versus atherosclerosis. Circ. Res. 2006, 99, 801-815.
15. McKee, J. A., Banik, S. S., Boyer, M. J., Hamad, N. M. et al., Human arteries engineered in vitro. EMBO Rep. 2003, 4, 633-638.
16. Ades, E. W., Candal, F. J., Swerlick, R. A., George, V. G. et al., HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 1992, 99, 683-690.
17. Martin, J. L., Mestril, R., Hilal-Dandan, R., Brunton, L. L. et al., Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 1997, 96, 4343-4348.
18. Alford, K. A., Glennie, S., Turrell, B. R., Rawlinson, L. et al., Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. J. Biol. Chem. 2007, 282, 6232-6241.
19. Karp, N. A., Lilley, K. S., Maximising sensitivity for detecting changes in protein expression: experimental design using minimal CyDyes. Proteomics 2005, 5, 3105-3115.
20. Rabilloud, T., Valette, C., Lawrence, J. J., Sample application by in-gel rehydration improves the resolution of two-dimensional electrophoresis with immobilized pH gradients in the first dimension. Electrophoresis 1994, 15, 1552-1558.
21. Gorg, A., Postel, W., Gunther, S., Weser, J. et al., Approach to stationary two-dimensional pattern: influence of focusing time and immobiline/carrier ampholytes concentrations. Electrophoresis 1988, 9, 37-46.
22. Yan, J. X., Wait, R., Berkelman, T., Harry, R. A.et al., A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry. Electrophoresis 2000, 21, 3666-3672.
23. Landry, J., Lambert, H., Zhou, M., Lavoie, J. N. et al., Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J. Biol. Chem. 1992, 267, 794-803.
24. Rocchi, P., Jugpal, P., So, A., Sinneman, S. et al., Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro 2. BJU Int. 2006, 98, 1082-1089.
25. Salinthone, S., Ba, M., Hanson, L., Martin, J. L. et al., Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 293, L1194-L1207.
26. Iancu, C., Mistry, S. J., Arkin, S., Wallenstein, S., Atweh, G. F., Effects of stathmin inhibition on the mitotic spindle. J. Cell. Sci. 2001, 114, 909-916.
27. Marklund, U., Larsson, N., Gradin, H. M., Brattsand, G. et al., Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics. EMBO J. 1996, 15, 5290-5298.
28. Keezer, S. M., Ivie, S. E., Krutzsch, H. C., Tandle, A. et al., Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin. Cancer Res. 2003, 63, 6405-6412.
29. Wang, Y., Bai, Y., Qin, L., Zhang, P. et al., Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation. Circ. Res. 2007, 101, 560-569.