Metal-ion mutagenesis: Conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site

Journal of the American Chemical Society

Volumn 131, Issue 23, 2009, Pages 8173-8179

  Mitić, Nataša ^a   Noble, Christopher J ^a   Gahan, Lawrence R ^a   Hanson, Graeme R ^a   Schenk, Gerhard ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ACIDIC CONDITIONS; ACTIVE SITE; ANTIFERRO-MAGNETICALLY COUPLED; CARBOXYLATO; DINUCLEAR; DIVALENT METALS; ELECTRON PARAMAGNETIC RESONANCE; EPR SPECTRA; ION CORES; KINETIC STUDY; METALLOENZYMES; NEUTRAL CONDITIONS; NEUTRAL PH; OPTIMAL ACTIVITY; OPTIMAL CONDITIONS; PURPLE ACID PHOSPHATASE; SWEET POTATO; SYSTEM MODELS;

ACIDS; ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYMES; MANGANESE COMPOUNDS; METAL IONS; METALS; MODEL STRUCTURES; PARAMAGNETIC RESONANCE; PARAMAGNETISM; QUANTUM THEORY;

MANGANESE;

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; HYDROLASE; IRON; MANGANESE; METAL ION; NUCLEOPHILE; PHOSPHATASE; GLYCOPROTEIN;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ELECTRON SPIN RESONANCE; KINETICS; MOLECULAR MODEL; MUTAGENESIS; PH; PROTEIN PURIFICATION; SWEET POTATO; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM;

ACID PHOSPHATASE; CATALYSIS; CATALYTIC DOMAIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLYCOPROTEINS; IPOMOEA BATATAS; IRON; MANGANESE; MUTAGENESIS; PHOSPHORIC MONOESTER HYDROLASES;

EID: 67650546931     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja900797u     Document Type: Article

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