An internal reaction chamber in dimethylglycine oxidase provides efficient protection from exposure to toxic formaldehyde

Journal of Biological Chemistry

Volumn 284, Issue 26, 2009, Pages 17826-17834

  Tralau, Tewes ^a   Lafite, Pierre ^a   Levy, Colin ^a   Combe, John P ^a   Scrutton, Nigel S ^a   Leys, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINE OXIDASE; BIFUNCTIONAL; DIMETHYLGLYCINE; ENZYME MECHANISM; EVOLUTIONARY ORIGIN; IN-VIVO; METHYL GROUP; MODULAR PROTEINS; REACTION CHAMBERS; REPORTER SYSTEMS; SOLVENT CAVITY; SYNTHASE; SYNTHETIC BIOLOGY; TOXIC REACTIONS;

AMINES; CELL MEMBRANES; ENZYMES; FORMALDEHYDE; HYDROCARBONS; OXIDATION; SUBSTRATES; TOXIC MATERIALS;

PLANTS (BOTANY);

DIMETHYLGLYCINE OXIDASE; FLAVOPROTEIN; FORMALDEHYDE; GREEN FLUORESCENT PROTEIN; METHYLENETETRAHYDROFOLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENE DELETION; GENETIC CONSERVATION; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PRESSURE CHAMBER; PRIORITY JOURNAL;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; DISINFECTANTS; ESCHERICHIA COLI; FORMALDEHYDE; GREEN FLUORESCENT PROTEINS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; SARCOSINE; SUBSTRATE SPECIFICITY;

EID: 67650533781     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.006262     Document Type: Article

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