Thiolate S-oxygenation controls nitric oxide (NO) photolability of a synthetic iron nitrile hydratase (Fe-NHase) model derived from mixed carboxamide/thiolate ligand

Journal of the American Chemical Society

Volumn 131, Issue 24, 2009, Pages 8340-8341

  Rose, Michael J ^a   Betterley, Nolan M ^a   Mascharak, Pradip K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; DONOR CENTERS; MODEL COMPLEXES; NITRILE HYDRATASE; SPECTROSCOPIC PARAMETERS; SYNTHETIC IRON; TETRADENTATE LIGANDS; THIOLATE;

CYANIDES; LIGANDS; NITRIC OXIDE; OXYGENATION; OXYGENATORS; SODIUM;

CHLORINE COMPOUNDS;

AMIDE; IRON; NITRIC OXIDE; NITRILE HYDRATASE; THIOPHENE; 4 (DIMETHYLAMINE)PYRIDINE; 4-(DIMETHYLAMINE)PYRIDINE; FERRIC ION; HYDROLYASE; LIGAND; PYRIDINE DERIVATIVE; THIOL DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; ENZYME ACTIVITY; OXYGENATION; PHOTOAFFINITY LABELING; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; OXIDATION REDUCTION REACTION; PHOTOCHEMISTRY; SYNTHESIS;

AMIDES; CATALYTIC DOMAIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERRIC COMPOUNDS; HYDRO-LYASES; LIGANDS; NITRIC OXIDE; OXIDATION-REDUCTION; PHOTOCHEMICAL PROCESSES; PYRIDINES; SULFHYDRYL COMPOUNDS;

EID: 67650522870     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9004656     Document Type: Article

References (14)

1. (a) Kovacs, J. Chem. Rev. 2004, 104, 825.
2. (b) Mascharak, P. K. Coord. Chem. Rev. 2002, 225, 201.
3. (c) Endo, I.; Nojiri, M.; Tsujimura, M.; Nakasako, M.; Nagashima, S.; Yohda, M.; Odaka, M. J. Inorg. Biochem. 2001, 83, 247.
4. Nagashima, S.; Nakasako, M.; Dohmae, N.; Tsujimora, M.; Takio, K.; Odaka, M.; Yohda, M.; Kamiya, N.; Endo, I. Nat. Struct. Biol. 1998, 5, 347.
5. Schweitzer, D.; Ellison, J. J.; Shoner, S. C.; Lovell, S.; Kovacs, J. A. J. Am. Chem. Soc. 1998, 120, 10996.
6. Grapperhaus, C. A.; Patra, A. K.; Mashuta, M. S. Inorg. Chem. 2002, 41, 1039.
7. Chatel, S.; Chauvin, A. S.; Tuchagues, J.-P.; Leduc, P.; Bill, E.; Chottard, J.-C.; Mansuy, D.; Artaud, I. Inorg. Chim. Acta 2002, 336, 19.
8. Harrop, T. C.; Mascharak, P. K. Inorg. Chem. 2005, 44, 6918.
9. Tyler, L. A.; Noveron, J. C.; Olmstead, M. M.; Mascharak, P. K. Inorg. Chem. 2003, 42, 5751.
10. Galardon, E.; Giorgi, M.; Artaud, I. Chem. Commun. 2004, 286.
11. Noveron, J. C.; Olmstead, M. M.; Mascharak, P. K. J. Am. Chem. Soc. 2001, 123, 3247.
12. Yano, T.; Arii, H.; Yamaguchi, S.; Funahashi, Y.; Jitsukawa, K.; Ozawa, T.; Masuda, H. Eur. J. Inorg. Chem. 2006, 3753.
13. The recent X-ray structure of Rhodococcus erythropolis AJ270 Fe-NHase revealed post-translational oxygenation of two cysteines into sulfinic acids, much like this model. See: Song, L.; Wang, M.; Shi, J.; Xue, Z.; Wang, M.-X.; Qian, S. Biochem. Biophys. Res. Commun. 2007, 362, 319.
14. Odaka, M.; Fujii, K.; Hoshino, M.; Noguchi, T.; Tsujimura, M.; Nagashima, S.; Yohda, M.; Nagamune, T.; Inoue, Y.; Endo, I. J. Am. Chem. Soc. 1997, 119, 3785.