Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design

Molecular Immunology

Volumn 46, Issue 13, 2009, Pages 2699-2705

  Halling Brown, Mark ^a   Shaban, Raheel ^a   Frampton, Dan ^b   Sansom, Clare E ^a   Davies, Matthew ^c   Flower, Darren ^c   Duffield, Melanie ^d   Titball, Richard W ^e   Brusic, Vladimir ^f   Moss, David S ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^e UNIVERSITY OF EXETER   (United Kingdom)

^f DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Immune escape; In silico vaccine design; MHC binding; Subcellular location; T cell response

Indexed keywords

ANTIGEN; BACTERIAL PROTEIN; CELL MEMBRANE PROTEIN; CYTOPLASM PROTEIN; EPITOPE; MEMBRANE PROTEIN; VACCINE;

ACCURACY; ALGORITHM; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG DESIGN; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOSURVEILLANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN LOCALIZATION; QUALITY CONTROL; T CELL DEPLETION; VACCINE PRODUCTION;

ALGORITHMS; BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; DRUG DESIGN; EPITOPES, T-LYMPHOCYTE; HLA ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; SOFTWARE; VACCINES;

BACTERIA (MICROORGANISMS);

EID: 67650494289     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.05.027     Document Type: Article

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