Altered cutaneous expression of β-defensins in dogs with atopic dermatitis

Molecular Immunology

Volumn 46, Issue 13, 2009, Pages 2449-2455

  van Damme, Catharina M M ^a   Willemse, Ton ^a,b   van Dijk, Albert ^a   Haagsman, Henk P ^a   Veldhuizen, Edwin J A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antimicrobial peptide; Atopic dermatitis; Dog; Innate immunity; Skin disease

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 103; BETA DEFENSIN 107; CALGRANULIN A; DEFENSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DOG DISEASE; DOWN REGULATION; EPIDERMIS; FEMALE; GENE EXPRESSION; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEBACEOUS GLAND; SKIN BIOPSY; UPREGULATION;

ANIMALS; BETA-DEFENSINS; DERMATITIS, ATOPIC; DOG DISEASES; DOGS; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN;

CANIS FAMILIARIS; MALASSEZIA PACHYDERMATIS; STAPHYLOCOCCUS;

EID: 67650490214     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.05.028     Document Type: Article

References (40)

1. Brinkhof B., Spee B., Rothuizen J., and Penning L.C. Development and evaluation of canine reference genes for accurate quantification of gene expression. Anal. Biochem. 356 (2006) 36-43
2. Candille S.I., Kaelin C.B., Cattanach B.M., Yu B., Thompson D.A., Nix M.A., Kerns J.A., Schmutz S.M., Millhauser G.L., and Barsh G.S. A β-defensin mutation causes black coat color in domestic dogs. Science 318 (2007) 1418-1423
3. de Jongh G.J., Zeeuwen P.L., Kucharekova M., Pfundt R., van der Valk P.G., Blokx W., Dogan A., Hiemstra P.S., van de Kerkhof P.C., and Schalkwijk J. High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J. Invest. Dermatol. 125 (2005) 1163-1173
4. Dhople V., Krukemeyer A., and Ramamoorthy A. The human β-defensin-3, an antibacterial peptide with multiple biological functions. Biochim. Biophys. Acta 1758 (2006) 1499-1512
5. Dorschner R.A., Lin K.H., Murakami M., and Gallo R.L. Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response. Pediatr. Res. 53 (2003) 566-572
6. Gambichler T., Skrygan M., Tomi N.S., Altmeyer P., and Kreuter A. Changes of antimicrobial peptide mRNA expression in atopic eczema following phototherapy. Br. J. Dermatol. 155 (2006) 1275-1278
7. Gambichler T., Skrygan M., Tomi N.S., Othlinghaus N., Brockmeyer N.H., Altmeyer P., and Kreuter A. Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin. Int. Arch. Allergy Immunol. 147 (2008) 17-24
8. Halliwell R. Revised nomenclature for veterinary allergy. Vet. Immunol. Immunopathol. 114 (2006) 207-208
9. Harder J., Bartels J., Christophers E., and Schröder J.M. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276 (2001) 5707-5713
10. Hirsch T., Jacobsen F., Steinau H.U., and Steinstraesser L. Host defense peptides and the new line of defence against multiresistant infections. Protein Pept. Lett. 15 (2008) 238-243
11. Howell M.D., Boguniewicz M., Pastore S., Novak N., Bieber T., Girolomoni G., and Leung D.Y. Mechanism of HBD-3 deficiency in atopic dermatitis. Clin. Immunol. 121 (2006) 332-338
12. Howell M.D., Novak N., Bieber T., Pastore S., Girolomoni G., Boguniewicz M., Streib J., Wong C., Gallo R.L., and Leung D.Y. Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. J. Invest. Dermatol. 125 (2005) 738-745
13. Kisich K.O., Carspecken C.W., Fiéve S., Boguniewicz M., and Leung D.Y. Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human β-defensin-3. J. Allergy Clin. Immunol. 122 (2008) 62-68
14. Kisich K.O., Howell M.D., Boguniewicz M., Heizer H.R., Watson N.U., and Leung D.Y. The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on β-defensin 3. J. Invest. Dermatol. 127 (2007) 2368-2380
15. Leung D.Y., and Bieber T. Atopic dermatitis. Lancet 361 (2003) 151-160
16. Leung D.Y., Boguniewicz M., Howell M.D., Nomura I., and Hamid Q.A. New insights into atopic dermatitis. J. Clin. Invest. 113 (2004) 651-657
17. Maeda S., Fujiwara S., Omori K., Kawano K., Kurata K., Masuda K., Ohno K., and Tsujimoto H. Lesional expression of thymus and activation-regulated chemokine in canine atopic dermatitis. Vet. Immunol. Immunopathol. 88 (2002) 79-87
18. Marsella R., Olivry T., and Maeda S. Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high-IgE beagles. Vet. Dermatol. 17 (2006) 111-120
19. Merryman-Simpson A.E., Wood S.H., Fretwell N., Jones P.G., McLaren W.M., McEwan N.A., Clements D.N., Carter S.D., Ollier W.E., and Nuttall T. Gene, (mRNA) expression in canine atopic dermatitis: microarray analysis. Vet. Dermatol. 19 (2008) 59-66
20. Nomura I., Goleva E., Howell M.D., Hamid Q.A., Ong P.Y., Hall C.F., Darst M.A., Gao B., Boguniewicz M., Travers J.B., and Leung D.Y. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J. Immunol. 171 (2003) 3262-3269
21. Nuttall T.J., Knight P.A., McAleese S.M., Lamb J.R., and Hill P.B. Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. Clin. Exp. Allergy 32 (2002) 789-795
22. Nuttall T.J., Knight P.A., McAleese S.M., Lamb J.R., and Hill P.B. T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis. Vet. Immunol. Immunopathol. 87 (2002) 379-384
23. Ong P.Y., Ohtake T., Brandt C., Strickland I., Boguniewicz M., Ganz T., Gallo R.L., and Leung D.Y. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347 (2002) 1151-1160
24. Patil A.A., Cai Y., Sang Y., Blecha F., and Zhang G. Cross-species analysis of the mammalian β-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol. Genomics 23 (2005) 5-17
25. Prélaud P., Guaguère E., and Alhaidari Z. Re-evaluation of diagnostic criteria of canine atopic dermatitis. Revue de Medicine Vétérinaire 149 (1998) 1057-1064
26. Pucheu-Haston C.M., Jackson H.A., Olivry T., Dunston S.M., and Hammerberg B. Epicutaneous sensitization with Dermatophagoides farinae induces generalized allergic dermatitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis. Clin. Exp. Allergy 38 (2008) 667-679
27. Reedy L.M., Miller W.H., and Willemse T. Allergic Skin Diseases of Dogs and Cats. 2nd ed. (1997), W.B. Saunders, London 33-44
28. Sang Y., Ortega M.T., Blecha F., Prakash O., and Melgarejo T. Molecular cloning and characterization of three β-defensins from canine testes. Infect. Immun. 73 (2005) 2611-2620
29. Sawamura D., Goto M., Shibaki A., Akiyama M., McMillan J.R., Abiko Y., and Shimizu H. β-Defensin-3 engineered epidermis shows highly protective effect for bacterial infection. Gene Ther. 12 (2005) 857-861
30. Scott D.W., Miller W.H., and Griffin C. Small Animals Dermatology (2001), W.B. Saunders, Philadelphia
31. Sinke J.D., Rutten V.P., and Willemse T. Immune dysregulation in atopic dermatitis. Vet. Immunol. Immunopathol. 87 (2002) 351-356
32. Sørensen O.E., Thapa D.R., Rosenthal A., Liu L., Roberts A.A., and Ganz T. Differential regulation of β-defensin expression in human skin by microbial stimuli. J. Immunol. 174 (2005) 4870-4879
33. Sørensen O.E., Thapa D.R., Roupe K.M., Valore E.V., Sjöbring U., Roberts A.A., Schmidtchen A., and Ganz T. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J. Clin. Invest. 116 (2006) 1878-1885
34. Sugiura H., Ebise H., Tazawa T., Tanaka K., Sugiura Y., Uehara M., Kikuchi K., and Kimura T. Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope. Br. J. Dermatol. 152 (2005) 146-149
35. Toke O. Antimicrobial peptides: new candidates in the fight against bacterial infections. Biopolymers 80 (2005) 717-735
36. Tollner T.L., Yudin A.I., Treece C.A., Overstreet J.W., and Cherr G.N. Macaque sperm release ESP13.2 and PSP94 during capacitation: the absence of ESP13.2 is linked to sperm-zona recognition and binding. Mol. Reprod. Dev. 69 (2004) 325-337
37. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., and Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 (2002) 0034. 1-0034
38. Willemse T. Atopic skin disease: a review and reconsideration of diagnostic criteria. J. Small Anim. Pract. 27 (1986) 771-778
39. Wingate K.V., Torres S.M., Silverstein K.A., Hendrickson J.A., and Rutherford M.S. Expression of endogenous antimicrobial peptides in normal canine skin. Vet. Dermatol. 20 (2009) 19-26
40. Zhou C.X., Zhang Y.L., Xiao L., Zheng M., Leung K.M., Chan M.Y., Lo P.S., Tsang L.L., Wong H.Y., Ho L.S., Chung Y.W., and Chan H.C. An epididymis-specific β-defensin is important for the initiation of sperm maturation. Nat. Cell Biol. 6 (2004) 458-464