The glucanosyltransferase Gas1 functions in transcriptional silencing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11224-11229

  Koch, Melissa R ^a   Pillus, Lorraine ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Acetylation; Beta glucan; Chromatin; S. cerevisiae; Telomeres

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; CARBOHYDRATE; GAS1 PROTEIN; GLYCOSYLTRANSFERASE; RIBOSOME DNA; SILENT INFORMATION REGULATOR PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 3; UNCLASSIFIED DRUG;

ARTICLE; BIOGENESIS; CATALYSIS; CELL NUCLEUS; CELL WALL; CHROMATIN; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME LOCALIZATION; GENE LOCUS; GENE SILENCING; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SILENCER ELEMENT; TELOMERE;

CELL WALL; CHROMATIN; DNA, RIBOSOMAL; GENE DELETION; GENE SILENCING; GENES, FUNGAL; GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE; HISTONE DEACETYLASES; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TELOMERE; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 67650485606     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900809106     Document Type: Article

References (48)

1. Rusche LN, Kirchmaier AL, Rine J (2003) The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae. Annu Rev Biochem 72:481-516.
2. Brachmann CB, et al. (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9:2888-2902.
3. Buck SW, Gallo CM, Smith JS (2004) Diversity in the Sir2 family of protein deacetylases. J Leukoc Biol 75:939-950.
4. Xu F, Zhang Q, Zhang K, Xie W, Grunstein M (2007) Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast. Mol Cell 27:890-900.
5. Yang B, Miller A, Kirchmaier AL (2008) HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin. Mol Biol Cell 19:4993-5005.
6. Yang B, Kirchmaier AL (2006) Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae. Mol Biol Cell 17:5287-5297.
7. Chou CC, Li YC, Gartenberg MR (2008) Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing. Mol Cell 31:650-659.
8. Shilatifard A (2006) Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression. Annu Rev Biochem 75:243-269.
9. Nuoffer C, Jeno P, Conzelmann A, Riezman H (1991) Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae Gas1 protein to the plasma membrane. Mol Cell Biol 11:27-37.
10. Popolo L, Vai M (1999) The Gas1 glycoprotein, a putative wall polymer cross-linker. Biochim Biophys Acta 1426:385-400.
11. Popolo L, et al. (1993) Physiological analysis of mutants indicates involvement of the Saccharomyces cerevisiae GPI-anchored protein gp115 in morphogenesis and cell separation. J Bacteriol 175:1879-1885.
12. Ragni E, et al. (2007) GAS2 and GAS4, a pair of developmentally regulated genes required for spore wall assembly in Saccharomyces cerevisiae. Eukaryot Cell 6:302-316.
13. Suter B, et al. (2004) The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae. Genetics 167:579-591.
14. Loo S, Rine J (1995) Silencing and heritable domains of gene expression. Annu Rev Cell Dev Biol 11:519-548.
15. Mitchell L, et al. (2008) Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity. Mol Cell Biol 28:2244-2256.
16. Lafon A, Chang CS, Scott EM, Jacobson SJ, Pillus L (2007) MYST opportunities for growth control: Yeast genes illuminate human cancer gene functions. Oncogene 26:5373-5384.
17. Clarke AS, Samal E, Pillus L (2006) Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell 17:1744-1757.
18. Smith JS, Boeke JD (1997) An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev 11:241-254.
19. Fritze CE, Verschueren K, Strich R, Easton Esposito R (1997) Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 16:6495-6509.
20. Renauld H, et al. (1993) Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev 7:1133-1145.
21. Mrsa V, Klebl F, Tanner W (1993) Purification and characterization of the Saccharomyces cerevisiae BGL2 gene product, a cell wall endo-beta-1,3-glucanase. J Bacteriol 175:2102-2106.
22. Lagorce A, et al. (2003) Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem 278:20345-20357.
23. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425:686-691.
24. Ho Y, et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415:180-183.
25. Garcia SN (2003) Ph.D. dissertaion (University of California at San Diego, La Jolla, CA).
26. Boxem M, et al. (2008) A protein domain-based interactome network for C. elegans early embryogenesis. Cell 134:534-545.
27. Carotti C, et al. (2004) Characterization of recombinant forms of the yeast Gas1 protein and identification of residues essential for glucanosyltransferase activity and folding. Eur J Biochem 271:3635-3645.
28. Papaleo E, Fantucci P, Vai M, De Gioia L (2006) Three-dimensional structure of the catalytic domain of the yeast beta-(1,3)-glucan transferase Gas1:Amolecular modeling investigation. J Mol Model 12:237-248.
29. Cid VJ, et al. (1995) Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol Rev 59:345-386.
30. Hampsey M (1997) A review of phenotypes in Saccharomyces cerevisiae. Yeast 13:1099-1133.
31. Meikle PJ, Bonig I, Hoogenraad NJ, Clarke AE, Stone BA (1991) The location of (1→3)-β-glucans in the walls of pollen tubes of Nicotiana alata using a (133)-β-glucan-specific monoclonal antibody. Planta 185:1-8.
32. Berger SL (2007) The complex language of chromatin regulation during transcription. Nature 447:407-412.
33. Wang X, Connelly JJ, Wang CL, Sternglanz R (2004) Importance of the Sir3 N terminus and its acetylation for yeast transcriptional silencing. Genetics 168:547-551.
34. Stone EM, Pillus L (1996) Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing. J Cell Biol 135:571-583.
35. Ray A, et al. (2003) Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan. Nat Genet 33:522-526.
36. Ai W, Bertram PG, Tsang CK, Chan TF, Zheng XF (2002) Regulation of subtelomeric silencing during stress response. Mol Cell 10:1295-1305.
37. Peng W, Togawa C, Zhang K, Kurdistani SK (2008) Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae. Genetics 179:277-289.
38. Levy-Wilson B (1983) Glycosylation, ADP-ribosylation, and methylation of Tetrahymena histones. Biochemistry 22:484-489.
39. Reeves R, Chang D, Chung SC (1981) Carbohydrate modifications of the high mobility group proteins. Proc Natl Acad Sci USA 78:6704-6708.
40. Hart GW, Housley MP, Slawson C (2007) Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature 446:1017-1022.
41. Jackson SP, Tjian R (1988) O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation. Cell 55:125-133.
42. Bouwman P, Philipsen S (2002) Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol 195:27-38.
43. Amberg DC, Burke DJ, Strathern JN (2005) Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY).
44. Darst RP, Garcia SN, Koch MR, Pillus L (2008) Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol Cell Biol 28:1361-1372.
45. Smith JS, Brachmann CB, Pillus L, Boeke JD (1998) Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 149:1205-1219.
46. James P, Halladay J, Craig EA (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:1425-1436.
47. Le S, Davis C, Konopka JB, Sternglanz R (1997) Two new S-phase-specific genes from Saccharomyces cerevisiae. Yeast 13:1029-1042.
48. Enomoto S, Berman J (1998) Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Genes Dev 12:219-232.