Modulation of rabbit sinoatrial node activation sequence by acetylcholine and isoproterenol investigated with optical mapping technique

Acta Physiologica

Volumn 196, Issue 4, 2009, Pages 385-394

  Abramochkin, D V ^a,b,c   Kuzmin, V S ^b   Sukhova, G S ^c   Rosenshtraukh, L V ^b  

^a Institute of Experimental Cardiology ^*  (Russian Federation)

^b INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Acetylcholine; Isoproterenol; Mapping; Pacemaker shift; Sinoatrial node

Indexed keywords

ACETYLCHOLINE; D 1199; DI 4 ANNEPS; DYE; ISOPRENALINE; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPICARDIUM MAPPING; NERVE STIMULATION; NONHUMAN; OPTICAL MAPPING TECHNIQUE; PACEMAKER; PARASYMPATHETIC NERVE; POSTGANGLIONIC NERVE; PRIORITY JOURNAL; RABBIT; SINUS NODE; SINUS RHYTHM;

ACETYLCHOLINE; ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; BIOLOGICAL CLOCKS; CHOLINERGIC AGENTS; ELECTRIC STIMULATION; ISOPROTERENOL; PARASYMPATHETIC NERVOUS SYSTEM; PERIODICITY; RABBITS; SINOATRIAL NODE; SYMPATHETIC NERVOUS SYSTEM; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 67650481346     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2009.01963.x     Document Type: Article

References (27)

1. Aliev, R.R., Fedorov, V.V. Rozenshtraukh, L.V. 2004. Study of the effect of acetylcholine on ion currents in single cells of true and latent pacemakers of rabbit sinus node using computer simulation. Dokl Biol Sci 397, 288 291.
2. Anderson, R.H. Ho, S.Y. 1998. The architecture of the sinus node, the atrioventricular conduction axis, and the internodal atrial myocardium. J Cardiovasc Electrophysiol 9, 1233 1248. (Pubitemid 28516153)
3. Beau, S.L., Hand, D.E., Schuessler, R.B., Bromberg, B.I., Kwon, B., Boineau, J.P. Saffitz, J.E. 1995. Relative densities of muscarinic cholinergic and β-adrenergic receptors in the canine sinoatrial node and their relation to sites of pacemaker activity. Circ Res 77, 957 963.
4. Bleeker, W.K., Mackaay, A.J., Masson-Pevet, M., Bouman, L.N. Becker, A.E. 1980. Functional and morphological organization of the rabbit sinus node. Circ Res 46, 11 22. (Pubitemid 10199433)
5. Bleeker, W.K., Mackaay, A.J., Masson-Pevet, M., Opthof, T., Jongsma, H.J. Bouman, L.N. 1982. Asymmetry of the sino-atrial conduction in the rabbit heart. J Mol Cell Cardiol 14, 633 643. (Pubitemid 13224449)
6. Boineau, J.P., Canavan, T.E., Schuessler, R.B., Cain, M.E., Corr, P.B. Cox, J.L. 1988. Demonstration of a widely distributed atrial pacemaker complex in the human heart. Circulation 77, 1221 1237. (Pubitemid 18141119)
7. Boyett, M.R., Honjo, H. Kodama, I. 2000. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res 47, 658 687. (Pubitemid 30676281)
8. Brodde, O.-E. Michel, M.C. 1999. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev 51, 651 689.
9. Dobrzynski, H., Li, J., Tellez, J., Greener, I.D., Nikolski, V.P., Wright, S.E., Parson, S.H., Jones, S.A., Lancaster, M.K., Yamamoto, H. et al. 2005. Computer three-dimensional reconstruction of the sinoatrial node. Circulation 111, 846 854. (Pubitemid 40279885)
10. Dobrzynski, H., Boyett, M.R. Anderson, R.H. 2007. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation 115, 1921 1932. (Pubitemid 46598906)
11. Fedorov, V.V., Hucker, W.J., Dobrzynski, H., Rosenshtraukh, L.V. Efimov, I.R. 2006. Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node. Am J Physiol Heart Circ Physiol 291, 612 623.
12. Hoffman, B.F. Cranefield, P. 1960. Electrophysiology of the Heart. McGraw-Hill Book Co, New York, NY.
13. James, T.N. 2002. Structure and function of the sinus node, AV node and His bundle of the human heart: part I - structure. Prog Cardiovasc Dis 45, 235 267. (Pubitemid 36142048)
14. Kodama, I., Boyett, M.R., Suzuki, R., Honjo, H. Toyama, J. 1996. Regional differences in the response of the isolated sino-atrial node of the rabbit to vagal stimulation. J Physiol 495 (Pt 3 785 801. (Pubitemid 26329122)
15. Lu, H.H. 1970. Shifts in pacemaker dominance within the sinoatrial region of cat and rabbit hearts resulting from increase of extracellular potassium. Circ Res 26, 339 346.
16. Mackaay, A.J., Bleeker, W.K., Opthof, T. Bouman, L.N. 1980a. Temperature dependence of the chronotropic action of calcium: functional inhomogeneity of the rabbit sinus node. J Mol Cell Cardiol 12, 433 443. (Pubitemid 10077865)
17. Mackaay, A.J., Opthof, T., Bleeker, W.K., Jongsma, H.J. Bouman, L.N. 1980b. Interaction of adrenaline and acetylcholine on cardiac pacemaker function. Functional inhomogeneity of the rabbit sinus node. J Pharmacol Exp Ther 214, 417 422. (Pubitemid 10049056)
18. Meek, W.J. Eyster, J. 1914. The effect of vagal stimulation and of cooling on the location of the pacemaker within the sino-auricular node. Am J Physiol 34, 368 383.
19. Opthof, T. 1988. The mammalian sinoatrial node. Cardiovasc Drugs Ther 1, 573 597. (Pubitemid 18226160)
20. Opthof, T., Duivenvoorden, J.J. Van Ginneken, A.C. 1986. Electrophysiological effects of alinidine (St 567) on sinoatrial node fibers in the rabbit heart. Cardiovasc Res 20, 727 739.
21. Roberts, I.A., Slocum, G.R. Riley, D.A. 1989. Morphological study of the innervation pattern of the rabbit sinoatrial node. Am J Anat 185, 74 88. (Pubitemid 19172088)
22. Sano, T. Yamagishi, S. 1965. Spread of excitation from the sinus node. Circ Res 16, 423 430.
23. Shibata, N., Inada, S., Mitsui, K., Honjo, H., Yamamoto, M., Niwa, R., Boyett, M.R. Kodama, I. 2001. Pacemaker shift in the rabbit sinoatrial node in response to vagal nerve stimulation. Exp Physiol 86, 177 184. (Pubitemid 32266450)
24. Tellez, J.O., Dobrzynski, H., Greener, I.D., Graham, G.M., Laing, E., Honjo, H., Hubbard, S.J., Boyett, M.R. Billeter, R. 2006. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res 99, 1384 1393. (Pubitemid 44949674)
25. Vincenzi, F.F. West, T.C. 1963. Release of autonomic mediators in cardiac tissue by direct subthreshold electrical stimulation. J Pharmacol Exp Ther 141, 185 194.
26. Vinogradova, T.M., Fedorov, V.V., Yuzyuk, T.N., Zaitsev, A.V. Rosenshtraukh, L.V. 1998. Local cholinergic suppression of pacemaker activity in the rabbit sinoatrial node. J Cardiovasc Pharmacol 32, 413 424. (Pubitemid 28399671)
27. Zhang, H., Holden, A.V., Noble, D. Boyett, M.R. 2002. Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells. J Cardiovasc Electrophysiol 13, 465 474. (Pubitemid 34494267)