Clinical implications of icaA and icaD genes in coagulase negative Staphylococci and Staphylococcus aureus bacteremia in febrile neutropenic pediatric cancer patients

Pediatric Blood and Cancer

Volumn 52, Issue 7, 2009, Pages 824-828

  El Mahallawy, Hadir A ^a   Loutfy, Samah A ^b   El Wakil, Mohamed ^c   Abd El Al, Abeer K ^d   Morcos, Hanaa ^e  

^a NATIONAL CANCER INSTITUTE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c BENI SUEF UNIVERSITY   (Egypt)

^d Al Azhar University   (Egypt)

^e NATIONAL HEPATOLOGY AND TROPICAL MEDICINE RESEARCH INSTITUTE   (Egypt)

Author keywords

Coagulase negative staphylococcal bacteremia; Febrile neutropenia; icaA and icaD genes; Slime production

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CEFEPIME; CEPHALOSPORIN; SULPERAZON; VANCOMYCIN;

ADULT; AGAR DIFFUSION; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BLOOD CULTURE; CANCER CHEMOTHERAPY; CANCER PATIENT; CHILD; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONGO; CONTROLLED STUDY; FEBRILE NEUTROPENIA; FEMALE; GENE; GENETIC ANALYSIS; HUMAN; HYPOTHESIS; ICAA GENE; ICAD GENE; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PATIENT SAFETY; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ADOLESCENT; ANTI-BACTERIAL AGENTS; BACTEREMIA; BIOFILMS; CELL ADHESION MOLECULES; CHILD; COAGULASE; CONGO RED; FEMALE; FEVER; GENES, BACTERIAL; HUMANS; MALE; NEOPLASMS; NEUTROPENIA; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 67650475372     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21964     Document Type: Article

References (19)

1. García P, Benítez R, Lam M, et al. Coagulase-negative staphylococci: Clinical, microbiological and molecular features to predict true bacteraemia. J Med Microbiol 2004;53:67-72. (Pubitemid 38352405)
2. Boyce JM. Coagulase-negative staphylococci. In: Mayhall CG, editor. Hospital epidemiology and infection control. Philadelphia, PA: LWW; 2004. pp. 495-516.
3. voEiff C, Peter G, Heilmann C. Pathogenesis of infections due to coagulase-negative staphylococci. Lancet Infect Dis 2002;2:677-685.
4. Centers for Disease Control and Prevention. Guidelines for the prevention of intravascular catheter-related infections. MMWR 2002;S1:1-32.
5. Arciola CR, Baldassarri L, Montanaro L. Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections. J Clin Microbiol 2001; 39:2151-2156. (Pubitemid 32531474)
6. O'Gara JP, Humphreys H. Staphylococcus epidermidis biofilms: Importance and implications. J Med Microbiol 2001;50:582-587. (Pubitemid 32588152)
7. Freeman DJ, Falkiner FR, Keane CT. New method for detecting slime production by coagulase negative staphylococci. J Clin Pathol 1989;42:872-874. (Pubitemid 19190761)
8. Hennig S, Nyunt Wai S, Ziebuhr W. Spontaneous switch to PIAindependent biofilm formation in an ica-positive Staphylococcus epidermidis isolate. Int J Med Microbiol 2007;297:117-122. (Pubitemid 46386493)
9. Satorres SE, Alcaraz LE. Prevalence of icaA and icaD genes in Staphylococcus aureus and Staphylococcus epidermidis strains isolated from patients and hospital staff. Cent Eur J Public Health 2007;15:87-90.
10. Ninin E, Caroff N, Espaze E, et al. Assessment of ica operon carriage and biofilm production in Staphylococcus epidermidis isolates causing bacteraemia in bone marrow transplant recipients. Clin Microbiol Infect 2006;12:446-452.
11. Persson L, Strid H, Tidefelt U, et al. Phenotypic and genotypic characterization of coagulase-negative staphylococci isolated in blood cultures from patients with haematological malignancies. Eur J Clin Microbiol Infect Dis 2006;25:299-309.
12. Chaieb K, Mahdouani K, Bakhrouf A. Detection of icaA and icaD loci by polymerase chain reaction and biofilm formation by Staphylococcus epidermidis isolated from dialysate and needles in a dialysis unit. J Hosp Infect 2005;61:225-230. (Pubitemid 41487465)
13. Arciola CR, Campoccia D, Baldassarri L, et al. Detection of biofilm formation in Staphylococcus epidermidis from implant infections. Comparison of a PCR-method that recognizes the presence of ica genes with two classic phenotypic methods. J Biomed Mater Res A 2006;76:425-430.
14. Qin Z, Yang X, Yang L, et al. Formation and properties of in vitro biofilms of ica-negative Staphylococcus epidermidis clinical isolates. J Med Microbiol 2007;56:83-93. (Pubitemid 46036280)
15. Graninger W. Serious staphylococcal infections-cyclic lipopeptides: Meeting new challenges. Clin Microbiol Infect 2008: 14:1-2. (Pubitemid 351167054)
16. Cafiso V, Bertuccio T, Santagati M, et al. Presence of the ica operon in clinical isolates of Staphylococcus epidermidis and its role in biofilm production. Clin Microbiol Infect 2004;10:1081-1088. (Pubitemid 40044981)
17. Costa SF, Barone AA, Miceli MH, et al. Colonization and molecular epidemiology of coagulase-negative staphylococcal bacteremia in cancer patients: A pilot study. Am J Infect Control 2006;34:36-40. (Pubitemid 43144354)
18. Frebourg NB, Lefebvre S, Baert S, et al. PCR-based assay for discrimination between invasive and contaminating Staphylococcus epidermidis strains. J Clin Microbiol 2000;38:877-880. (Pubitemid 30082701)
19. Greco C, Mastronardi C, Paqotto F, et al. Assessment of biofilmforming ability of coagulase-negative staphylococci from contaminated platelet preparations in Canada. Transfusion 2008; 48:969-977. (Pubitemid 351614908)