Identifying food proteins with allergenic potential: Evolution of approaches to safety assessment and research to provide additional tools

Regulatory Toxicology and Pharmacology

Volumn 54, Issue 3 SUPPL., 2009, Pages

  Ladics, Gregory S ^a   Selgrade, MaryJane K ^b  

^a DUPONT COMPANY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Food safety assessment approaches; Plant biotechnology; Protein allergenicity; Research approaches; Transgenic proteins

Indexed keywords

FOOD ALLERGEN; IMMUNOGLOBULIN E; PEPSIN A; PESTICIDE;

ALLERGENICITY; AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; CROSS REACTION; FOOD ALLERGY; FOOD ANALYSIS; FOOD CONTAMINATION; FOOD SAFETY; GENETIC ENGINEERING; GENETICALLY MODIFIED FOOD; HUMAN; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; PLANT BIOTECHNOLOGY; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; RISK ASSESSMENT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TRANSGENIC CROP;

DIETARY PROTEINS; FOOD HYPERSENSITIVITY; HUMANS; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; RISK ASSESSMENT; SAFETY;

ANIMALIA; PIPS;

EID: 67650471694     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.10.010     Document Type: Article

References (31)

1. Bannon G., Fu T.J., Kimber I., and Hinton D.M. Protein digestibility and relevance to allergenicity. Environ. Health Perspect. 111 (2003) 1122-1124
2. Bernstein J.A., Bernstein I.L., Bucchini L., Goldman L.R., Hamilton R.G., Lehrer S., Rubin C., and Sampson H.A. Clinical and laboratory investigation of allergy to genetically modified foods. Environ. Health Perspect. 111 (2003) 1114-1121
3. Bowman C.C., and Selgrade M.J.K. Differences in allergenic potential of food extracts following oral exposure in mice reflect differences in digestibility: Potential approaches to safety assessment. Toxicol. Sci. 102 1 (2008) 100-109
4. Bowman, C.C., Selgrade, M.J.K. 2008. Failure to induce oral tolerance in mice is predictive of dietary allergenic potency among foods with sensitizing capacity. Toxicol. Sci. Adv. Access doi:10.1093/toxsci/kfn200.
5. Bowman, C.C., Selgrade, M.J.K. 2008. Utility of rodent models for evaluating protein allergenicity. Same series of papers.
6. Birmingham N.P., Parvataneni S., Hassan H.M., Harkema J., Samineni S., Navuluri L., Kelly C.J., and Gangur V. An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int. Arch. Allergy Immunol. 144 (2007) 203-210
7. Braun, W., Schein, C.H., Barcia, T, Oezguen, N., Negi, S., Ivanciuc, O. 2008. Structural analysis of linear and conformational epitopes of allergens. Same series of papers.
8. Burks A.W., and Sampson H.A. Anaphylaxis and food allergy. In: Metcalfe D.D., Sampson H.A., and Simon R.A. (Eds). Food Allergy: Adverse Reactions to Foods and Food Additives (1997), Blackwell Science, Cambridge, MA 25-245
9. Chehade M., and Mayer L. Oral tolerance and its relation to food hypersensitivities. J. Allergy Clin. Immunol. 115 (2005) 3-12
10. Codex Alimentarius Commission, 2003. Alinorm 03/34: Joint FAO/WHO Food Standard Programme, Codex Alimentarius Commission, Twenty-Fifth Session, Rome, Italy, 30 June-5 July, 2003. Appendix III, Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants, and Appendix IV, Annex on the assessment of possible allergenicity. pp. 47-60.
11. FAO/WHO, 2001. Evaluation of allergenicity of genetically modified foods. Report of a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology. January 22-25, 2001. Rome, Italy.
12. Germolec D.R., Kimber I., Goldman L., and Selgrade M. Key issues for the assessment of the allergenic potential of genetically modified foods: breakout group reports. Environ. Health Perspect. 111 (2003) 1131-1139
13. Goodman R.E., Vieths S., Sampson H.A., Hill D., Ebisawa M., Taylor S.L., and van Ree R. Allergenicity assessment of genetically modified crops - what makes sense?. Nature Biotechnol. 26 (2008) 73-81
14. Herman R.A., Storer N.P., and Gao Y. Digestion assays in allergenicity assessment of transgenic proteins. Environ. Health Perspect. 114 (2006) 1154-1157
15. Hileman R.E., Silvanovich A., Goodman R.E., Rice E.A., Holleschak G., Astwood J.D., and Hefle S.L. Bioinformatic methods for allergenicity assessment using a comprehensive allergen database. Int. Arch. Allergy Immunol. 128 (2002) 280-291
16. Kimber I., Dearman R.J., Penninks A.H., Knippels L.M., Buchanan R.B., Hammerberg B., Jackson H.A., and Helm R.M. Assessment of protein allergenicity on the basis of immune reactivity: animal models. Environ. Health Perspect. 111 (2003) 1125-1130
17. Ladics G.S., Holsapple M.P., Astwood J.D., Kimber I., Knippels L.M., Helm R.M., and Dong W. Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified crops. Toxicol. Sci. 73 (2003) 8-16
18. Ladics G.S., Bardina L., Cressman R.F., Mattsson J.L., and Sampson H.A. Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p 7 protein with human sera positive for Der p 7-IgE. Regul. Toxicol. Pharmacol. 44 2 (2006) 136-143
19. Ladics G.S., Bannon G.A., Silvanovich A., and Cressman R.F. Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for the elucidation of potential identities to known allergens. Mol. Nutr. Food Res. 51 8 (2007) 985-998
20. McClain S., and Bannon G.A. Animal models of food allergy: opportunities and barriers. Curr. Allergy Asthma Rep. 6 (2006) 141-144
21. Metcalfe D.D., Astwood J.D., Townsend R., Sampson H.A., Taylor S.L., and Fuchs R.L. Assessment of the allergenic potential of foods from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr. 36 S (1996) 165-186
22. Metcalfe D.D. Introduction: what are the issues in addressing the allergenic potential of genetically modified foods?. Environ. Health Perspect. 111 (2003) 1110-1113
23. Pearson W.R., and Lipman D.J. Improved tools for biological comparison. Proc. Natl. Acad. Sci. USA 85 (1988) 2440-2448
24. Sampson H.A. Immediate reactions to foods in infants and children. In: Metcalfe D.D., Sampson H.A., and Simon R.A. (Eds). Food Allergy: Adverse Reactions to Foods and Food Additives (1997), Blackwell Science, Cambridge, MA 169-182
25. Selgrade M.K., Kimber I., Goldman L., and Germolec D.R. Assessment of allergenic potential of genetically modified foods: an agenda for future research. Environ. Health Perspect. 111 (2003) 1140-1141
26. Sicherer S.H. Determinants of systemic manifestations of food allergy. J. Allergy Clin. Immunol. 106 (2000) 251-257
27. Sicherer S.H., and Sampson H.A. Food allergy. J. Allergy Clin. Immunol. 117 2 Suppl Mini-Primer (2006) S470-S475
28. Silvanovich A., Nemeth M.A., Song P., Herman R., Tagliani L., and Bannon G.A. The value of short amino acid sequence matches for prediction of protein allergenicity. Toxicol. Sci. 90 1 (2006) 252-258
29. Stadler M.B., and Stadler B.M. Allergenicity prediction by protein sequence. FASEB J. 17 (2003) 1141-1143
30. Thomas K., Bannon G., Herouet-Guicheney C., Ladics G., Lee L., Lee S., Privalle L., Ballmer-Weber B., and Vieths S. The Utility of an international sera bank for use in evaluating the potential human allergenicity of novel proteins. Toxicol. Sci. 97 1 (2007) 27-31
31. United States General Accounting Office (GAO), 2002. Genetically modified foods: Experts view regimen of safety tests as adequate, but FDA's evaluation process could be enhanced, GAO-02-566. Washington, DC. Available from: .