Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

Molecular Immunology

Volumn 46, Issue 13, 2009, Pages 2694-2698

  Delgoffe, Greg M ^a   Kole, Thomas P ^a   Cotter, Robert J ^a   Powell, Jonathan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Anergy; Hsp90; mTOR; Rapamycin; Raptor; T cell

Indexed keywords

BINDING PROTEIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; REGULATORY ASSOCIATED PROTEIN OF TOR; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HSP90 HEAT-SHOCK PROTEINS; IMMUNOBLOTTING; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; MICE; PROTEIN BINDING; PROTEIN KINASES; PROTEOME; PROTEOMICS; SIGNAL TRANSDUCTION; SIROLIMUS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

MAMMALIA; RAPTORES;

EID: 67650457542     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.05.185     Document Type: Article

References (11)

1. Abraham R.T. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr. Opin. Immunol. 10 (1998) 330-336
2. Bishop S.C., Burlison J.A., and Blagg B.S. Hsp90: a novel target for the disruption of multiple signaling cascades. Curr. Cancer Drug Targets 7 (2007) 369-388
3. Chan S. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br. J. Cancer 91 (2004) 1420-1424
4. Colombetti S., Basso V., Mueller D.L., and Mondino A. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J. Immunol. 176 (2006) 2730-2738
5. Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., Moffat J., Brown M., Fitzgerald K.J., and Sabatini D.M. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 11 (2006) 859-871
6. Ohji G., Hidayat S., Nakashima A., Tokunaga C., Oshiro N., Yoshino K., Yokono K., Kikkawa U., and Yonezawa K. Suppression of the Mtor-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. J. Biochem. (Tokyo) 139 (2006) 129-135
7. Powell J.D., Lerner C.G., and Schwartz R.H. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 162 (1999) 2775-2784
8. Powell J.D., and Zheng Y. Dissecting the mechanism of T-cell anergy with immunophilin ligands. Curr. Opin. Investig. Drugs 7 (2006) 1002-1007
9. Sabatini D.M. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 6 (2006) 729-734
10. Schwartz R.H. T cell anergy. Annu. Rev. Immunol. 21 (2003) 305-334
11. Zheng Y., Collins S.L., Lutz M.A., Allen A.N., Kole T.P., Zarek P.E., and Powell J.D. A role for mammalian target of rapamycin in regulating t cell activation versus anergy. J. Immunol. 178 (2007) 2163-2170