Differences in immune response may explain lower survival among older men with pneumonia

Critical Care Medicine

Volumn 37, Issue 5, 2009, Pages 1655-1662

  Reade, Michael C ^a   Yende, Sachin ^a   D'Angelo, Gina ^b   Kong, Lan ^c   Kellum, John A ^a   Barnato, Amber E ^a   Milbrandt, Eric B ^a   Dooley, Christopher ^d   Mayr, Florian B ^a   Weissfeld, Lisa ^c   Angus, Derek C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d Jefferson Regional Medical Center   (United States)

Author keywords

Disparities; Inflammation mediators; Pneumonia; Quality of health care; Sepsis; Sex

Indexed keywords

ANTIBIOTIC AGENT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 9; D DIMER; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; FIBRINOLYSIS; GROUPS BY AGE; HEALTH BEHAVIOR; HEALTH CARE QUALITY; HIGH RISK BEHAVIOR; HOSPITALIZATION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INSURANCE; LIFE EXPECTANCY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PNEUMONIA; PRACTICE GUIDELINE; PRIORITY JOURNAL; RESUSCITATION; SEX DIFFERENCE; SMOKING; SURVIVAL;

AGE FACTORS; AGED; AGED, 80 AND OVER; ATTITUDE TO HEALTH; CAUSE OF DEATH; COHORT STUDIES; CRITICAL ILLNESS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITAL MORTALITY; HUMANS; IMMUNE SYSTEM PROCESSES; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PNEUMONIA; PROBABILITY; PROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SEX FACTORS; SURVIVAL ANALYSIS;

EID: 67650446189     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819da853     Document Type: Article

References (37)

1. Klein SL: The effects of hormones on sex differences in infection: From genes to behavior. Neurosci Biobehav Rev 2000; 24:627-638
2. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
3. Merrill CT, Elixhauser A: Hospitalization in the United States. Rockville, MD, Agency for Healthcare Research and Quality. 2002, HCUP Fact book no 6. AHRQ Publication No. 05-0056
4. Available at: http://www.cdc.gov/nchs. National Center for Health Statistics. Accessed February 1, 2008.
5. Schroder J, Kahlke V, Staubach KH, et al: Gender differences in human sepsis. Arch Surg 1998; 133:1200-1205
6. Raine R, Goldfrad C, Rowan K, et al: Influence of patient gender on admission to intensive care. J Epidemiol Community Health 2002; 56:418-423
7. Kaplan V, Angus DC, Griffin MF, et al: Hospitalized community-acquired pneumonia in the elderly: Age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med 2002; 65:766-772
8. Crabtree TD, Pelletier SJ, Gleason TG, et al: Gender-dependent differences in outcome after the treatment of infection in hospitalized patients. JAMA 1999; 282:2143-2148
9. Dombrovskiy VY, Martin AA, Sunderram J, et al: Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Crit Care Med 2007; 35:1244-1250
10. Eachempati SR, Hydo L, Barie PS: Gender-based differences in outcome in patients with sepsis. Arch Surg 1999; 134:1342-1347
11. Croce MA, Fabian TC, Malhotra AK, et al: Does gender difference influence outcome? J Trauma 2002; 53:889-894
12. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
13. Mokart D, Leone M, Sannini A, et al: Predictive perioperative factors for developing severe sepsis after major surgery. Br J Anaesth 2005; 95:776-781
14. Frink M, Pape HC, van Griensven M, et al: Influence of sex and age on mods and cytokines after multiple injuries. Shock 2007; 27:151-156
15. Offner PJ, Moore EE, Biffl WL: Male gender is a risk factor for major infections after surgery. Arch Surg 1999; 134:935-938
16. Rello J, Ollendorf DA, Oster G, et al: Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002; 122:2115-2121
17. O'Keefe GE, Hunt JL, Purdue GF: An evaluation of risk factors for mortality after burn trauma and the identification of gender-dependent differences in outcomes. J Am Coll Surg 2001; 192:153-160
18. Sperry JL, Minei JP: Gender dimorphism following injury: Making the connection from bench to bedside. J Leukoc Biol 2008; 83: 499-506.
19. Fine MJ, Auble TE, Yealy DM, et al: A prediction rule to identify low-risk patients with community acquired pneumonia. N Engl J Med 1997; 336:243-50
20. Charlson ME, Pompei P, Ales KL, et al: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40:373-383
21. Knaus WA, Wagner DP, Draper EA, et al: The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991; 100: 1619-1636
22. Levy MM, Fink M, Marshall JC, et al: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31:1250-1256
23. Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/ failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710
24. Available at: http://www.cms.hhs.gov/ QualityInitiativesGenInfo/15-MQMS. asp. Medicare Quality Monitoring System. Accessed February 1, 2008
25. Mandell LA, Wunderink RG, Anzueto A, et al: Infectious Diseases Society of America/ American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44 (Suppl 2):S27-S72
26. Available at: http://www.cdc.gov/nchs/ndi htm. National Death Index. Accessed February 1, 2008
27. Rich-Edwards JW, Corsano KA, Stampfer MJ: Test of the National Death Index and Equifax Nationwide Death Search. Am J Epidemiol 1994; 140:1016-1019
28. Kinasewitz GT, Yan SB, Basson B, et al: Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative microorganism. Crit Care 2004; 8:R82-R90
29. Pinsky MR, Vincent JL, Deviere J, et al: Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 1993; 3:565-575
30. Kellum JA, Kong L, Fink MP, et al: Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007; 167: 1655-1663
31. Epstein MP, Lin X, Boehnke M: A tobit variance-component method for linkage analysis of censored trait data. Am J Hum Genet 2003; 72:611-620
32. Kasal J, Jovanovic Z, Clermont G, et al: Comparison of Cox and Gray's survival models in severe sepsis. Crit Care Med 2004; 32: 700-707
33. May AK, Dossett LA, Norris PR, et al: Estra-diol is associated with mortality in critically ill trauma and surgical patients. Crit Care Med 2008; 36:62-68
34. Reade MC, Milbrandt EB, Angus DC: The impact of chronic disease on response to infection: More than just reduced physiological reserve? In: Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed). Berlin, Springer-Verlag, 2007, pp 197-207
35. Migeon BR: The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases. JAMA 2006; 295: 1428-1433
36. Arcaroli J, Silva E, Maloney JP, et al: Variant IRAK-1 haplotype is associated with increased nuclear factor-{kappa}b activation and worse outcomes in sepsis. Am J Respir Crit Care Med 2006; 173:1335-1341
37. Abe Y, Rundek T, Sciacca RR, et al: Ultrasound assessment of subclinical cardiovascular disease in a community-based multiethnic population and comparison to the Framingham score. Am J Cardiol 2006; 98: 1374-1378