Comparison of Cox and Gray's survival models in severe sepsis

Critical Care Medicine

Volumn 32, Issue 3, 2004, Pages 700-707

  Kasal, Jan ^a,c   Jovanovic, Zorana ^d   Clermont, Gilles ^a   Weissfeld, Lisa A ^b   Kaplan, Vladimir ^a,e   Watson, R Scott ^a   Angus, Derek C ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c Cumberland Medical Center   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Cox model; Gray's model; Patient outcome assessment; Proportional hazards models; Sepsis; Sepsis syndrome; Survival analysis

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; COVARIANCE; DATA ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DISEASE SIMULATION; FATALITY; FEMALE; GRAM NEGATIVE INFECTION; HAZARD ASSESSMENT; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEPSIS; SURVIVAL RATE;

ADULT; AGED; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; UNITED STATES;

EID: 1542405050     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000114819.37569.4B     Document Type: Article

References (20)

1. Brun-Buisson C, Doyon F, Carlet J, et al: Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: A multicenter prospective study in intensive care units. JAMA 1995; 274:968-974
2. Cox DR: Regression models and life tables (with discussion). J R Stat Soc Series B (Methodological) 1972; 34:187-220
3. Knaus WA, Harrell FEJ, Fisher CJ Jr, et al: The clinical evaluation of new drugs for sepsis: A prospective study design based on survival analysis. JAMA 1993; 270:1233-1241
4. Bourdais-Mannone C, Quantin C, Abrahamowicz M, et al: Testing the proportional hazards assumption in medical survival studies: Application to a population-based study of acute myeloid leukaemia. J Epidemiol Biostat 1999; 4:83-92
5. Gore SM, Pocock SJ, Kerr GR: Regression models and non-proportional hazards in the analysis of breast cancer survival. Appl Stat 1984; 33:176-195
6. Gray RJ: Flexible methods for analyzing survival data using splines, with applications to breast cancer prognosis. J Am Stat Assoc 1992; 87:942-951
7. Gray RJ: Spine-based tests in survival analysis. Biometrics 1994; 50:640-652
8. Angus DC, Birmingham MC, Balk RA, et al: E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: A randomized controlled trial. JAMA 2000; 283:1723-1730
9. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
10. Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-619
11. Grambsch PM, Therneau TM: Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81: 515-526
12. Lee ET: Statistical Methods for Survival Data Analysis. New York, John Wiley and Sons, 1992
13. Cohen J, Guyatt G, Bernard GR, et al: New strategies for clinical trials in patients with sepsis and septic shock. Crit Care Med 2001; 29:880-886
14. Angus DC, Rubenfeld GD, Roberts MS, et al: Understanding costs and cost-effectiveness in critical care: Report from the Second American Thoracic Society Workshop on Outcomes Research. Am J Respir Crit Care Med 2002; 165:540-550
15. Angus DC, Carlet J: Surviving intensive care: A report from the 2002 Brussels Roundtable. Intensive Care Med 2003; 29:368-377
16. Bates DW, Pruess KE, Lee TH: How bad are bacteremia and sepsis? Outcomes in a cohort with suspected bacteremia. Arch Intern Med 1995; 155:593-598
17. Brun-Buisson C, Doyon F, Carlet J: Bacteremia and severe sepsis in adults: A multicenter prospective survey in ICUs and wards of 24 hospitals. Am J Respir Crit Care Med 1996; 154:617-624
18. Perl TM, Dvorak L, Hwang T, et al: Long-term survival and function after suspected Gram-negative sepsis. JAMA 1995; 274: 338-345
19. Sasse KC, Nauenberg E, Long A, et al: Long-term survival after intensive care unit admission with sepsis. Crit Care Med 1995; 23: 1040-1047
20. Quartin AA, Schein RM, Kett DH, et al: Magnitude and duration of the effect of sepsis on survival. JAMA 1997; 277:1058-1063