Developmental potential of the murine embryonic stem cells transplanted into the healthy rat brain - Novel insights into tumorigenesis

Cellular Physiology and Biochemistry

Volumn 24, Issue 1-2, 2009, Pages 87-94

  Molcanyi, Marek ^a,b,e   Riess, Peter ^b   Haj Yasein, Nadia Nabil ^c   Bentz, Kristine ^d   Loehr, Mario ^a   Kuchta, Johannes ^a   Zivcak, Jozef ^e   Stenzel, Werner ^f   Miletic, Hrvoje ^g   Hescheler, Jürgen ^a   Neugebauer, Edmund ^b   Hampl, Jürgen Anton ^a   Ernestus, Ralf Ingo ^a   Schäfer, Ute ^h  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF OSLO   (Norway)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TECHNICAL UNIVERSITY OF KO ICE   (Slovakia)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g UNIVERSITY OF BERGEN   (Norway)

^h MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Embryonic stem cells (ESCs); Inflammatory Response; Tumorigenesis; Xenotransplantation

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; MACROPHAGE; MALE; MOUSE; MOUSE EMBRYO; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RAT; STEM CELL TRANSPLANTATION; XENOTRANSPLANTATION;

ANIMALIA; MURINAE; RATTUS;

EID: 67650383785     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000227816     Document Type: Article

References (28)

1. Björklund A, Lindvall O: Cell replacement therapies for central nervous system disorders. Nat Neurosci 2000;3(6):537-544.
2. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A: Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000;18(4):399-404, 2000;18(5):559.
3. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM: Embryonic stem cell lines derived from human blastocysts. Science 1998;282(5391):1145-1147, 1998;282 (5395):1827.
4. Erdö F, Bührle C, Blunk J, Hoehn M, Xia Y, Fleischmann B, Föcking M, Küstermann E, Kolossov E, Hescheler J, Hossmann KA, Trapp T: Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab 2003;23(7):780-785.
5. Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen I Y, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci 2002;99(4):2344-2349.
6. Hoehn M, Küstermann E, Blunk J, Wiedermann D, Trapp T, Wecker S, Föcking M, Arnold H, Hescheler J, Fleischmann BK, Schwindt W, Bührle C: Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci 2002;99(25):16267-16272.
7. Schouten JW, Fulp CT, Royo NC, Saatman KE, Watson DJ, Snyder EY, Trojanowski JQ, Prockop DJ, Maas AI, McIntosh TK: A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. J Neurotrauma 2004;21(11):1501-1538.
8. Molcanyi M, Riess P, Bentz K, Maegele M, Hescheler J, Schäfke B, Trapp T, Neugebauer E, Klug N, Schäfer U: Trauma-associated inflammatory response impairs embryonic stem cell survival and integration after implantation into injured rat brain. J Neurotrauma 2007;24(4):625-637.
9. Riess P, Molcanyi M, Bentz K, Maegele M, Simanski C, Carlitscheck C, Schneider A, Hescheler J, Bouillon B, Schäfer U, Neugebauer E: Embryonic stem cell transplantation after experimental traumatic brain injury dramatically improves neurological outcome, but may cause tumors. J Neurotrauma 2007;24(1):216-225, 2007;24(2):433.
10. Riess P, Bareyre FM, Saatman KE, Cheney JA, Lifshitz J, Raghupathi R, Grady MS, Neugebauer E, McIntosh TK: Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury. Restor Neurol Neurosci 2001;18(1):1-8.
11. Arnhold S, Lenartz D, Kruttwig K, Klinz FJ, Kolossov E, Hescheler J, Sturm V, Andressen C, Addicks K: Differentiation of green fluorescent protein-labeled embryonic stem cell-derived neural precursor cells into Thy-1-positive neurons and glia after transplantation into adult rat striatum. J Neurosurg 2000;93(6):1026-1032.
12. Williams RL, Hilton DJ, Pease S, Willson TA, Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola NA, Gough NM: Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988; 336(6200):684-687.
13. Miyazono M, Lee VM, Trojanowski JQ: Proliferation, cell death, and neuronal differentiation in transplanted human embryonal carcinoma (NTera2) cells depend on the graft site in nude and severe combined immunodeficient mice. Lab Invest 1995;73(2):273-283.
14. Miyazono M, Nowell PC, Finan JL, Lee VM, Trojanowski JQ: Long-term integration and neuronal differentiation of human embryonal carcinoma cells (NTera-2) transplanted into the caudoputamen of nude mice. J Comp Neurol 1996;376(4):603-613.
15. Broadwell RD, Baker BJ, Ebert P, Hickey WF, Villegas J: Intracerebral grafting of solid tissues and cell suspensions: the blood-brain barrier and host immune response. Prog Brain Res 1992;91:95-102.
16. Giulian D, Chen J, Ingeman JE, George JK, Noponen M: The role of mononu-clear phagocytes in wound healing after traumatic injury to adult mammalian brain. J Neurosci 1989;9(12):4416-4429.
17. Krum JM, Rosenstein JM: Transient coexpression of nestin, GFAP, and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds. Exp Neurol 1999;160(2):348-360.
18. Krum JM, Phillips TM, Rosenstein JM: Changes in astroglial GLT-1 expression after neural transplantation or stab wounds. Exp Neurol 2002;174(2):1371-49.
19. Persson L: Cellular reactions to small cerebral stab wounds in the rat frontal lobe. An ultrastructural study. Virchows Arch B Cell Pathol 1976;22(1):21-37.
20. Brundin P, Nilsson OG, Gage FH, Björklund A: Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons. Exp Brain Res 1985;60(1):204-208.
21. Duan WM, Brundin P, Grasbon-Frodl EM, Widner H.: Methylprednisolone prevents rejection of intrastriatal grafts of xenogeneic embryonic neural tissue in adult rats. Brain Res 1996;712(2):199-212.
22. Sakai K, Date I, Yoshimoto Y, Arisawa T, Nakashima H, Furuta T, Asari S, Ohmoto T: The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents. Brain Res 1991;565(1):167-170.
23. Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, Raghupathi R, Lenzlinger PM, Lifshitz J, Boockvar J, Neugebauer E, Snyder E Y, McIntosh TK: Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery 2002;51(4):1043-1052; Discussion 1052-1054.
24. Modo M, Stroemer R P, Tang E, Patel S, Hodges H: Effects of implantation site of stem cell grafts on behavioral recovery from stroke damage. Stroke 2002;33(9):2270-2278.
25. Johansson S, Price J, Modo M: Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/ progenitor cells. 2008 Sep;26(9):2444-2454.
26. Preynat-Seauve O, de Rham C, Tirefort D, Ferrari-Lacraz S, Krause KH, Villard J: Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells. J Cell Mol Med 2009, in press
27. Ladhoff J, Bader M, Brosel1 S, Effenberger E, Westermann D, Volk HD, Seifert M: Low immunogenicity of endothelial derivatives from rat embryonic stem cell-like cells. Cell Res. 2009;19(4):507-18.
28. Schneider A, Spitkovsky D, Riess P, Molcanyi M, Kamisetti N, Maegele M, Hescheler J, Schaefer U: "The Good into the Pot, the Bad into the Crop!'' - A New Technology to Free Stem Cells from Feeder Cells 2008;3(11):e3788.