Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia

Journal of Cellular Physiology

Volumn 220, Issue 3, 2009, Pages 632-639

  Xiong, Yali ^a   Liebermann, Dan A ^a   Tront, Jennifer S ^a   Holtzman, Eliezer J ^b   Huang, Yajue ^a   Hoffman, Barbara ^a   Geifman Holtzman, Ossie ^a,c  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c Tel Aviv University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; VASCULOTROPIN RECEPTOR 1; CELL CYCLE PROTEIN; FLT1 PROTEIN, HUMAN; GADD45A PROTEIN, HUMAN; HYPERTONIC SOLUTION; MAP2K3 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; NUCLEAR PROTEIN; PROTEIN KINASE INHIBITOR; SORBITOL;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; HYPEROSMOTIC STRESS; HYPOXIA; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STRESS; UMBILICAL VEIN; CASE CONTROL STUDY; CELL CULTURE; CELL HYPOXIA; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; OSMOTIC PRESSURE; PREGNANCY; RNA INTERFERENCE; TIME;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CELL CYCLE PROTEINS; CELL HYPOXIA; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FEMALE; HUMANS; HYPERTONIC SOLUTIONS; INTERLEUKIN-6; MAP KINASE KINASE 3; NUCLEAR PROTEINS; OSMOTIC PRESSURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; SORBITOL; TIME FACTORS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; YOUNG ADULT;

EID: 67650381916     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21800     Document Type: Article

References (26)

1. ACOG practice bulletin. 2002. Diagnosis and management of preeclampsia and eclampsia. Number 33, January2002. Obstet Gynecol 99:159-167.
2. Chelbi ST, Mondon F, Jammes H, Buffat C, Mignot TM, Tost J, Busato F, Gut I, Rebourcet R, Laissue P, Tsatsaris V, Goffinet F, Rigourd V, Carbonne B, Ferré F, Vaiman D. 2007. Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia. Hypertension 49:76-83.
3. Cudmore M, Ahmad S, Al-Ani B, Fujisawa T, Coxall H, Chudasama K, Devey LR, Wigmore SJ, Abbas A, Hewett PW, Ahmed A. 2007. Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1. Circulation 115:1789-1797.
4. Duckitt K, Harrington D. 2005. Risk factors for pre-eclampsia at antenatal booking: Systematic review of controlled studies. BMJ 330:565-571.
5. Fornace AJ, Jr., Jackman J, Hollander MC, Hoffman-Liebermann B, Liebermann DA. 1992. Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest. Ann NY Acad Sci 663:139-153.
6. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. 1994. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: A mechanism for endothelial dysfunction? Obstet Gynecol 84:937-940.
7. Gupta M, Gupta SK, Balliet AG, Hollander MC, Fornace AJ, Hoffman B, Liebermann DA. 2005. matopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxicstress-induced apoptosis. Oncogene 24:7170-7179.
8. Gupta M, Gupta SK, Hoffman B, Liebermann DA. 2006a. Gadd45a and gadd45b protect hematopoietic cells from UV induced apoptosis via distinct signaling pathways including p38 activation and JNK inhibition. J Biol Chem 281:17552-17558.
9. Gupta SK, Gupta M, Hoffman B, Liebermann DA. 2006b. Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation. Oncogene 25:5537-5546.
10. Ito M, Itakura A, Ohno Y, Nomura M, Senga T, Nagasaka T, Mizutani S. 2002. Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia. J Clin Endocrinol Metab 87:1871-1878.
11. Kirsten GF, van Zyl N, Smith M, Odendaal H. 1999. Necrotizing enterocolitis in infants born to womenwith severe early preeclampsia and absent end-diastolic umbilical artery doppler flow velocity waveforms. Am J Perinatol 16:309-314.
12. Liebermann DA, Hoffman B. 2002. Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity & inflammation. Leukemia 16:527-541.
13. Lu B, Ferrandino AF, Flavell RA. 2004. Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol 5:38-44.
14. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. 2003. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649-658.
15. Redman CW, Sargent IL. 2005. Latest advances in understanding preeclampsia. Science 308:1592-1594.
16. Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ, Jr., Ashwell JD. 2005. The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol 6:396-402.
17. Savvidou MD, Hingorani AD, Tsikas D, Frölich JC, Vallance P, Nicolaides KH. 2003. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 3:1511-1517.
18. Takacs P, Green KL, Nikaeo A, Kauma SW. 2003. Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia. Am J Obstet Gynecol 188:740-744.
19. Takekawa M, Saito H. 1998. A family of stress-inducible GADD45-like proteins mediates activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521-530.
20. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. 2006. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12:642-649.
21. Vikse BE, Irgens LM, Leivestad T, Skjaerven R, Iversen BM. 2008. Preeclampsia and the risk of end-stage renal disease. N Engl J Med 359:800-809.
22. Wallukat G, Homuth V, Fischer T, Lindschau C, Horstkamp B, Jüpner A, Baur E, Nissen E, Vetter K, Neichel D, Dudenhausen JW, Haller H, Luft FC. 1999. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest 3:945-952.
23. Yang P, Zhao Z, Reece EA. 2007. Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. Biochem Biophys Res Commun 357:749-754.
24. Zhang W, Bae I, Krishnaraju K, Azam N, Fan W, Smith K, Hoffman B, Liebermann DA. 1999. CR6: A third member in the MyD118 & Gadd 45 gene family which functions in negative growth control. Oncogene 18:4899-4907.
25. Zhou CC, Ahmad S, Mi T, Abbasi S, Xia L, Day MC, Ramin SM, Ahmed A, Kellems RE, Xia Y. 2008a. Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension 51:1010-1019.
26. Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y. 2008b. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nat Med 14:855-862.