A novel functional polymorphism, 16974 A/C, in the interleukin-12-3′ untranslated region is associated with risk of glioma

DNA and Cell Biology

Volumn 28, Issue 7, 2009, Pages 335-341

  Zhao, Bang ^a   Meng, Lan Qing ^a   Huang, Hai Neng ^a   Pan, Yun ^a   Xu, Qun Qing ^a  

^a YOUJIANG MEDICAL COLLEGE FOR NATIONALITIES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GENOMIC DNA; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 27; INTERLEUKIN 27P28; UNCLASSIFIED DRUG; INTERLEUKIN 17;

3' UNTRANSLATED REGION; ADULT; ALLELE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD LEVEL; BRAIN TUMOR; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GLIOMA; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SERUM; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR IMMUNITY; BLOOD; COMPARATIVE STUDY; GENE FREQUENCY; GENETICS; PATHOLOGY; PROGNOSIS; PROMOTER REGION; RISK FACTOR;

3' UNTRANSLATED REGIONS; ADULT; BRAIN NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; GLIOMA; HUMANS; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-17; MALE; POLYMORPHISM, GENETIC; PROGNOSIS; PROMOTER REGIONS, GENETIC; RISK FACTORS;

EID: 67650302876     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2008.0845     Document Type: Article

References (41)

1. Bethke, L., Sullivan, K., Webb, E., Murray, A., Schoemaker, M., Auvinen, A., Kiuru, A., Salminen, T., Johansen, C., Christensen, H.C., Muir, K., McKinney, P., Hepworth, S., Dimitropoulou, P., Lophatananon, A., Feychting, M., Lönn, S., Ahlbom, A., Malmer, B., Henriksson, R., Swerdlow, A., and Houlston, R. (2008). The common D302H variant of CASP8 is associated with risk of glioma. Cancer Epidemiol Biomarkers Prev 17, 987-989.
2. Brenner, A.V., Butler, M.A., Wang, S.S., Ruder, A.M., Rothman, N., Schulte, P.A., Chanock, S.J., Fine, H.A., Linet, M.S., and Inskip, P.D. (2007). Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. Carcinogenesis 28, 2543-2547.
3. Chae, S.C., Li, C.S., Kim, K.M., Yang, J.Y., Zhang, Q., Lee, Y.C., Yang, Y.S., and Chung, H.T. (2007). Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. J Hum Genet 52, 355-361.
4. Chiyo, M., Shimozato, O., Yu, L., Kawamura, K., Iizasa, T., Fujisawa, T., and Tagawa, M. (2005). Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals. Int J Cancer 115, 437-442.
5. Cordoba-Rodriguez, R., and Frucht, D.M. (2003). IL-23 and IL-27: new members of the growing family of IL-12-related cytokines with important implications for therapeutics. Expert Opin Biol Ther 3, 715-723.
6. Cozen, W., Gill, P.S., Salam, M.T., Nieters, A., Masood, R., Cockburn, M.G., Gauderman, W.J., Martínez-Maza, O., Nathwani, B.N., Pike, M.C., Van Den Berg, D.J., Hamilton, A.S., Deapen, D.M., and Mack, T.M. (2008). Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma. Blood 111, 3377-3382.
7. Del Vecchio, M., Bajetta, E., Canova, S., Lotze, M.T., Wesa, A., Parmiani, G., and Anichini, A. (2007). Interleukin-12: biological properties and clinical application. Clin Cancer Res 13, 4677-4685.
8. Emoto, Y., Yoshizawa, I., Hurwitz, R., Brinkmann, V., Kaufmann, S.H., and Emoto, M. (2008). Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes. Microbes Infect 10, 224-232.
9. Felini, M.J., Olshan, A.F., Schroeder, J.C., North, K.E., Carozza, S.E., Kelsey, K.T., Liu, M., Rice, T., Wiencke, J.K., and Wrensch, M.R. (2007). DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas. Neuroepidemiology 29, 55-58.
10. Han, S.S., Cho, E.Y., Lee, T.S., Kim, J.W., Park, N.H., Song, Y.S., Kim, J.G., Lee, H.P., and Kang, S.B. (2008). Interleukin-12 p40 gene (IL12B) polymorphisms and the risk of cervical caner in Korean women. Eur J Obstet Gynecol Reprod Biol 140, 71-75.
11. Hisada, M., Kamiya, S., Fujita, K., Belladonna, M.L., Aoki, T., Koyanagi, Y., Mizuguchi, J., Yoshimoto, T. (2004). Potent antitumor activity of interleukin-27. Cancer Res 64, 1152-1156.
12. Hölscher, C., Hölscher, A., Rü ckerl, D., Yoshimoto, T., Yoshida, H., Mak, T., Saris, C., and Ehlers, S. (2005). The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 174, 3534-3544.
13. Horinaga, M., Harsch, K.M., Fukuyama, R., Heston, W., and Larchian, W. (2005). Intravesical interleukin-12 gene therapy in an orthotopic bladder cancer model. Urology 66, 461-466.
14. Hunter, C.A. (2005). New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 5, 521-531.
15. Hussein, M.Z., Al Fikky, A., Abdel Bar, I., Attia, O. (2004). Serum IL-6 and IL-12 levels in breast cancer patients. Egypt J Immunol 11, 165-170.
16. Ichimura, K., Ohgaki, H., Kleihues, P., and Collins, V.P. (2004). Molecular pathogenesis of astrocytic tumours. J Neurooncol 70, 137-160.
17. John, S.W., Weitzner, G., Rozen, R., and Scriver, C.R. (1991). A rapid procedure for extracting genomic DNA from leukocytes. Nucleic Acids Res 19, 408.
18. Kim, C.H., Hong, M.J., Park, S.D., Kim, C.K., Park, M.Y., Sohn, H.J., Cho, H.I., Kim, T.G., and Hong, Y.K. (2006). Enhancement of anti-tumor immunity specific to murine glioma by vaccination with tumor cell lysate-pulsed dendritic cells engineered to produce interleukin-12. Cancer Immunol Immunother 55, 1309-1319.
19. Louis, D.N., Ohgaki, H., Wiestler, O.D., Cavenee, W.K., Burger, P.C., Jouvet, A., Scheithauer, B.W., and Kleihues, P. (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114, 97-109.
20. Malmer, B., Grönberg, H., Bergenheim, A.T., Lenner, P., and Henriksson, R. (1999). Familial aggregation of astrocytoma in northern Sweden: an epidemiological cohort study. Int J Cancer 81, 366-370.
21. Murakami, S., Okubo, K., Tsuji, Y., Sakata, H., Hamada, S., and Hirayama, R. (2004). Serum interleukin-12 levels in patients with gastric cancer. Surg Today 34, 1014-1019.
22. Muta, M., Matsumoto, G., Hiruma, K., Nakashima, E., and Toi, M. (2003). Study of cancer gene therapy using IL-12-secreting endothelial progenitor cells in a rat solid tumor model. Oncol Rep 10, 1765-1769.
23. Owaki, T., Asakawa, M., Morishima, N., Hata, K., Fukai, F., Matsui, M., Mizuguchi, J., and Yoshimoto, T. (2005). A role for IL-27 in early regulation of Th1 differentiation. J Immunol 175, 2191-2200.
24. Pinto, G.R., Yoshioka, F.K., Silva, R.L., Clara, C.A., Santos, M.J., Almeida, J.R., Burbano, R.R., Rey, J.A., and Casartelli, C. (2008). Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil. Genet Mol Res 7, 207-216.
25. Pytel, P. (2007). Spectrum of pediatric gliomas: implications for the development of future therapies. Expert Rev Anticancer Ther 7(12 Suppl), S51-S60.
26. Salmaggi, A., Eoli, M., Frigerio, S., Silvani, A., Gelati, M., Corsini, E., Broggi, G., and Boiardi, A. (2003). Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma. J Neurooncol 62, 297-303.
27. Shi, Y.Y., and He, L. (2005). SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15, 97-98.
28. Shimizu, M., Shimamura, M., Owaki, T., Asakawa, M., Fujita, K., Kudo, M., Iwakura, Y., Takeda, Y., Luster, A.D., Mizuguchi, J., and Yoshimoto, T. (2006). Antiangiogenic and antitumor activities of IL-27. J Immunol 176, 7317-7324.
29. Stanilova, S., and Miteva, L. (2005). Taq-I polymorphism in 3′ UTR of the IL-12B and association with IL-12p40 production from human PBMC. Genes Immunol 6, 364-366.
30. Stanilova, S., Miteva, L., and Prakova, G. (2007). Interleukin-12B-30 UTR polymorphism in association with IL-12p40 and IL-12p70 serum levels and silicosis severity. Int J Immunogenet 34, 193-199.
31. Stephens, M., Smith, M.J., and Donnelly, P. (2001). A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68, 978-989.
32. Tanriover, N., Ulu, M.O., Sanus, G.Z., Bilir, A., Canbeyli, R., Oz, B., Akar, Z., and Kuday, C. (2008). The effects of systemic and intratumoral interleukin-12 treatment in C6 rat glioma model. Neurol Res. 30, 511-517.
33. Trinchieri, G., Pflanz, S., and Kastelein, R.A. (2003). The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19, 641-644.
34. Villarino, A.V., Huang, E., and Hunter, C.A. (2004). Understanding the pro- and anti-inflammatory properties of IL-27. J Immunol 173, 715-720.
35. Weiss, J.M., Subleski, J.J., Wigginton, J.M., and Wiltrout, R.H. (2007). Immunotherapy of cancer by IL-12-based cytokine combinations. Expert Opin Biol Ther 7, 1705-1721.
36. Wiemels, J.L., Wiencke, J.K., Kelsey, K.T., Moghadassi, M., Rice, T., Urayama, K.Y., Miike, R., Wrensch, M. (2007). Allergyrelated polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev 16, 1229-1235.
37. Windsor, L., Morahan, G., Huang, D., McCann, V., Jones, T., James, I., Christiansen, F.T., and Price, P. (2004). Alleles of the IL12B 30 UTR associate with late onset of type 1 diabetes. Hum Immunol 65, 1432-1436.
38. Wrensch, M., Fisher, J.L., Schwartzbaum, J.A., Bondy, M., Berger, M., and Aldape, K.D. (2005). The molecular epidemiology of gliomas in adults. Neurosurg Focus 19, E5.
39. Yilmaz, V., Tü tü ncü, Y., Bariş Hasbal, N., Parman, Y., Serdaroglu, P., Deymeer, F., and Saruhan-Direskeneli, G. (2007). Polymorphisms of interferon-gamma, interleukin-10, and interleukin-12 genes in myasthenia gravis. Hum Immunol 68, 544-549.
40. Yilmaz, V., Yentür, S.P., and Saruhan-Direskeneli, G. (2005). IL-12 and IL-10 polymorphisms and their effects on cytokine production. Cytokine 30, 188-194.
41. You, T.G., Wang, H.S., Yang, J.H., Qian, Q.J., Fan, R.F., and Wu, M.C. (2004). Transfection of IL-2 and/or IL-12 genes into spleen in treatment of rat liver cancer. World J Gastroenterol 10, 2190-2194.