Enhancement of anti-tumor immunity specific to murine glioma by vaccination with tumor cell lysate-pulsed dendritic cells engineered to produce interleukin-12

Cancer Immunology, Immunotherapy

Volumn 55, Issue 11, 2006, Pages 1309-1319

  Kim, Chang Hyun ^a,b   Hong, Min Jung ^b   Park, Sung Dong ^b   Kim, Choong Kwon ^b   Park, Mi Young ^b   Sohn, Hyun Jung ^a,b   Cho, Hyun Il ^a,b   Kim, Tai Gyu ^a,b   Hong, Yong Kil ^a,b,c  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

Anti tumor immunity; Cytotoxic T cells; Dendritic cell; Glioma; Interleukin 12

Indexed keywords

CHROMIUM; INTERLEUKIN 12;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BIOENGINEERING; BRAIN; CANCER IMMUNOTHERAPY; CELL LYSATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GENE TRANSFER; GLIOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TUMOR IMMUNITY; VACCINATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; BRAIN NEOPLASMS; CANCER VACCINES; DENDRITIC CELLS; FEMALE; GLIOMA; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; PHENOTYPE; PROTEIN ENGINEERING; SPLEEN;

EID: 33746921924     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-006-0134-x     Document Type: Article

References (37)

1. Nazzaro JM, Neuwelt EA (1990) The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults. J Neurosurg 73:331
2. Surawicz TS, Davis F, Freels S, Laws ER Jr, Menck HR (1998) Brain tumor survival: results from the National Cancer Data Base. J Neurooncol 40:151
3. Hayes RL, Koslow M, Hiesiger EM, Hymes KB, Hochster HS, Moore EJ, Pierz DM, Chen DK, Budzilovich GN, Ransohoff J (1995) Improved long term survival after intracavitary interleukin-2 and lymphokine-activated killer cells for adults with recurrent malignant glioma. Cancer 76:840
4. Ehtesham M, Kabos P, Gutierrez MA, Samoto K, Black KL, Yu JS (2003) Intratumoral dendritic cell vaccination elicits potent tumoricidal immunity against malignant glioma in rats. J Immunother 26:107
5. Tsuboi K, Saijo K, Ishikawa E, Tsurushima H, Takano S, Morishita Y, Ohno T (2003) Effects of local injection of ex vivo expanded autologous tumor-specific T lymphocyte in cases with recurrent malignant gliomas. Clin Cancer Res 9:3294
6. Ishikawa E, Tsuboi K, Takano S, Uchimura E, Nose T, Ohno T (2004) Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model. Cancer Sci 95:98
7. Jean WC, Spellman SR, Wallenfriedman MA, Flores CT, Kurtz BP, Hall WA, Low WC (2004) Effects of combined granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2, and interleukin-12 based immunotherapy against intracranial glioma in the rat. J Neurooncol 66:39
8. Steinman R (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271
9. Satoh J, Lee YB, Kim SU (1995) T cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture. Brain Res 704:92
10. Witham TF, Erff ML, Okada H, Chambers WH, Pollack IF (2002) 7-Hydroxystaurosporine-induced apoptosis in 9L glioma cells provides an effective antigen source for dendritic cells and yields a potent vaccine strategy in an intracranial glioma model. Neurosurgery 50:1327
11. Dutta T, Spence A, Lampson LA (2003) Robust ability of IFN-gamma to upregulate class II MHC antigen expression in tumor bearing rat brains. J Neurooncol 64:31
12. Okada H, Tsugawa T, Sato H, Kuwashima N, Gambotto A, Okada K, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Chambers WH, Potter DM, Storkus WJ, Pollack IF (2004) Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines. Cancer Res 64:5830
13. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18:767
14. Cho HI, Kim HJ, Oh ST, Kim TG (2003) In vitro induction of carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocyte by dendritic cells transduced with recombinant adenoviruses. Vaccine 22:224
15. Lambert LA, Gibson GR, Maloney M, Durell B, Noelle RJ, Barth RJ Jr (2001) Intranodal immunization with tumor cell lysate-pulsed dendritic cells enhances protective antitumor immunity. Cancer Res 61:641
16. Candido KA, Shimizu K, McLaughlin JC, Kunkel R, Fuller JA, Redman BG, Thomas EK, Nickoloff BJ, Mule JJ (2001) Local administration of dendritic cells inhibits established breast tumor growth: implications for apoptosis-inducing agents. Cancer Res 61:228
17. Godelaine D, Carrasco J, Lucas S, Karanikas V, Schuler-Thurner B, Coulie PG, Schuler G, Boon T, Van Pel A (2003) Polyclonal CTL responses observed in melanoma patients vaccinated with dendritic cells pulsed with a MAGE-3.A1 peptide. J Immunol 171:4893
18. Liu BY, Chen XH, Gu QL, Li JF, Yin HR, Zhu ZG, Lin YZ (2004) Antitumor effects of vaccine consisting of dendritic cells pulsed with tumor RNA from gastric cancer. World J Gastroenterol 10:630
19. Chang AE, Redman BG, Whitfield JR, Nickoloff BJ, Braun TM, Lee PP, Geiger JD, Mule JJ (2002) A phase I trial of tumor cell lysate-pulsed dendritic cells in the treatment of advanced cancer. Clin Cancer Res 8:1021
20. Yu JS, Liu G, Ying H, Yong WH, Black KL, Wheeler CJ (2004) Vaccination with tumor cell lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res 64:4973
21. Jones VE, Mitchell MS (1996) Therapeutic vaccines for melanoma: progress and problems. Trends Biotechnol 14:349
22. Shimizu K, Thomas EK, Giedlin M, Mule JJ (2001) Enhancement of tumor cell lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein. Cancer Res 61:2618
23. Yoshida S, Morii K, Watanabe M, Saito T, Yamamoto K, Tanaka R (2001) The generation of anti-tumoral cells using dentritic cells from the peripheral blood of patients with malignant brain tumors. Cancer Immunol Immunother 50:321
24. Kurokawa T, Oelke M, Mackensen A (2001) Induction and clonal expansion of tumor-specific cytotoxic T lymphocyte from renal cell carcinoma patients after stimulation with autologous dendritic cells loaded with tumor cells. Int J Cancer 91:749
25. Yamanaka R, Abe T, Yajima N, Tsuchiya N, Homma J, Kobayashi T, Narita M, Takahashi M, Tanaka R (2003) Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial. Br J Cancer 89:1172
26. Nakahara N, Pollack IF, Storkus WJ, Wakabayashi T, Yoshida J, Okada H (2003) Effective induction of antiglioma cytotoxic T cells by coadministration of interferon-beta gene vector and dendritic cells. Cancer Gene Ther 10:549
27. Yamanaka R, Tsuchiya N, Yajima N, Honma J, Hasegawa H, Tanaka R, Ramsey J, Blaese RM, Xanthopoulos KG. (2003) Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12. J Neurosurg 99:746
28. Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh CS, Culpepper JA, Wysocka M, Trinchieri G, Murphy KM, O'Garra A (1995) Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154:5071
29. Insug O, Ku G, Ertl HC, Blaszczyk-Thurin M (2002) A dendritic cell vaccine induces protective immunity to intracranial growth of glioma. Anticancer Res 22:613
30. Saika T, Satoh T, Kusaka N, Ebara S, Mouraviev VB, Timme TL, Thompson TC (2004) Route of administration influences the antitumor effects of bone marrow-derived dendritic cells engineered to produce interleukin-12 in a metastatic mouse prostate cancer model. Cancer Gene Ther 11:317
31. Ausman JI, Shapiro WR, Rall DP. (1970) Studies on the chemotherapy of experimental brain tumors: development of an experimental model. Cancer Res 30:2394
32. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176:1693
33. Hirschowitz EA, Weaver JD, Hidalgo GE, Doherty DE (2000) Murine dendritic cells infected with adenovirus vectors show signs of activation. Gene Ther 7:1112
34. Morelli AE, Larregina AT, Ganster RW, Zahorchak AF, Plowey JM, Takayama T, Logar AJ, Robbins PD, Falo LD, Thomson AW (2000) Recombinant adenovirus induces maturation of dendritic cells via a NF-kappaB-dependent pathway. J Virol 74:9617
35. Vegh Z, Mazumder A (2003) Generation of tumor cell lysate-loaded dendritic cells preprogrammed for IL-12 production and augmented T cell response. Cancer Immunol Immunother 52:67
36. Miller G, Lahrs S, Pillarisetty VG, Shah AB, DeMatteo RP (2002) Adenovirus infection enhances dendritic cell immunostimulatory properties and induces natural killer and T-cell-mediated tumor protection. Cancer Res 62:5260
37. Zitvogel L, Mayordomo JI, Tjandrawan T, DeLeo AB, Clarke MR, Lotze MT, Storkus WJ (1996) Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J Exp Med 183:87