Structural insight into the activation mechanism of human pancreatic prophospholipase A2

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16659-16666

  Xu, Wei ^a,b   Yi, Lina ^a   Feng, Yumei ^a,e   Chen, Ling ^a,c   Liu, Jinsong ^a,c,d  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d Guangzhou International Business Incubator   (China)

^e LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; CATALYTIC CAVITIES; CATALYTIC TRIAD; MEMBRANE-BOUND; MODE OF ACTION; PHOSPHOLIPASE A2; PICHIA PASTORIS; PROPEPTIDE; SERINE PROTEASE; STRUCTURAL INSIGHTS; X-RAY STRUCTURE;

AMINO ACIDS;

CRYSTAL STRUCTURE;

PHOSPHOLIPASE A2 GROUP IB; THROMBIN; TRYPSIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME STRUCTURE; EXPRESSION VECTOR; NONHUMAN; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; THERMOSTABILITY;

AMINO ACID SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY; ENZYME ACTIVATION; GROUP IB PHOSPHOLIPASES A2; HUMANS; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PICHIA; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

PICHIA PASTORIS;

EID: 67650261015     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808029200     Document Type: Article

References (49)

1. Schaloske, R. H., and Dennis, E. A. (2006) Biochim. Biophys. Acta 1761, 1246-1259
2. Frossard, P. M., and Lestringant, G. G. (1995) Clin. Genet. 48, 284-287
3. Kuopio, T., Ekfors, T. O., Nikkanen, V., and Nevalainen, T. J. (1995) Apmis. 103, 69-78
4. Huggins, K. W., Boileau, A. C., and Hui, D. Y. (2002) Am. J. Physiol. Endocrinol. Metab. 283, E994-1001
5. Labonté E. D., Kirby, R. J., Schildmeyer, N. M., Cannon, A. M., Huggins, K. W., and Hui, D. Y. (2006) Diabetes 55, 935-941
6. Kolko, M., Prause, J. U., Bazan, N. G., and Heegaard, S. (2007) Acta Ophthalmol. Scand. 85, 317-323
7. Eskola, J. U., Nevalainen, T. J., and Aho, H. J. (1983) Clin. Chem 29, 1772-1776
8. Mayer, J. M., Rau, B., Siech, M., and Beger, H. G. (2000) Digestion 62, 164-170
9. Rae, D., Sumar, N., Beechey-Newman, N., Gudgeon, M., and Hermon-Taylor, J. (1995) Clin. Biochem. 28, 71-78
10. Schoenberg, M. H., Mayer, J. M., and Beger, H. G. (1997) Chirurg 68, 1112-1118
11. Rae, D., Beechey-Newman, N., Burditt, L., Sumar, N., and Hermon-Taylor, J. (1996) Scand. J. Gastroenterol. Suppl. 219, 24-27
12. Gudgeon, A. M., Patel, G., Hermon-Taylor, J., Hurley, P., Bowyer, R. C., and Jehanli, A. M. (1991) Ann. Clin. Biochem. 28, 497-503
13. Grataroli, R., Dijkman, R., Dutilh, C. E., van der Ouderaa, F., De Haas, G. H., and Figarella, C. (1982) Eur. J. Biochem. 122, 111-117
14. Cheng, H. Q., and Xu, G. J. (2004) Acta Biochim. Biophys. Sin. (Shanghai) 36, 583-588
15. Qin, S., Pande, A. H., Nemec, K. N., and Tatulian, S. A. (2004) J. Mol. Biol. 344, 71-89
16. Qin, S., Pande, A. H., Nemec, K. N., He, X. and Tatulian, S. A. (2005) J. Biol. Chem. 280, 36773-36783
17. Dijkstra, B. W., Drenth, J., and Kalk, K. H. (1981) Nature 289, 604-606
18. Epstein, T. M., Yu, B. Z, Pan, Y. H., Tutton, S. P., Maliwal, B. P., Jain, M. K., and Bahnson, B. J. (2001) Biochemistry 40, 11411-11422
19. Dijkstra, B. W., Drenth, J., Kalk, K. H., and Vandermaelen, P. J. (1978) J. Mol. Biol. 124, 53-60
20. Dijkstra, B. W., Kalk, K. H., Hol, W. G., and Drenth, J. (1981) J. Mol. Biol. 147, 97-123
21. Steiner, R. A., Rozeboom, H. J., de Vries, A., Kalk, K. H., Murshudov, G. N., Wilson, K. S., and Dijkstra, B. W. (2001) Acta Crystallogr. D 57, 516-526
22. Dijkstra, B. W., Renetseder, R., Kalk, K. H., Hol, W. G., and Drenth, J. (1983) J. Mol. Biol. 168, 163-179
23. Thunnissen, M. M., Franken, P. A., de Haas, G. H., Drenth, J., Kalk, K. H., Verheij, H. M., and Dijkstra, B. W. (1993) J. Mol. Biol. 232, 839-855
24. Oxford Diffraction (2008) CrysAlis, Version 1.171.32.24, Oxford Diffraction Ltd., Yarnton, UK
25. Kabsch, W. (1998) J. Appl. Crystallogr. 21, 916-924
26. CCP4 (1994) Acta Crystallogr. D 50, 760-763
27. Vagin, A., and Teplyakov, A. (1997) J. Appl. Crystallogr. 30, 1022-1025
28. Lebedev, A. A., Vagin, A. A., and Murshudov, G. N. (2008) Acta Crystallogr. D 64, 33-39
29. Langer, G., Cohen, S. X., Lamzin, V. S., and Perrakis, A. (2008) Nat, Protoc. 3, 1171-1179
30. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D 53, 240-255
31. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D 60, 2126-2132
32. Painter, J., and Merritt, E. A. (2006) Acta Crystallogr. D 62, 439-450
33. Painter, J., and Merritt, E. A. (2006) J. Appl. Crystallogr. 39, 109-111
34. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., III, Snoeyink, J., Richardson, J. S., and Richardson, D. C. (2007) Nucleic Acids Res. 35, W375-383
35. DeLano, W. L. (2002) PyMol, Version 1.Or1, Delano Scientific LLC, Palo Alto, CA
36. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D 54, 905-921
37. de Haas, G. H., Postema, N. M., Nieuwenhuizen, W., and van Deenen, L. L. (1968) Biochim. Biophys. Acta 159, 118-129
38. Fremont, D. H., Anderson, D. H., Wilson, I. A., Dennis, E. A., and Xuong, N. H. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 342-346
39. Segelke, B. W., Nguyen, D., Chee, R., Xuong, N. H., and Dennis, E. A. (1998) J. Mol. Biol. 279, 223-232
40. Krissinel, E., and Henrick, K. (2007) J. Mol. Biol. 372, 774-797
41. Bahnson, B. J. (2005) Arch Biochem. Biophys. 433, 96-106
42. Peters, A. R., Dekker, N., van den Berg, I., Boelens, R., Kaptein, R., Slotboom, A. J., and de Haas, G. H. (1992) Biochemistry 31, 10024-10030
43. Tomoo, K, Yamane, A., Ishida, T., Fujii, S., Ikeda, K., Iwama, S., Katsumura, S., Sumiya, S., Miyagawa, H., and Kitamura, K. (1997) Biochim. Biophys. Acta 1340, 178-186
44. Egmond, M. R., Hore, P. J., and Kaptein, R. (1983) Biochim. Biophys. Acta 744, 23-27
45. Pan, Y. H., Epstein, T. M., Jain, M. K., and Bahnson, B. J. (2001) Biochemistry 40, 609-617
46. Winget, J. M., Pan, Y. H., and Bahnson, B. J. (2006) Biochim. Biophys. Acta 1761, 1260-1269
47. Baker, N. A., Sept, D., Joseph, S., Hoist, M. J., and McCammon, J. A. (2001) Proc. Natl. Acad Sci. U. S. A. 98, 10037-10041
48. Wallace, A. C., Laskowski, R. A., and Thornton, J. M. (1995) Protein Eng. 8, 127-134
49. Hall, T. A. (1999) Nucleic Acids Symp. Ser. 41, 95-98