Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival time

Physiological Genomics

Volumn 38, Issue 2, 2009, Pages 158-168

  Prows, Daniel R ^a,b   Winterberg, Abby V ^b   Gibbons Jr , William J ^b   Burzynski, Benjamin B ^b   Liu, Chunyan ^b   Nick, Todd G ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Adult respiratory distress syndrome; Mouse model; Parent of origin effects; Quantitative trait locus

Indexed keywords

ACUTE LUNG INJURY; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACKCROSSING; C57BL 6 MOUSE; CHROMOSOME 1; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENETIC ANALYSIS; HYPEROXIA; MALE; MORTALITY; MOUSE; MOUSE STRAIN; NONHUMAN; PARENT; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; PROGENY; QUANTITATIVE TRAIT LOCUS; SEGREGATION ANALYSIS; SEX; SURVIVAL TIME;

ACUTE LUNG INJURY; ANALYSIS OF VARIANCE; ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; GENOTYPE; HYPEROXIA; MICE; MICE, INBRED C57BL; QUANTITATIVE TRAIT LOCI; SURVIVAL ANALYSIS;

MUS;

EID: 67650248691     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.90392.2008     Document Type: Article

References (51)

1. ARDS Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 342: 1301-1308, 2000.
2. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 2: 319-323, 1967.
3. Bassett DJ, Elbon CL, Reichenbaugh SS. Respiratory activity of lung mitochondria isolated from oxygen-exposed rats. Am J Physiol Lung Cell Mol Physiol 263: L439-L445, 1992.
4. Bhandari V, Choo-Wing R, Homer RJ, Elias JA. Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice. J Immunol 178: 4993-5000, 2007.
5. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med 12: 1286-1293, 2006.
6. Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thebaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113: 2630-2641, 2006.
7. Bosma KJ, Lewis JF. Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs 12: 461-477, 2007.
8. Broman KW, Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA. The X chromosome in quantitative trait locus mapping. Genetics 174: 2151-2158, 2006.
9. Broman KW, Wu H, Sen S, Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics 19: 889-890, 2003.
10. Carraway MS, Suliman HB, Kliment C, Welty-Wolf KE, Oury TD, Piantadosi CA. Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis. Antioxid Redox Signal 10: 269-275, 2008.
11. Chow CW, Herrera Abreu MT, Suzuki T, Downey GP. Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol 29: 427-431, 2003.
12. Crapo JD, Barry BE, Foscue HA, Shelburne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis 122: 123-143, 1980.
13. De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet 11: 150-154, 1995.
14. de Torres JP, Cote CG, Lopez MV, Casanova C, Diaz O, Marin JM, Pinto-Plata V, de Oca MM, Nekach H, Dordelly LJ, Aguirre-Jaime A, Celli BR. Gender differences in mortality in patients with COPD. Eur Respir J 33: 528-535, 2009.
15. Ferring M, Vincent JL. Is outcome from ARDS related to the severity of respiratory failure? Eur Respir J 10: 1297-1300, 1997.
16. Ganguly K, Stoeger T, Wesselkamper SC, Reinhard C, Sartor MA, Medvedovic M, Tomlinson CR, Bolle I, Mason JM, Leikauf GD, Schulz H. Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure. Physiol Genomics 31: 410-421, 2007.
17. Gharaee-Kermani M, Hatano K, Nozaki Y, Phan SH. Gender-based differences in bleomycin-induced pulmonary fibrosis. Am J Pathol 166: 1593-1606, 2005.
18. Gunther A, Walmrath D, Grimminger F, Seeger W. Pathophysiology of acute lung injury. Semin Respir Crit Care Med 22: 247-258, 2001.
19. Hager R, Cheverud JM, Wolf JB. Maternal effects as the cause of parent-of-origin effects that mimic genomic imprinting. Genetics 178: 1755-1762, 2008.
20. Jin Y, Kim HP, Chi M, Ifedigbo E, Ryter SW, Choi AM. Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1. Am J Respir Cell Mol Biol 39: 171-179, 2008.
21. Kleeberger SR, Reddy S, Zhang LY, Jedlicka AE. Genetic susceptibility to ozone-induced lung hyperpermeability: role of Toll-like receptor 4. Am J Respir Cell Mol Biol 22: 620-627, 2000.
22. Malkinson AM, Radcliffe RA, Bauer AK. Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice. Carcinogenesis 23: 411-417, 2002.
23. Matesic LE, De Maio A, Reeves RH. Mapping lipopolysaccharide response loci in mice using recombinant inbred and congenic strains. Genomics 62: 34-41, 1999.
24. Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am J Physiol Lung Cell Mol Physiol 283: L678 -L682, 2002.
25. Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 33: 319-327, 2005.
26. Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 132: 485-489, 1985.
27. Ohtsuka Y, Wang XT, Saito J, Ishida T, Munakata M. Genetic linkage analysis of pulmonary fibrotic response to silica in mice. Eur Respir J 28: 1013-1019, 2006.
28. Pagano A, Donati Y, Metrailler I, Barazzone Argiroffo C. Mitochondrial cytochrome c release is a key event in hyperoxia-induced lung injury: protection by cyclosporin A. Am J Physiol Lung Cell Mol Physiol 286: L275-L283, 2004.
29. Phua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM, Scales DC, Stather DR, Li A, Jones A, Gattas DJ, Hallett D, Tomlinson G, Stewart TE, Ferguson ND. Has mortality from acute respiratory distress syndrome decreased over time?: a systematic review. Am J Respir Crit Care Med 179: 220-227, 2009.
30. Pieczenik SR, Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83: 84-92, 2007.
31. Postma DS. Gender differences in asthma development and progression. Gend Med 4, Suppl B: S133-S146, 2007.
32. Prows DR, Hafertepen AP, Winterberg AV, Gibbons WJ Jr, Liu CY, Nick TG. Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Physiol Genomics 30: 271-281, 2007.
33. Prows DR, Hafertepen AP, Winterberg AV, Gibbons WJ Jr, Nick TG. A genetic mouse model to investigate hyperoxic acute lung injury survival. Physiol Genomics 30: 262-270, 2007.
34. Prows DR, Leikauf GD. Quantitative trait analysis of nickel-induced acute lung injury in mice. Am J Respir Cell Mol Biol 24: 740-746, 2001.
35. Ratner V, Starkov A, Matsiukevich D, Polin RA, Ten VS. Mitochondrial dysfunction contributes to alveolar developmental arrest in hyperoxia-exposed mice. Am J Respir Cell Mol Biol 40: 511-518, 2009.
36. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD. Incidence and outcomes of acute lung injury. N Engl J Med 353: 1685-1693, 2005.
37. Schapira AH. Mitochondrial disease. Lancet 368: 70-82, 2006.
38. Sidak Z. Rectangular confidence region for the means of multivariate normal distributions. J Am Stat Assoc 62: 626-633, 1967.
39. Sloane PJ, Gee MH, Gottlieb JE, Albertine KH, Peters SP, Burns JR, Machiedo G, Fish JE. A multicenter registry of patients with acute respiratory distress syndrome. Physiology and outcome. Am Rev Respir Dis 146: 419-426, 1992.
40. Suchyta MR, Clemmer TP, Elliott CG, Orme JF Jr, Weaver LK. The adult respiratory distress syndrome. A report of survival and modifying factors. Chest 101: 1074-1079, 1992.
41. Van Winkle LS, Gunderson AD, Shimizu JA, Baker GL, Brown CD. Gender differences in naphthalene metabolism and naphthalene-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 282: L1122-L1134, 2002.
42. Vancza EM, Galdanes K, Gunnison A, Hatch G, Gordon T. Age, strain, and gender as factors for increased sensitivity of the mouse lung to inhaled ozone. Toxicol Sci 107: 535-543, 2009.
43. Vincent JL, Zambon M. Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management. Clin Chest Med 27: 725-731, 2006.
44. Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. Am J Respir Cell Mol Biol 22: 535-542, 2000.
45. Ward PA. Acute lung injury: how the lung inflammatory response works. Eur Respir J Suppl 44: 22s-23s, 2003.
46. Ward PA, Mulligan MS. Molecular mechanisms in acute lung injury. Adv Pharmacol 24: 275-292, 1993.
47. Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. J Clin Invest 101: 1970-1982, 1998.
48. Wesselkamper SC, Chen LC, Gordon T. Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice. Respir Res 6: 73, 2005.
49. Westfall P, Tobias R, Rom D, Wolfinger R, Hochberg Y. Multiple Comparisons and Multiple Tests Using SAS. Cary, NC: SAS Institute, 1999.
50. Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest 133: 1120-1127, 2008.
51. Zilberberg MD, Epstein SK. Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med 157: 1159-1164, 1998.