Ovarian luteinizing hormone priming preceding follicle-stimulating hormone stimulation: Clinical and endocrine effects in women with long-term hypogonadotropic hypogonadism

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 7, 2009, Pages 2367-2373

  Balasch, Juan ^a   Fábregues, Francisco ^a   Carmona, Francisco ^a   Casamitjana, Roser ^a   Tena Sempere, Manuel ^b,c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIUM; ESTRADIOL BLOOD LEVEL; FEMALE; HORMONAL REGULATION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOPHYSIS FUNCTION; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MENSTRUAL CYCLE; OVARY FOLLICLE DEVELOPMENT; OVARY FOLLICLE MATURATION; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 67650233469     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0262     Document Type: Article

References (52)

1. Drummond AE 2006 The role of steroids in follicular growth. Reprod Biol Endocrinol 4:16
2. Walters KA, Allan CM, Handelsman DJ 2008 Androgen actions and the ovary. Biol Reprod 78:380-389
3. Smyth CD, Miro F, Howles CM, Hillier SG 1995 Effect of luteinizing hormone on follicle stimulating hormone-activated paracrine signalling in rat ovary. Hum Reprod 10:33-39
4. Hugues JN, Durnerin IC 2005 Impact of androgens on fertility: physiological, clinical and therapeutic aspects. Reprod Biomed Online 11:570-580
5. Hillier SG, Tetsuka M 1997 Role of androgens in follicle maturation and atresia. Baillieres Clin Obstet Gynaecol 11:249-560
6. Hillier SG, Tetsuka M, Fraser HM 1997 Location and developmental regulation of androgen receptor in primate ovary. Hum Reprod 12:107-111
7. Durnerin CI, Erb K, Fleming R, Hillier H, Hillier SG, Howles CM, Hugues JN, Lass A, Lyall H, Rasmussen P, Thong J, Traynor I, Westergaard L, Yates R 2008 Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation. Hum Reprod 23:421-426
8. Balasch J, Penarrubia J, Fabregues F, Vidal E, Casamitjana R, Manau D, Carmona F, Creus M, Vanrell JA 2003 Ovarian responses to recombinant FSH or HMG in normogonadotrophic women following pituitary desensitization by a depot GnRH agonist for assisted reproduction. Reprod Biomed Online 7:35-42
9. Lossl K, Andersen CY, Loft A, Freiesleben NL, Bangsboll S, Andersen AN 2008 Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial. Hum Reprod 23:1820-1829
10. Gleicher N, Barad DH 2008 Androgen priming before ovarian stimulation for IVF. Hum Reprod 23:2868-2870; author reply 2870-2871
11. Balasch J, Fabregues F 2002 Is luteinizing hormone needed for optimal ovulation induction? Curr Opin Obstet Gynecol 14:265-274
12. Shoham Z 2002 The clinical therapeutic window for luteinizing hormone in controlled ovarian stimulation. Fertil Steril 77:1170-1177
13. Filicori M 2003 Use of luteinizing hormone in the treatment of infertility: time for reassessment? Fertil Steril 79:253-255
14. Gomez R, Lima I, Simon C, Pellicer A 2004 Administration of low-dose LH induces ovulation and prevents vascular hyperpermeability and vascular endothelial growth factor expression in superovulated rats. Reproduction 127:483-489
15. The European Recombinant Human LH Study Group 1998 Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH- and FSH-deficient anovulatory women: a dose-finding study. J Clin Endocrinol Metab 83:1507-1514
16. Burgues S 2001 The effectiveness and safety of recombinant human LH to support follicular development induced by recombinant human FSH in WHO group I anovulation: evidence from a multicentre study in Spain. Hum Reprod 16:2525-2532
17. Hillier SG 2001 Gonadotropic control of ovarian follicular growth and development. Mol Cell Endocrinol 179:39-46
18. Hillier SG, De Zwart FA 1981 Evidence that granulosa cell aromatase induction/activation by follicle-stimulating hormone is an androgen receptor-regulated process in-vitro. Endocrinology 109:1303-1305
19. Harlow CR, Hillier SG, Hodges JK 1986 Androgen modulation of follicle-stimulating hormone-induced granulosa cell steroidogenesis in the primate ovary. Endocrinology 119:1403-1405
20. Vendola KA, Zhou J, Adesanya OO, Weil SJ, Bondy CA 1998 Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Invest 101:2622-2629
21. Weil S, Vendola K, Zhou J, Bondy CA 1999 Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development. J Clin Endocrinol Metab 84:2951-2956
22. Weil SJ, Vendola K, Zhou J, Adesanya OO, Wang J, Okafor J, Bondy CA 1998 Androgen receptor gene expression in the primate ovary: cellular localization, regulation, and functional correlations. J Clin Endocrinol Metab 83:2479-2485
23. Vendola K, Zhou J, Wang J, Famuyiwa OA, Bievre M, Bondy CA 1999 Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary. Biol Reprod 61:353-357
24. Balasch J, Fabregues F, Penarrubia J, Carmona F, Casamitjana R, Creus M, Manau D, Casals G, Vanrell JA 2006 Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH. Hum Reprod 21:1884-1893
25. Barad D, Gleicher N 2006 Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod 21:2845-2849
26. Massin N, Cedrin-Durnerin I, Coussieu C, Galey-Fontaine J, Wolf JP, Hugues JN 2006 Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique: a prospective, randomized, double-blind study. Hum Reprod 21:1204-1211
27. Fabregues F, Penarrubia J, Creus M, Manau D, Casals G, Carmona F, Balasch J 2009 Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial. Hum Reprod 24:349-359
28. Shoham Z, Smith H, Yeko T, O'Brien F, Hemsey G, O'Dea L 2008 Recombinant LH (lutropin alfa) for the treatment of hypogonadotrophic women with profound LH deficiency: a randomized, double-blind, placebo-controlled, proof-of-efficacy study. Clin Endocrinol (Oxf) 69:471-478
29. Couzinet B, Lestrat N, Brailly S, Forest M, Schaison G 1988 Stimulation of ovarian follicular maturation with pure follicle-stimulating hormone in women with gonadotropin deficiency. J Clin Endocrinol Metab 66:552-556
30. Shoham Z, Balen A, Patel A, Jacobs HS 1991 Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients. Fertil Steril 56:1048-1053
31. Balasch J, Miro F, Burzaco I, Casamitjana R, Civico S, Ballesca JL, Puerto B, Vanrell JA 1995 The role of luteinizing hormone in human follicle development and oocyte fertility: evidence from in-vitro fertilization in a woman with long-standing hypogonadotrophic hypogonadism and using recombinant human follicle stimulating hormone. Hum Reprod 10:1678-1683
32. Daya S 1999 Differences between crossover and parallel study designs: debate? Fertil Steril 71:771-773
33. Balasch J, Fábregeues F 2003 Pregnancy after administration of high-dose recombinant human LH alone to support final stages of follicular maturation in a woman with long-standing hypogonadotrophic hypogonadism. Reprod Biomed Online 6:427-431
34. le Cotonnec JY, Porchet HC, Beltrami V, Munafo A 1998 Clinical pharmacology of recombinant human luteinizing hormone. I. Pharmacokinetics after intravenous administration to healthy female volunteers and comparison with urinary human luteinizing hormone. Fertil Steril 69:189-194
35. Porchet HC, Le Cotonnec JY, Neuteboom B, Canali S, Zanolo G 1995 Pharmacokinetics of recombinant human luteinizing hormone after intravenous, intramuscular, and subcutaneous administration in monkeys and comparison with intravenous administration of pituitary human luteinizing hormone. J Clin Endocrinol Metab 80:667-673
36. The European Recombinant LH Study Group 2001 Human recombinant luteinizing hormone is as effective as, but safer than, urinary human chorionic gonadotropin in inducing final follicular maturation and ovulation in in vitro fertilization procedures: results of a multicenter double-blind study. J Clin Endocrinol Metab 86:2607-2618
37. Manau D, Fabregues F, Arroyo V, Jimenez W, Vanrell JA, Balasch J 2002 Hemodynamic changes induced by urinary human chorionic gonadotropin and recombinant luteinizing hormone used for inducing final follicular maturation and luteinization. Fertil Steril 78:1261-1267
38. Peinado JA, Molina I, Pla M, Tresguerres JA, Romeu A 1995 Recombinant-human luteinizing hormone (r-hLH) as ovulatory stimulus in superovulated does. J Assist Reprod Genet 12:61-64
39. Welt CK 2001 The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. Curr Opin Obstet Gynecol 14:317-323
40. de Kretser DM, Hedger MP, Loveland KL, Phillips DJ 2002 Inhibins, activins and follistatin in reproduction Human Reprod Update 8:529-541
41. Gordon A, Garrido-Gracia JC, Aguilar R, Bellido C, Velasco JA, Millan Y, Tena-Sempere M, Martin de Las Mulas J, Sanchez-Criado JE 2008 The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expression. J Endocrinol 196:583-592
42. Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SR 2005 Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab 90:6609-6615
43. Dhillo WS, Chaudhri OB, Thompson EL, Murphy KG, Patterson M, Ramachandran R, Nijher GK, Amber V, Kokkinos A, Donaldson M, Ghatei MA, Bloom SR 2007 Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. J Clin Endocrinol Metab 92:3958-3966
44. Roa J, Tena-Sempere M 2007 KiSS-1 system and reproduction: comparative aspects and roles in the control of female gonadotropic axis in mammals. Gen Comp Endocrinol 153:132-140
45. Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2008 New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol 29:48-69
46. Castellano JM, Gaytan M, Roa J, Vigo E, Navarro VM, Bellido C, Dieguez C, Aguilar E, Sanchez-Criado JE, Pellicer A, Pinilla L, Gaytan F, Tena-Sempere M 2006 Expression of KiSS-1 in rat ovary: putative local regulator of ovulation? Endocrinology 147:4852-4862
47. Gaytan F, Gaytan M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sanchez-Criado JE, Millar RP, Pellicer A, Fraser H, Tena-Sempere M 2009 KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset, and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction. Am J Physiol Endocrinol Metab 296:E520-E531
48. Moore Jr WT, Ward DN 1980 Pregnant mare serum gonadotropin. An in vitro biological characterization of the lutropin-follitropin dual activity. J Biol Chem 255:6930-6936
49. Navarro VM, Castellano JM, Fernandez-Fernandez R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2005 Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology 146:156-163
50. Navarro VM, Castellano JM, Fernandez-Fernandez R, Tovar S, Roa J, Mayen A, Barreiro ML, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2005 Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology 146:1689-1697
51. Gutierrez-Pascual E, Martinez-Fuentes AJ, Pinilla L, Tena-Sempere M, Malagon MM, Castano JP 2007 Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. J Neuroendocrinol 19:521-530
52. Roseweir AK, Millar RP 2009 The role of kisspeptin in the control of gonadotrophin secretion. Human Reprod Update 15:203-212