The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction

Current Opinion in Obstetrics and Gynecology

Volumn 14, Issue 3, 2002, Pages 317-323

  Welt, Corrine K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; FOLLISTATIN; INHIBIN;

FEMALE; HORMONAL REGULATION; HORMONE ACTION; HUMAN; INFERTILITY; INFERTILITY THERAPY; OVARY CANCER; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; REPRODUCTION; REVIEW;

ACTIVINS; FEMALE; FERTILITY; FOLLISTATIN; HUMANS; INFERTILITY, FEMALE; INHIBINS; POLYCYSTIC OVARY SYNDROME; PREGNANCY;

EID: 0036266165     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001703-200206000-00012     Document Type: Review

References (74)

1. Chemical and biological characterization of the inhibin family of protein hormones
2. Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis
3. Regulatory functions for inhibin and activin in human ovaries
4. Activin receptors and cellular signaling by the receptor serine kinase family
5. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
6. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism
7. Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation
8. Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells
9. Expression cloning of an activin receptor, a predicted transmembrane serine kinase
10. Identification of high affinity binding sites for inhibin on ovine pituitary cells in culture
11. Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice
12. Structure and expression of a membrane component of the inhibin receptor system
13. Modulation of activin signal transduction by inhibin B and inhibin-binding protein (InhBP)
14. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
15. Antagonism of activin by inhibin and inhibin receptors: A functional role for betaglycan
16. Recombinant human inhibin-A administered early in the menstrual cycle alters concurrent pituitary and follicular, plus subsequent luteal, function in rhesus monkeys
17. Systemic and intraluteal infusion of inhibin A or activin A in rhesus monkeys during the luteal phase of the menstrual cycle
18. Main inhibitor of follicle stimulating hormone in the luteal-follicular transition: Inhibin A, oestradiol, or inhibin B?
19. Reproductive deficiencies in transgenic mice expressing the rat inhibin alpha-subunit gene
20. Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit
21. Synergism between FSH and activin in the regulation of proliferating cell nuclear antigen (PCNA) and cyclin D2 expression in rat granulosa cells
22. Activin stimulates proliferation of rat ovarian thecal-interstitial cells
23. Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions
24. Differential regulation of inhibin B and inhibin A by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles
25. Dynamic changes in the intrafollicular inhibin/activin/follistatin axis during human follicular development: Relationship to circulating hormone concentrations
26. Inhibin A, inhibin B and activin A in the follicular fluid of regularly cycling women
27. Frequency modulation of follicle-stimulating hormone (FSH) during the luteal-follicular transition: Evidence for FSH control of inhibin B in normal women
28. Differential regulation of inhibin A and inhibin B by luteinizing hormone, follicle-stimulating hormone, and stage of follicle development
29. Circulating inhibins and activin A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in-vitro fertilization-embryo transfer
30. Both inhibin A and B respond to exogenous follicle-stimulating hormone in the follicular phase of the human menstrual cycle
31. Inhibin A and inhibin B responses to gonadotropin withdrawal depends on stage of follicle development
32. Inhibin A and inhibin B reflect ovarian function in assisted reproduction but are less useful at predicting outcome
33. Structure of the rat inhibin and activin beta-A-subunit gene and regulation in an ovarian granulosa cell line
34. Regulation of the alpha-inhibin gene by cyclic adenosine 3′5′-monophosphate after transfection into rat granulosa cells
35. Analysis of the 5′-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms
36. Two messenger ribonucleic acids encoding the common βB-chain of inhibin and activin have distinct 5′-initiation sites and are differentially regulated in rat granulosa cells
37. Transforming growth factor-β1 and -β2 induce inhibin and activin βB subunit messenger ribonucleic acid levels in cultured human granulosa-luteal cells
38. Regulation of inhibin/activin subunit messenger ribonucleic acids (mRNAs) by activin A and expression of activin receptor mRNAs in cultured human granulosa-luteal cells
39. Regulation of immunoreactive inhibin A and B secretion in cultured human granulosa-luteal cells by gonadotropins, activin A and insulin-like growth factor type-1 receptor
40. Dimeric inhibin A and B production are differentially regulated by hormones and local factors in rat granulosa cells
41. Activation of bone morphogenetic protein signaling pathway induces inhibin β B-subunit messenger ribonucleic acid and secreted inhibin B levels in cultured human granulosa-luteal cells
42. Serum alpha-inhibin levels in polycystic ovary syndrome: Relationship to the serum androstenedione level
43. Serum levels of inhibins are differentially altered in patients with polycystic ovary syndrome: Effects of being overweight and relevance to hyperandrogenism
44. Inhibin A and inhibin B in women with polycystic ovarian syndrome during treatment with FSH to induce monoovulation
45. Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy: A possible mechanism regulating emergence of the dominant follicle
46. Absent biologically relevant associations between serum inhibin B concentrations and characteristics of polycystic ovary syndrome in normogonadotrophic anovulatory infertility
47. Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome
48. Relatively Iow levels of dimeric inhibin circulate in men and women with polycystic ovarian syndrome using a specific two-site enzyme-linked immunosorbent assay
49. The rise of estradiol and inhibin B after acute stimulation with follicle-stimulating hormone predict the follicle cohort size in women with polycystic ovary syndrome, regularly menstruating women with polycystic ovaries, and regularly menstruating women with normal ovaries
50. Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles
51. Intrafollicular inhibin/activin/follistatin in maturing human follicles across the normal menstrual cycle: Comparison to PCOS follicles
52. Activin-binding protein from rat ovary is follistatin
53. Activin-binding protein is present in pituitary
54. Isolation and partial characterization of follistatin: A single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone
55. The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin
56. An update on the roles of inhibin, activin, and follistatin as local regulators of folliculogenesis
57. Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is with follistatin
58. Allelic variants of the follistatin gene in polycystic ovary syndrome
59. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome
60. Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome
61. Inhibin-B as a test of ovarian reserve for infertile women
62. Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF
63. Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle
64. Inhibin-B: The physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening
65. Day 5 inhibin B serum concentrations as predictors of assisted reproductive technology outcome in cycles stimulated with gonadotrophin-releasing hormone agonist-gonadotrophin treatment
66. Relationship between serum inhibin A and B and ovarian follicle development after a dally fixed dose administration of recombinant follicle-stimulating hormone
67. Secretion of inhibin B during ovarian stimulation is decreased in infertile women with endometriosis
68. The inhibins and ovarian cancer
69. Inhibin forms in serum from postmenopausal women with ovarian cancers
70. Combined inhibin and CA125 assays in the detection of ovarian cancer
71. Serum inhibin and disease status in women with ovarian granulosa cell tumors
72. A prospective study of inhibin in granulosa cell tumors of the ovary
73. Inhibin as a marker for granulosa-cell tumors
74. Identification of specific inhibin A-binding proteins on mouse Leydig (TM3) and sertoli (TM4) cell lines