Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre

Journal of Gastrointestinal and Liver Diseases

Volumn 17, Issue 2, 2008, Pages 135-139

  Krawczyk, Marcin ^a,b   Wolska, Malgorzata ^a,b   Schwartz, Stephanie ^b   Gruenhage, Frank ^b,c   Terjung, Birgit ^b   Portincasa, Piero ^d   Sauerbruch, Tilman ^b   Lammert, Frank ^b,c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

Breath test; Lactase; Lactose intolerance; Single nucleotide polymorphism

Indexed keywords

LACTASE;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; BASE PAIRING; BLOATING; BREATH ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DIARRHEA; FEMALE; GENETIC ANALYSIS; GENOTYPE; HUMAN; HYDROGEN BREATH TEST; LACTASE DEFICIENCY; LACTOSE INTOLERANCE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREDICTION; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; TERTIARY HEALTH CARE; UNIVERSITY HOSPITAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AIR; BREATH TESTS; DNA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDROGEN; LACTASE; LACTOSE INTOLERANCE; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES;

EID: 46449122801     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Auricchio S, Rubino A, Landolt M, Semenza G, Prader A. Isolated Intestinal lactase deficiency in the adult. Lancet 1963; 2: 324-326.
2. Terjung B, Lammert F. Laktoseintoleranz: Neue Aspekte eines altcn Problems. Dtsch Med Wochenschr 2007; 132: 271-275.
3. Saavedra JM, Perman JA. Current concepts in lactose malabsorption and intolerance. Annu Rev Nutr 1989; 9: 475-502.
4. Scrimshaw NS, Murray EB. The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr 1988; 48(4 Suppl): 1079-1159.
5. Vesa TH, Korpela RA, Sahi T. Tolerance to small amounts of lactose in lactose maldigesters. Am J Clin Nutr 1996; 64: 197-201.
6. Savaiano DA, Boushey CJ, McCabe GP. Lactose intolerance symptoms assessed by meta-analysis: a grain of truth that leads to exaggeration. J Nutr 2006; 136: 1107-1113.
7. Lember M, Torniainen S, Kull M, et al. Lactase non-persistence and milk consumption in Estonia. World J Gastroenterol 2006; 12: 7329-7331.
8. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002; 30: 233-237.
9. Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Jarvela I. Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 2003; 52: 647-652.
10. Ridefelt P, Hakansson LD. Lactose intolerance: lactose tolerance test versus genotyping. Scand J Gastroenterol 2005; 40: 822-826.
11. Nilsson TK, Olsson LA. Simulataneous genotyping of three lactose tolerance-linked polymorphisms LCT-13907C>G,LCT-13910C>T and LCT-13915T>G with Pyrosequencing technology. Clin Chem Lab Med 2008; 46: 80-84.
12. Calloway DH, Murphy EL, Bauer D. Determination of lactose intolerance by breath analysis. Am J Dig Dis 1969; 14: 811-815.
13. Metz G, Jenkins DJ, Peters TJ, Newman A, Blendis LM. Breath hydrogen as a diagnostic method for hypolactasia. Lancet 1975; 1: 1155-1157.
14. Von Tirpitz C, Kohn C, Steinkamp M, et al. Lactose intolerance in active Crohn s disease: clinical value of duodenal lactase analysis. J Clin Gastroenterol 2002; 34: 49-53.
15. Pimentel M, Kong Y, Park S. Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption. Am J Gastroenterol 2003; 98: 2700-2704.
16. Rosenthal A, Solomons NW. Time-course of cigarette smoke contamination of clinical hydrogen breath-analysis tests. Clin Chem 1983; 29: 1980-1981.
17. Troelsen JT, Olsen J, Moller J, Sjostrom H. An upstream polymorphism associated with lactase persistence has increased enhancer activity. Gastroenterology 2003; 125: 1686-1694.
18. Büning C, Genschel J, Jurga J, et al. Introducing genetic testing for adult-type hypolactasia. Digestion 2005; 71: 245-250.
19. Kerber M, Oberkanins C, Kriegshäuser G, et al. Hydrogen breath testing versus LCT genotyping for the diagnosis of lactose intolerance: a matter of age? Clin Chim Acta 2007; 383: 91-96.
20. Bodlaj G, Stöcher M, Hufnagl P, et al. Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance. Clin Chem 2006; 52: 148-151.
21. Obermayer-Pietsch BM, Gugatschka M, Reitter S, et al. Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption? Osteoporos Int 2007; 18: 445-451.