Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 7, 2009, Pages 2226-2231

  Lawson, Elizabeth A ^a   Zhang, Xun ^a   Crocker, Jonathan T ^b   Wang, Wei Lien ^c   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ADULT; CASE REPORT; CONFERENCE PAPER; CONTROLLED STUDY; GENE; GENE LOCUS; GENOME IMPRINTING; HEMANGIOPERICYTOMA; HUMAN; HUMAN TISSUE; HYPOGLYCEMIA; IGF2 GENE; IMMUNOHISTOCHEMISTRY; LIVER TUMOR; MALE; METASTASIS; METHYLATION; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

EID: 67650221412     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0153     Document Type: Conference Paper

References (39)

1. Fukuda I, Hizuka N, Ishikawa Y, Yasumoto K, Murakami Y, Sata A, Morita J, Kurimoto M, Okubo Y, Takano K 2006 Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia. Growth Horm IGF Res 16:211-216
2. Almeida MQ, Fragoso MC, Lotfi CF, Santos MG, Nishi MY, Costa MH, Lerario AM, Maciel CC, Mattos GE, Jorge AA, Mendonca BB, Latronico AC 2008 Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors. J Clin Endocrinol Metab 93:3524-3531
3. Reeve AE, Eccles MR, Wilkins RJ, Bell GI, Millow LJ 1985 Expression of insulin-like growth factor-II transcripts in Wilms' tumour. Nature 317:258-260
4. Haselbacher GK, Irminger JC, Zapf J, Ziegler WH, Humbel RE 1987 Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level. Proc Natl Acad Sci USA 84:1104-1106
5. Gicquel C, Bertagna X, Schneid H, Francillard-Leblond M, Luton JP, Girard F, Le Bouc Y 1994 Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors. J Clin Endocrinol Metab 78:1444-1453
6. Lambert S, Vivario J, Boniver J, Gol-Winkler R 1990 Abnormal expression and structural modification of the insulin-like growth-factor-II gene in human colorectal tumors. Int J Cancer 46:405-410
7. Murphy SK, Huang Z, Wen Y, Spillman MA, Whitaker RS, Simel LR, Nichols TD, Marks JR, Berchuck A 2006 Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. Mol Cancer Res 4:283-292
8. Cariani E, Seurin D, Lasserre C, Franco D, Binoux M, Brechot C 1990 Expression of insulin-like growth factor II (IGF-II) in human primary liver cancer: mRNA and protein analysis. J Hepatol 11:226-231
9. Yoshimizu T, Miroglio A, Ripoche MA, Gabory A, Vernucci M, Riccio A, Colnot S, Godard C, Terris B, Jammes H, Dandolo L 2008 The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci USA 105:12417-12422
10. Ogawa O, Eccles MR, Szeto J, McNoe LA, Yun K, Maw MA, Smith PJ, Reeve AE1993 Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature 362:749-751
11. Fu VX, Dobosy JR, Desotelle JA, Almassi N, Ewald JA, Srinivasan R, Berres M, Svaren J, Weindruch R, Jarrard DF 2008 Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate. Cancer Res 68:6797-6802
12. Ohta M, Sugimoto T, Seto M, Mohri D, Asaoka Y, Tada M, Tanaka Y, Yamaji Y, Kanai F, Kawabe T, Omata M 2008 Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II. Hum Pathol 39:1301-1308
13. Chen CL, Ip SM, Cheng D, Wong LC, Ngan HY 2000 Loss of imprinting of the IGF-II and H19 genes in epithelial ovarian cancer. Clin Cancer Res 6:474-479
14. Oda H, Kume H, Shimizu Y, Inoue T, Ishikawa T 1998 Loss of imprinting of igf2 in renal-cell carcinomas. Int J Cancer 75:343-346
15. Anderson J, Gordon A, McManus A, Shipley J, Pritchard-Jones K 1999 Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma. Neoplasia 1:340-348
16. Bertherat J, Logié A, Gicquel C, Mourriéras F, Luton JP, Le Bouc Y 2000 Alterations of the 11p15 imprinted region and the IGFs system in a case of recurrent non-islet-cell tumour hypoglycaemia (NICTH). Clin Endocrinol (Oxf) 53:213-220
17. Hodzic D, Delacroix L, Willemsen P, Bensbaho K, Collette J, Broux R, Lefèbvre P, Legros JJ, Grooteclaes M, Winkler R 1997 Characterization of the IGF system and analysis of the possible molecular mechanisms leading to IGF-II overexpression in a mesothelioma. Horm Metab Res 29:549-555
18. Zhang X, Zhou Y, Mehta KR, Danila DC, Scolavino S, Johnson SR, Klibanski A 2003 A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab 88:5119-5126
19. Ulaner GA, Vu TH, Li T, Hu JF, Yao XM, Yang Y, Gorlick R, Meyers P, Healey J, Ladanyi M, Hoffman AR 2003 Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. Hum Mol Genet 12:535-549
20. Daughaday WH, Emanuele MA, Brooks MH, Barbato AL, Kapadia M, Rotwein P 1988 Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 319:1434-1440
21. Ron D, Powers AC, Pandian MR, Godine JE, Axelrod L 1989 Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumor-induced hypoglycemia. J Clin Endocrinol Metab 68:701-706
22. Holt RI, Teale JD, Jones JS, Quin JD, McGregor AM, Miell JP 1998 Gene expression and serum levels of insulin-like growth factors (IGFs) and IGF-binding proteins in a case of non-islet cell tumour hypoglycaemia. Growth Horm IGF Res 8:447-454
23. Chung J, Henry RR 1996 Mechanisms of tumor-induced hypoglycemia with intraabdominal hemangiopericytoma. J Clin Endocrinol Metab 81:919-925
24. Mayou SC, Benn JJ, Sonksen PH, Black MM 1989 Paraneoplastic rhinophyma and the Leser-Trelat sign. Clin Exp Dermatol 14:253-255
25. Stein RH, Herman SD, Phelps RG, Sapadin AN 2004 Florid eruption of seborrheic keratoses associated with elevated insulin-like growth factor, hypoglycemia, and solitary fibrous tumor of the pleura. Int J Dermatol 43:944-947
26. Herr HW, Hennessy WT, Kantor A 1990 Pelvic sarcoma causing gynecomastia. J Urol 143:1008-1009
27. Derakhshani P, Neubauer S, Braun M, Heidenreich A, Engelmann U 1999 Giant retroperitoneal hemangiopericytoma with paraneoplastic gynecomastia. Case report and literature review. Urol Int 62:223-225
28. d'Arville CN, Nouri-Aria KT, Johnson P, Williams R 1991 Regulation of insulin-like growth factor II gene expression by hepatitis B virus in hepatocellular carcinoma. Hepatology 13:310-315
29. Moulton T, Crenshaw T, Hao Y, Moosikasuwan J, Lin N, Dembitzer F, Hensle T, Weiss L, McMorrow L, Loew T, Kraus W, Gerald W, Tycko B 1994 Epigenetic lesions at the H19 locus in Wilms' tumour patients. Nat Genet 7:440-447
30. Taniguchi T, Sullivan MJ, Ogawa O, Reeve AE 1995 Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor. Proc Natl Acad Sci USA 92:2159-2163
31. Jelinic P, Shaw P 2007 Loss of imprinting and cancer. J Pathol 211:261-268
32. Eriksson T, Frisk T, Gray SG, von Schweinitz D, Pietsch T, Larsson C, Sandstedt B, Ekström TJ 2001 Methylation changes in the human IGF2 p3 promoter parallel IGF2 expression in the primary tumor, established cell line, and xenograft of a human hepatoblastoma. Exp Cell Res 270:88-95
33. Li X, Adam G, Cui H, Sandstedt B, Ohlsson R, Ekström TJ 1995 Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting. Oncogene 11:221-229
34. Davies SM 1994 Developmental regulation of genomic imprinting of the IGF2 gene in human liver. Cancer Res 54:2560-2562
35. Pavelic K, Bukoviæ D, Paveliæ J 2002 The role of insulin-like growth factor 2 and its receptors in human tumors. Mol Med 8:771-780
36. Li X, Nong Z, Ekström C, Larsson E, Nordlinder H, Hofmann WJ, Trautwein C, Odenthal M, Dienes HP, Ekström TJ, Schirmacher P 1997 Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma. Cancer Res 57:2048-2054
37. Uchida K, Kondo M, Takeda S, Osada H, Takahashi T, Nakao A, Takahashi T 1997 Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma. Mol Carcinog 18:193-198
38. Tang SH, Yang DH, Huang W, Zhou HK, Lu XH, Ye G 2006 Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population. Clin Cancer Res 12:4171-4177
39. Zhan S, Shapiro D, Zhan S, Zhang L, Hirschfeld S, Elassal J, Helman LJ 1995 Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer. J Biol Chem 270:27983-27986