Spontaneous and induced variability of allergens in commodity crops: Ara h 2 in peanut as a case study

Regulatory Toxicology and Pharmacology

Volumn 54, Issue 3 SUPPL., 2009, Pages

  Ozias Akins, Peggy ^a   Ramos, M Laura ^a   Faustinelli, Paola ^a   Chu, Ye ^a   Maleki, Soheila ^b   Thelen, Jay J ^c   Huntley, James ^d   Arias, Katherine ^e   Jordana, Manel ^e  

^a UNIVERSITY OF GEORGIA   (United States)

^b SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^c University of Missouri   (United States)

^d NATIONAL CENTER FOR GENOME RESOURCES   (United States)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

Ara h 2; Arachis duranensis; Arachis hypogaea; Groundnut; Mutagenesis; Peanut; RNA interference; RNA silencing; TILLING

Indexed keywords

ARACHIS HYPOGAEA 2 PROTEIN; FOOD ALLERGEN; IMMUNOGLOBULIN E; UNCLASSIFIED DRUG;

ALLERGENICITY; AMINO ACID SUBSTITUTION; ARTICLE; FOOD ALLERGY; GENE SEQUENCE; GENE SILENCING; GENETIC VARIABILITY; HUMAN; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PEANUT; PLANT GENOME; PRICK TEST; PRIORITY JOURNAL; PROTEOMICS; RNA INTERFERENCE; SEQUENCE ANALYSIS; TRANSGENIC CROP;

2S ALBUMINS, PLANT; ALLERGENS; CROPS, AGRICULTURAL; GLYCOPROTEINS; MUTATION; RNA SPLICING;

ARA; ARACHIS DURANENSIS; ARACHIS HYPOGAEA; GLYCINE MAX;

EID: 67650217867     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.11.002     Document Type: Article

References (27)

1. Astier C., Morisset M., Roitel O., Codreanu F., Jacquenet S., Franck P., Ogier V., Petit N., Proust B., Moneret-Vautrin D., Burks A.W., Bihain B., Sampson H.A., and Kanny G. Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. J. Allergy Clin. Immunol. 118 (2006) 250-256
2. Burks A.W., Williams L.W., Connaughton C., Cockrell G., O'Brien T.J., and Helm R.M. Identification and characterization of a second major peanut allergen, Ara h II, with use of the sera of patients with atopic dermatitis and positive peanut challenge. J. Allergy Clin. Immunol. 90 (1992) 962-969
3. Burks W., Sampson H.A., and Bannon G.A. Peanut allergens. Allergy 53 (1998) 725-730
4. Chatel J.M., Bernard H., and Orson F.M. Isolation and characterization of two complete Ara h 2 isoforms cDNA. Int. Arch. Allergy Immunol. 131 (2003) 14-18
5. Chu, Y., Faustinelli, P., Ramos, M.L., Hajduch, M., Stevenson, S., Thelen, J.J., Maleki, S.J., Ozias-Akins, P., 2008. Reduction of IgE binding and non-promotion of Aspergillus flavus fungal growth by simultaneously silencing Ara h 2 and Ara h 6 in peanut. J. Agric. Food Chem., doi:10.1021/jf802600r.
6. Chung S.-Y., Butts C.L., Maleki S.J., and Champagne E.T. Linking peanut allergenicity to the processes of maturation, curing, and roasting. J. Agric. Food Chem. 51 (2003) 4273-4277
7. Comai L., Young K., Till B.J., Reynolds S.H., Greene E.A., Codomo C.A., Enns L.C., Johnson J.E., Burtner C., Odden A.R., and Henikoff S. Efficient discovery of DNA polymorphisms in natural populations by Ecotilling. Plant J. 37 (2004) 778-786
8. Greene E.A., Codomo C.A., Taylor N.E., Henikoff J.G., Till B.J., Reynolds S.H., Enns L.C., Burtner C., Johnson J.E., Odden A.R., Comai L., and Henikoff S. Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis. Genetics 164 (2003) 731-740
9. Gruber P., Becker W.-M., and Hofmann T. Influence of the Maillard reaction on the allergenicity of rAra h2, a recombinant major allergen from peanut. J. Agric. Food Chem. 53 (2005) 2289-2296
10. Henikoff S., and Comai L. Single-nucleotide mutations for plant functional genomics. Annu. Rev. Plant Biol. 54 (2003) 375-401
11. Henikoff S., Till B.J., and Comai L. TILLING. Traditional mutagenesis meets functional genomics. Plant Physiol. 135 (2004) 630-636
12. Joseph L.M., Hymowitz T., Schmidt M.A., and Herman E.M. Evaluation of Glycine germplasm for nulls of the immunodominant allergen P34/Gly m Bd 30 k. Crop Sci. 46 (2006) 1755-1763
13. Kang I.-H., and Gallo M. Cloning and characterization of a novel peanut allergen Ara h 3 isoform displaying potentially decreased allergenicity. Plant Sci. 172 (2007) 345-353
14. Kochert G., Stalker H., Gimenes M., Galgaro L., Lopes C., and Moore K. RFLP and cytogenetic evidence on the origin and evolution of allotetraploid domesticated peanut, Arachis hypogaea (Leguminosae). Am. J. Bot. 83 (1996) 1282-1291
15. Lehmann K., Schweimer K., Reese G., Randow S., Suhr M., Becker W.-M., Veiths S., and Rosch P. Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions. Biochem. J. 395 (2006) 463-472
16. Maleki S.J., Chung S.-Y., Champagne E.T., and Raufman J.-P. The effects of roasting on the allergenic properties of peanut proteins. J. Allergy Clin. Immunol. 106 (2000) 763-768
17. Ozias-Akins P. Peanut. In: Pua E., and Davey M. (Eds). Biotechnology in Agriculture and Forestry. Transgenic Crops VI vol. 61 (2007), Springer-Verlag, Berlin Heidelberg 81-105
18. Ozias-Akins P., Ramos M.L., and Chu Y. Hypoallergenic foods beyond infant formulas. In: Maleki S., Burks A.W., and Helm R.M. (Eds). Food Allergy (2006), ASM Press, Washington, DC 287-306
19. Ramos M., Fleming G., Chu Y., Akiyama Y., Gallo M., and Ozias-Akins P. Chromosomal and phylogenetic context for conglutin genes in Arachis based on genomic sequence. Mol. Gen. Gen. 275 (2006) 578-592
20. Ramos, M.L., Huntley, J.J., Maleki, S.J., Ozias-Akins, P., 2008. Identification and characterization of a hypoallergenic ortholog of Ara h 2.01. Plant Mol. Biol., doi: 10.1007/s11103-008-9428-z.
21. Restani P., Ballabio C., Corsini E., Fiocchi A., Isoardi P., Magni C., Poiesi C., Terracciano L., and Duranti M. Identification of the basic subunit of Ara h 3 as the major allergen in a group of children allergic to peanuts. Ann. Allergy Asthma Immunol. 94 (2005) 262-266
22. Roth B.M., Pruss G.J., and Vance V.B. Plant viral suppressors of RNA silencing. Virus Res. 102 (2004) 97-108
23. Sen M., Kopper R., Pons L., Abraham E.D., Burks A.W., and Bannon G.A. Protein structure plays a critical role in peanut allergen stability and may determine immunodominant IgE-binding epitopes. J. Immunol. 169 (2002) 882-887
24. Simpson C.E. Use of wild Arachis species/introgression of genes into A. Hypogaea L. Peanut Sci. 28 (2001) 114-116
25. Stanley J.S., King N., Burks A.W., Huang S.K., Sampson H., Cockrell G., Helm R.M., West C.M., and Bannon G.A. Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2. Arch. Biochem. Biophys. 342 (1997) 244-253
26. Teuber S., Beyer K., Comstock S., and Wallowitz M. The big eight foods: clinical and epidemiological overview. In: Maleki S., Burks A., and Helm R. (Eds). Food Allergy (2006), ASM Press, Washington, DC 49-79
27. Vaucheret H. Post-transcriptional small RNA pathways in plants: mechanisms and regulations. Genes Dev. 20 (2006) 759-771