Serum Phenylalanine Concentration as a Marker of Liver Function in Obese Patients before and after Bariatric Surgery

Obesity Surgery

Volumn 19, Issue 7, 2009, Pages 883-889

  Swierczynski, Julian ^a   Sledzinski, Tomasz ^a   Slominska, Ewa ^a   Smolenski, Ryszard ^a   Sledzinski, Zbigniew ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Bariatric surgery; Morbid obesity; NAFLD; NASH; Serum phenylalanine

Indexed keywords

ALANINE AMINOTRANSFERASE; BIOLOGICAL MARKER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHENYLALANINE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; BARIATRIC SURGERY; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FATTY LIVER; FEMALE; GASTRIC BANDING; GASTROPLASTY; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER DYSFUNCTION; LIVER FUNCTION; MALE; OBESITY; PARAMETER; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BARIATRIC SURGERY; BIOLOGICAL MARKERS; FEMALE; HUMANS; LIVER; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; OBESITY; PHENYLALANINE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 67650095949     PISSN: 09608923     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11695-008-9521-z     Document Type: Article

References (34)

1. RH Pearl GH Clowes S Bosari 1987 Amino acid clearance in cirrhosis. A predictor of postoperative morbidity and mortality Arch Surg 122 468 473 (Pubitemid 17051877)
2. 13C]phenylalanine Am J Physiol 259 E835 E843
3. M Heberer H Talke KP Maier 1980 Metabolism of phenylalanine in liver diseases Klin Wochenschr 58 1189 1196 (Pubitemid 10024476)
4. E Holm O Sedlaczek E Grips 1999 Amino acid metabolism in liver disease Curr Opin Clin Nutr Metab Care 2 47 53 (Pubitemid 129628626)
5. 13C]-phenylalaniane oxidation as a measure of hepatocyte functional capacity in end-stage liver disease Am J Surg 173 270 273
6. 13C]phenylalanine breast test J Gastroenterol 38 1086 1090 (Pubitemid 38016371)
7. 13C] phenylalanine breath test reflects histological changes in the liver J Surg Res 114 120 125 (Pubitemid 37237675)
8. BA Neuschwander-Tetri SH Caldwell 2003 Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference Hepathology 37 1202 1219 (Pubitemid 36538699)
9. M Charlton 2004 Nonalcoholic fatty liver disease: a review of current understanding and future impact Clin Gastroenterol Hepatol 2 1048 1058 (Pubitemid 40037633)
10. T Poynard V Ratziu F Charlotte 2006 Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease BMC Gastroenterol 6 34
11. LA Adams P Angulo KD Lindor 2005 Nonalcoholic fatty liver disease CMAJ 172 899 905 (Pubitemid 40543601)
12. FS Papadia GM Marinari G Camerini 2004 Liver damage in severely obese patients: a clinical-biochemical-morphologic study on 1,000 liver biopsies Obes Surg 14 952 958 (Pubitemid 39093470)
13. S Shalhub A Parsee SF Gallagher 2004 The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients Obes Surg 14 54 59 (Pubitemid 38130716)
14. M Moretto C Kupski CC Mottin 2003 Hepatic steatosis in patients undergoing bariatric surgery and its relationship to body mass index and co-morbidities Obes Surg 13 622 624 (Pubitemid 36951745)
15. PL Liew WJ Lee YCh Lee 2006 Hepatic histopathology of morbid obesity: concurrence of other forms of chronic liver disease Obes Surg 16 1584 1593
16. JB Dixon PS Bhathal PE O'Brien 2006 Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentration are associated with histologic improvement Obes Surg 16 1278 1286 (Pubitemid 44671797)
17. JA Talwalkar 2002 Motion-all patients with NASH need to have a liver biopsy: arguments for the motion Can J Gastroenterol 16 718 721 (Pubitemid 35402229)
18. J Laurin 2002 Motion-all patients with NASH need to have a liver biopsy: arguments against the motion Can J Gastroenterol 16 722 726 (Pubitemid 35402230)
19. Y Chang S Ryu E Sung 2007 Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease Clin Chem 53 686 692 (Pubitemid 46580239)
20. P Felig E Marliss GF Cahill 1969 Plasma amino acid levels and insulin secretion in obesity N Engl J Med 281 811 816
21. B Caballero N Finer RJ Wurtman 1988 Plasma amino acids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements Metabolism 37 672 676 (Pubitemid 18168020)
22. JM Clark AR Alkhuraishi SF Solga 2005 Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease Obes Res 13 180 186
23. J Swierczynski J Korczynska E Goyke 2005 Serum hepatocyte growth factor concentration in obese women decreases after vertical banded gastroplasty Obes Surg 15 803 808 (Pubitemid 40904870)
24. WT Friedewald RI Levy DS Fredrickson 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 499 502
25. DR Matthews JP Hosker AS Rudenski 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419 (Pubitemid 15018832)
26. S Palova J Charvat J Masopust 2007 Changes in the plasma amino acid profile in anorexia nervosa J Int Med Res 35 389 394 (Pubitemid 46971360)
27. G Marchesini M Brizi AM Morselli-Labate 1999 Association of nonalcoholic fatty liver disease with insulin resistance Am J Med 107 450 455 (Pubitemid 29528333)
28. JM Clark FL Brancati AM Diehl 2003 The prevalence and etiology of elevated aminotransferase levels in the United States Am J Gastroenterol 98 960 967 (Pubitemid 36733754)
29. MG Myers MA Cowley H Munzberg 2008 Mechanisms of leptin action and leptin resistance Annu Rev Physiol 70 537 556 (Pubitemid 351738191)
30. V Nobili M Manco P Ciampalini 2006 Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease Eur J Endocrinol 155 735 743 (Pubitemid 44857498)
31. S Chitturi G Farrell L Frost 2002 Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotixicity? Hepatology 36 403 409 (Pubitemid 34810360)
32. LM Kaplan 1998 Leptin, obesity, and liver disease Gastroenterology 115 997 1001 (Pubitemid 28452948)
33. L Zabrocka S Raczynska E Goyke 2004 BMI is the main determinant of the circulating leptin in women after vertical banded gastroplasty Obes Res 12 505 512 (Pubitemid 41132530)
34. MA Maggard LR Shugarman M Suttorp 2005 Meta-analysis: surgical treatment of obesity Ann Intern Med 142 547 559