Evaluation of Treadmill Exercise in a Lower Body Negative Pressure Chamber as a Countermeasure for Weightlessness-Induced Bone Loss: A Bed Rest Study with Identical Twins

Journal of Bone and Mineral Research

Volumn 18, Issue 12, 2003, Pages 2223-2230

  Smith, Scott M ^a   Davis Street, Janis E ^b   Fesperman, J Vernell ^b   Calkins, D S ^c   Bawa, Maneesh ^d   Macias, Brandon R ^d   Meyer, R Scott ^d   Hargens, Alan R ^d  

^a NASA JOHNSON SPACE CENTER   (United States)

^b Enterprise Advisory Services Inc   (United States)

^c WYLE LABORATORIES   (United States)

^d UCSD MEDICAL CENTER   (United States)

Author keywords

Bed rest; Bone markers; Bone resorption; Simulated weightlessness; Spaceflight

Indexed keywords

CALCIUM; COLLAGEN; DEOXYPYRIDINOLINE; PEPTIDE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BED REST; BLOOD SAMPLING; BONE METABOLISM; CALCIUM BLOOD LEVEL; CALCIUM METABOLISM; CALCIUM URINE LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS LINKING; HUMAN; HUMAN EXPERIMENT; LOWER BODY NEGATIVE PRESSURE; MALE; MONOZYGOTIC TWINS; NORMAL HUMAN; OSTEOLYSIS; OUTCOMES RESEARCH; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SIMULATION; SITTING; SPACE FLIGHT; STATISTICAL SIGNIFICANCE; TREADMILL EXERCISE; URINALYSIS; WEIGHTLESSNESS;

ALKALINE PHOSPHATASE; BED REST; BIOLOGICAL MARKERS; BONE DISEASES, METABOLIC; CALCIFEDIOL; CALCITRIOL; CALCIUM; EXERCISE TEST; HUMANS; MALE; OSTEOCALCIN; PARATHYROID HORMONE; PATIENT SELECTION; POSTURE; SPACE FLIGHT; SUPINE POSITION; TWINS, MONOZYGOTIC; WEIGHTLESSNESS;

EID: 0345305729     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.12.2223     Document Type: Article

References (47)

1. LeBlanc A, Schneider V, Shackelford L 2000 Bone mineral and lean tissue loss after long duration space flight. J Musculoskeletal Neuron Interact 1:157-160.
2. Vico L, Collet P, Guignandon A, Lafage-Proust M-H, Thomas T, Rehaillia M, Alexandre C 2000 Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355:1607-1611.
3. Oganov V, Rakhmanov A, Novikov V, Zatsepin S, Rodionova S, Cann C 1991 The state of human bone tissue during space flight. Acta Astronautica 23:129-133.
4. Smith MC Jr, Rambaut PC, Vogel JM, Whittle MW 1977 Bone mineral measurement - experiment M078. In: Johnston RS, Dietlein LF (eds.) Biomedical Results from Skylab (NASA SP-377). National Aeronautics and Space Administration, Washington, DC, USA, pp. 183-190.
5. Whalen RT, Carter DR, Steele CR 1988 Influence of physical activity on the regulation of bone density. J Biomech 21:825-837.
6. Cavanagh PR, Davis BL, Miller TA 1992 A biomechanical perspective on exercise countermeasures for long term spaceflight. Aviat Space Environ Med 63:482-485.
7. Davis BL, Cavanagh PR, Sommer HJ III, Wu G 1996 Ground reaction forces during locomotion in simulated microgravity. Aviat Space Environ Med 67:235-242.
8. Morey-Holton E, Whalen R, Arnaud S, Van Der Meulen M 1996 The skeleton and its adaptation to gravity. In: Fregly M, Blatteis C (eds.) Environmental Physiology, vol. 1. Oxford University Press, New York, NY, USA, pp. 691-719.
9. Whalen R 1993 Musculoskeletal adaptation to mechanical forces on Earth and in space. Physiologist 36(Suppl 1):S127-130.
10. Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Shih CY, Nillen JL, Davis-Street JE, Rice BL, Lane HW 1999 Calcium metabolism before, during, and after a 3-mo spaceflight: Kinetic and biochemical changes. Am J Physiol 277:R1-10.
11. Goldstein SA, Kuhn JL, Hollister SJ, Goulet RW, Loubert PV, Sweet K, Matthews LS 1988 The relationship between experimentally controlled loads and trabecular bone remodeling. Trans Orthop Res Soc 13:102.
12. Heinonen A, Kannus P, Sievanen H, Pasanen M, Oja P, Vuori I 1999 Good maintenance of high-impact activity-induced bone gain by voluntary, unsupervised exercises: An 8-month follow-up of a randomized controlled trial. J Bone Miner Res 14:125-128.
13. Taaffe DR, Robinson TL, Snow CM, Marcus R 1997 High-impact exercise promotes bone gain in well-trained female athletes. J Bone Miner Res 12:255-260.
14. Hargens AR, Whalen RT, Watenpaugh DE, Schwandt DF, Krock LP 1991 Lower body negative pressure to provide load bearing in space. Aviat Space Environ Med 62:934-937.
15. Boda WL, Watenpaugh DE, Ballard RE, Hargens AR 2000 Supine lower body negative pressure exercise simulates metabolic and kinetic features of upright exercise. J Appl Physiol 89:649-654.
16. Watenpaugh DE, Hargens AR 1996 The cardiovascular system in microgravity. In: Fregly MJ, Blatteis CM (eds.) Handbook of Physiology, vol. 1. Oxford University Press, New York, NY, USA, pp. 631-674.
17. Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, Delp MD 2000 Alterations in skeletal perfusion with simulated microgravity: A possible mechanism for bone remodeling. J Appl Physiol 89:1046-1054.
18. Hargens AR, Watenpaugh DE, Breit GA 1992 Control of circulatory function in altered gravitational fields. Physiologist 35(Suppl 1):S80-S83.
19. Schwandt DF, Whalen RT, Watenpaugh DE, Parazynski SE, Hargens AR 1991 Development of exercise devices to minimize musculoskeletal and cardiovascular deconditioning in microgravity. Physiologist 34(Suppl 1):S189-S190.
20. Murthy G, Watenpaugh DE, Ballard RE, Hargens AR 1994 Exercise against lower body negative pressure as a countermeasure for cardiovascular and musculoskeletal deconditioning. Acta Astonautica 33:89-96.
21. Watenpaugh DE, Ballard RE, Schneider SM, Lee SM, Ertl AC, William JM, Boda WL, Hutchinson KJ, Hargens AR 2000 Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol 89:218-227.
22. Lee SM, Bennett BS, Hargens AR, Watenpaugh DE, Ballard RE, Murthy G, Ford SR, Fortney SM 1997 Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. Med Sci Sports Exerc 29:892-900.
23. Arnaud S, Sherrard D, Maloney N, Whalen R, Fung P 1992 Effects of 1-week head-down tilt bed rest on bone formation and the calcium endocrine system. Aviat Space Environ Med 63:14-20.
24. Lueken SA, Arnaud SB, Taylor AK, Baylink DJ 1993 Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res 8:1433-1438.
25. Donaldson C, Hulley S, Vogel J, Hattner R, Bayers J, McMillan D 1970 Effect of prolonged bed rest on bone mineral. Metabolism 19:1071-1084.
26. LeBlanc AD, Schneider VS, Evans HJ, Engelbretson DA, Krebs JM 1990 Bone mineral loss and recovery after 17 weeks of bed rest. J Bone Miner Res 5:843-850.
27. Zerwekh JE, Ruml LA, Gottschalk F, Pak CY 1998 The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects. J Bone Miner Res 13:1594-1601.
28. LeBlanc A, Schneider V, Spector E, Evans H, Rowe R, Lane H, Demers L, Lipton A 1995 Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest. Bone 16(Suppl 4):301S-304S.
29. Hwang TIS, Hill K, Schneider V, Pak CYC 1988 Effect of prolonged bedrest on the propensity for renal stone formation. J Clin Endocrinol Metab 66:109-112.
30. Whedon GD 1984 Disuse osteoporosis: Physiological aspects. Calcif Tissue Int 36:S146-S150.
31. Dietrick JE, Whedon GD, Shorr E 1948 Effects of immobilization upon various metabolic and physiologic functions of normal men. Am J Med 4:3-36.
32. Hsiung CS, Andrade JD, Costa R, Ash KO 1997 Minimizing interferences in the quantitative multielement analysis of trace elements in biological fluids by inductively coupled plasma mass spectrometry. Clin Chem 43:2303-2311.
33. Smith SM, Nillen JL, Leblanc A, Lipton A, Demers LM, Lane HW, Leach CS 1998 Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 83:3584-3591.
34. Wallace JD, Cuneo RC, Lundberg PA, Rosen T, Jorgensen JO, Longobardi S, Keay N, Sacca L, Christiansen JS, Bengtsson BA, Sonksen PH 2000 Responses of markers of bone and collagen turnover to exercise, growth hormone (GH) administration, and GH withdrawal in trained adult males. J Clin Endocrinol Metab 85:124-133.
35. Welsh L, Rutherford OM, James I, Crowley C, Comer M, Wolman R 1997 The acute effects of exercise on bone turnover. Int J Sports Med 18:247-251.
36. Langberg H, Skovgaard D, Asp S, Kjaer M 2000 Time pattern of exercise-induced changes in type I collagen turnover after prolonged endurance exercise in humans. Calcif Tissue Int 67:41-44.
37. Brahm H, Piehl-Aulin K, Ljunghall S 1996 Biochemical markers of bone metabolism during distance running in healthy, regularly exercising men and women. Scand J Med Sci Sports 6:26-30.
38. Creighton DL, Morgan AL, Boardley D, Brolinson PG 2001 Weight-bearing exercise and markers of bone turnover in female athletes. J Appl Physiol 90:565-570.
39. Brooke-Wavell K, Jones PR, Hardman AE, Tsuritani I, Yamada Y 2001 Commencing, continuing and stopping brisk walking: Effects on bone mineral density, quantitative ultrasound of bone and markers of bone metabolism in postmenopausal women. Osteoporos Int 12:581-587.
40. Iwamoto J, Takeda T, Ichimura S 2002 Relationships among physical activity, metacarpal bone mass, and bone resorption marker in 70 healthy adult males. J Orthop Sci 7:6-11.
41. Collet P, Uebelhart D, Vico L, Moro L, Hartmann D, Roth M, Alexandre C 1997 Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans. Bone 20:547-551.
42. Caillot-Augusseau A, Lafage-Proust M-H, Soler C, Pernod J, Dubois F, Alexandre C 1998 Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95). Clin Chem 44:578-585.
43. Smith SM, Davis-Street JE, Rice BL, Nillen JL, Gillman PL, Block G 2001 Nutritional status assessment in semiclosed environments: Ground-based and space flight studies in humans. J Nutr 131: 2053-2061.
44. Vico L, Chappard D, Alexandre C, Palle S, Minaire P, Riffat G, Morukov B, Rakhmanov S 1987 Effects of a 120 day period of bed-rest on bone mass and bone cell activities in man: Attempts at countermeasure. Bone Miner 2:383-394.
45. Smith SM, Heer M 2002 Calcium and bone metabolism during space flight. Nutrition 18:849-852.
46. Heer M, Kamps N, Biener C, Korr C, Boerger A, Zittermann A, Stehle P, Drummer C 1999 Calcium metabolism in microgravity. Eur J Med Res 4:357-360.
47. Caillot-Augusseau A, Vico L, Heer M, Voroviev D, Souberbielle J-C, Zitterman A, Alexandre C, Lafage-Proust M-H 2000 Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: Observations in two cosmonauts. Clin Chem 46:1136-1143.