Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression

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Volumn 31, Issue 3, 2009, Pages 102-106

  Veselý, Pavel ^a   Rösel, Daniel ^b   Paňková, Daniela ^b   Tolde, Ondřej ^b   Blase, Chris ^c   Matoušková, Eva ^b   Folk, Petr ^b   Brábek, Jan ^b   Bereiter Hahn, Juergen ^c  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Breast carcinoma; Cinemicroscopy; Dynamic morphology; Malignancy progression

Indexed keywords

BREAST CANCER CELLS; BREAST CARCINOMA; CINEMICROSCOPY; INVASIVENESS; MALIGNANCY PROGRESSION; MORPHOTYPES; NUTRITIONAL STRESS; PHASE-CONTRAST MICROSCOPY; SALT SOLUTION; TETRADECANOYLPHORBOL 13 ACETATES;

CONFOCAL MICROSCOPY; MORPHOLOGY;

CELL MEMBRANES;

BALANCED SALT SOLUTION; GELATIN; MATRIGEL; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CELL GROWTH; CHRONIC STRESS; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; INCIDENCE; MORPHOTYPE; MOUSE; NONHUMAN; NUTRITIONAL DISORDER; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; STANDARD;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, PHASE-CONTRAST; MICROSCOPY, VIDEO;

EID: 67650083097     PISSN: 01610457     EISSN: None     Source Type: Journal    
DOI: 10.1002/sca.20146     Document Type: Article

References (14)

1. Brozova M, Kleibl Z, Netikova I, Sevcik J, Scholzova E, et al.: Establishment, growth and in vivo differentiation of a new clonal human cell line, EM-G3, derived from breast cancer progenitors. Breast Cancer Res Treat 103, 247-257 (2007). (Pubitemid 46789138)
2. Cavanna T, Pokorná E, Vesely P, Gray C, Zicha D: Evidence for protein 4.1B acting as a metastasis suppressor. J Cell Sci 120, 606-616 (2007). (Pubitemid 46437895)
3. Clark EA, Golub TR, Lander ES, Hynes RO: Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406, 532-535 (2000). (Pubitemid 30625739)
4. Decaestecker C, Debeir O, Van Ham P, Kiss R: Can antimigratory drugs be screened in vitro? A review of 2D and 3D assays for the quantitative analysis of cell migration. Med Res Rev 27, 149-176 (2007). (Pubitemid 46281145)
5. Hazgui S, Bonnet N, Cutrona J, Nawrocki-Raby B, Polette M, et al.: 3D culture model and computer-assisted videomicroscopy to analyze migratory behavior of noninvasive and invasive bronchial epithelial cells. Am J Physiol Cell Physiol 289, 1547-1552 (2005). (Pubitemid 41636359)
6. Kerbel RS, Man MS, Dexter D: A model of human cancer metastasis: extensive spontaneous and artificial metastasis of a human pigmented melanoma and derived variant sublines in nude mice. J Natl Cancer Inst 72, 93-108 (1984). (Pubitemid 14159234)
7. Pauli BU, Anderson SN, Memoli VA, Kuettner KE: Development of an in vitro and in vivo epithelial tumor model for the study of invasion. Cancer Res 40, 4571-4580 (1980). (Pubitemid 11199723)
8. Pokorná E, Zicha D, Chaloupková A, Matousková E, Vesely P: Two dynamic morphotypes of sarcoma cells, asymmetric stellate and triangle with leading lamella, are related to malignancy. Folia Biol (Praha) 49, 33-39 (2003). (Pubitemid 36240659)
9. Rösel D, Brábek J, Tolde O, Mierke CT, Zitterbart DP, et al.: Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces. Mol Cancer Res 6, 1410-1420 (2008).
10. Seftor EA, Seftor RE, Hendrix MJ: Selection of invasive and metastatic subpopulations from a heterogeneous human melanoma cell line. Biotechniques 9, 324-331 (1990). (Pubitemid 20281292)
11. Selicharová I, Smutná K, Sanda M, Ubik K, Matousková E, et al.: 2-DE analysis of a new human cell line EM-G3 derived from breast cancer progenitor cells and comparison with normal mammary epithelial cells. Proteomics 7, 1549-1559 (2007). (Pubitemid 46775885)
12. Terranova VP, Hic S, Diflorio RM, Lyall RM: Tumor cell metastasis. Crit Rev Oncol Hematol 5, 87-114 (1986).
13. Vesely P, Blase C, Matouskova E, Bereiter-Hahn J: Arising podosomal structures are associated with neoplastic cell morphological morphotype induced by the microenvironment. Anticancer Res 26, 967-972 (2006).
14. Vesely P, Boyde A: Fast intracellular motion in the living cell by video rate reflection confocal laser scanning microscopy. J Anat 198, 641-649 (2001). (Pubitemid 32633523)