Sequence learning is preserved in individuals with cerebellar degeneration when the movements are directly cued

Journal of Cognitive Neuroscience

Volumn 21, Issue 7, 2009, Pages 1302-1310

  Spencer, Rebecca M C ^a,b   Ivry, Richard B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASSOCIATION; CEREBELLUM DEGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LEARNING; MALE; MOVEMENT PERCEPTION; PRIORITY JOURNAL; STIMULUS RESPONSE; TASK PERFORMANCE; WORKING MEMORY;

AGED; ASSOCIATION LEARNING; CEREBELLAR ATAXIA; CUES; FEMALE; HUMANS; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; MOVEMENT; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; REACTION TIME;

EID: 67650082743     PISSN: 0898929X     EISSN: 15308898     Source Type: Journal    
DOI: 10.1162/jocn.2009.21102     Document Type: Article

References (41)

1. Akshoomoff, N. A., & Courchesne, E. (1992). A new role for the cerebellum in cognitive operations. Behavioral Neuroscience, 106, 731-738.
2. Albert, N., Weigelt, M., Hazeltine, E., & Ivry, R. B. (2007). Target selection during bimanual reaching to direct cues is unaffected by the perceptual similarity of the targets. Journal of Experimental Psychology: Human Perception and Performance, 33, 1107-1116.
3. Bischoff-Grethe, A., Ivry, R. B., & Grafton, S. T. (2002). Cerebellar involvement in response reassignment rather than attention. Journal of Neuroscience, 22, 546-553.
4. Chaudhuri, A., & Behan, P. (2004). Fatigue in neurological disorders. Lancet, 363, 978-988.
5. Courchesne, E., Townsend, J., Akshoomoff, N. A., Saitoh, O., Yeung-Courchesne, R., Lincoln, A. J., et al. (1994). Impairment in shifting attention in autistic and cerebellar patients. Behavioral Neuroscience, 108, 848-865.
6. Diedrichsen, J., Verstynen, T., Lehman, S. L., & Ivry, R. B. (2005). Cerebellar involvement in anticipating the consequences of self-produced actions during bimanual movement. Journal of Neurophysiology, 93, 801-812.
7. Doyon, J., Gaudreau, D., Laorce, R., Castonguay, M., Bedard, P. J., Bedard, F., et al. (1997). Role of the striatum, cerebellum, and frontal lobes in the learning of a visuomotor sequence. Brain and Cognition, 34, 218-245.
8. Doyon, J., Song, A. W., Karni, A., Lalonde, F., Adams, M. M., & Ungerleider, L. G. (2002). Experience-dependent changes in cerebellar contributions to motor sequence learning. Proceedings of the National Academy of Sciences, U.S.A., 99, 1017-1022.
9. Gerwig, M., Dimitrova, A., Kolb, F. P., Maschke, M., Brol, B., Kunnel, A., et al. (2003). Comparison of eyeblink conditioning in patients with superior and posterior inferior cerebellar lesions. Brain, 126, 71-94.
10. Gomez-Beldarrain, M., Garcia-Monco, J. C., Rubio, B., & Pascual-Leone, A. (1998). Effect of focal cerebellar lesions on procedural learning in the serial reaction time task. Experimental Brain Research, 120, 25-30.
11. Grafton, S., Hazeltine, E., & Ivry, R. (1995). Functional mapping of sequence learning in normal humans. Journal of Cognitive Neuroscience, 7, 497-510.
12. Grafton, S., Hazeltine, E., & Ivry, R. B. (1998). Abstract and effector-specific representations of motor sequences identified with PET. Journal of Neuroscience, 18, 9420-9428.
13. Hazeltine, E., Diedrichsen, J., Kennerley, S., & Ivry, R. B. (2003). Bimanual cross-talk during reaching movements is primarily related to response selection, not the specification of motor parameters. Psychological Research, 67, 56-70.
14. Hazeltine, E., Grafton, S. T., & Ivry, R. B. (1997). Attention and stimulus characteristics determine the locus of motor-sequence encoding: A PET study. Brain, 120, 123-140.
15. Imamizu, H., Miyauchi, S., Tamada, T., Sasaki, Y., Takino, R., Putz, B., et al. (2000). Human cerebellar activity reflecting an acquired internal model of a new tool. Nature, 403, 192-195.
16. Ivry, R. B., Diedrichsen, J., Spencer, R. M. C., Hazeltine, E., & Semjen, A. (2004). A cognitive neuroscience perspective on bimanual coordination and interference. In S. P. Swinnen & J. Duyens (Eds.), Interlimb coordination (pp. 259-295). Norwell, MA: Kluwer Academic.
17. Ivry, R. B., & Fiez, J. A. (2000). Cerebellar contributions to cognition and imagery. In M. S. Gazzaniga (Ed.), The new cognitive neurosciences (pp. 999-1011). Cambridge, MA: MIT Press.
18. Keele, S. W., Ivry, R. B., Mayr, U., Hazeltine, E., & Heuer, H. (2003). The cognitive and neural architecture of sequence representation. Psychological Review, 110, 316-339.
19. Keele, S. W., Jennings, P., Jones, S., Caulton, D., & Cohen, A. (1995). On the modularity of sequence representation. Journal of Motor Behavior, 27, 17-30.
20. Kelly, R. M., & Strick, P. L. (2003). Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. Journal of Neuroscience, 23, 8432-8444.
21. Klockgether, T. (2000). Handbook of ataxia disorders. New York: Marcel Dekker.
22. Lu, X., Hikosaka, O., & Miyachi, S. (1998). Role of monkey cerebellar nuclei in skill for sequential movement. Journal of Neurophysiology, 79, 2245-2254.
23. Martin, T. A., Keating, J. G., Goodkin, H. P., Bastian, A. J., & Thach, W. T. (1996). Throwing while looking through prisms: I. Focal olivocerebellar lesions impair adaptation. Brain, 119, 1183-1198.
24. Maschke, M., Gomez, C. M., Ebner, T. J., & Konczak, J. (2004). Hereditary cerebellar ataxia progressively impairs force adaptation during goal-directed arm movements. Journal of Neurophysiology, 91, 230-238.
25. Miller, B. T., & D'Esposito, M. (2005). Searching for "the Top" in Top-Down Control. Neuron, 48, 535-538.
26. Molinari, M., Leggio, M. G., Solida, A., Ciorra, R., Misciangna, S., Silveri, M. C., et al. (1997). Cerebellum and procedural learning: Evidence from focal cerebellar lesions. Brain, 120, 1753-1762.
27. Morton, S. M., & Bastian, A. J. (2004). Prism adaptation during walking generalizes to reaching and requires the cerebellum. Journal of Neurophysiology, 92, 2497-2509.
28. Nissen, M. J., & Bullemer, P. (1987). Attentional requirements of learning: Evidence from performance measures. Cognitive Psychology, 19, 1-32.
29. Nixon, P. D., & Passingham, R. E. (2000). The cerebellum and cognition: Cerebellar lesions impair sequence learning but not conditional visuomotor learning in monkeys. Neuropsychologia, 38, 1054-1072.
30. Pascual-Leone, A., Grafman, J., Clark, K., Stewart, M., Massaquoi, S., Lou, J.-S., et al. (1993). Procedural learning in Parkinson's disease and cerebellar degeneration. Annals of Neurology, 34, 594-602.
31. Ramnani, N. (2006). The primate cortico-cerebellar system: Anatomy and function. Nature Reviews Neuroscience, 7, 511-522.
32. Ravizza, S. M., & Ivry, R. B. (2001). Comparison of the basal ganglia and cerebellum in shifting attention. Journal of Cognitive Neuroscience, 13, 285-297.
33. Raymond, J. L., Lisberger, S. G., & Mauk, M. D. (1996). The cerebellum: A neuronal learning machine? Science, 272, 1126-1131.
34. Richter, S., Matthies, K., Ohde, T., Dimitrova, A., Gizewski, E., Beck, A., et al. (2004). Stimulus-response versus stimulus-stimulus-response learning in cerebellar patients. Experimental Brain Research, 158, 438-449.
35. Seidler, R. D., Purushotham, A., Kim, S. G., Ugurbil, K., Willingham, D., & Ashe, J. (2002). Cerebellum activation associated with performance change but not motor learning. Science, 296, 2043-2046.
36. Shin, J. C., & Ivry, R. (2003). Spatial and temporal sequence learning in patients with Parkinson's disease or cerebellar lesions. Journal of Cognitive Neuroscience, 15, 1232-1243.
37. Smith, M. A., & Shadmehr, R. (2005). Intact ability to learn internal models of arm dynamics in Huntington's disease but not cerebellar degeneration. Journal of Neurophysiology, 93, 2809-2821.
38. Timmann, D., Drepper, J., Maschke, M., Kolb, F. P., Böring, D., Thilmann, A. F., et al. (2002). Motor deficits cannot explain impaired cognitive associative learning in cerebellar patients. Neuropsychologia, 40, 788-800.
39. Trouillas, P., Takayanagi, T., Hallett, M., Currier, R. D., Subramony, S. H., Wessel, K., et al. (1997). International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. Journal of Neurological Sciences, 145, 205-211.
40. van der Graff, F. H. C. E., Maguire, R. P., Leenders, K. L., & de Jong, B. M. (2006). Cerebral activation related to implicit sequence learning in a Double Serial Reaction Time task. Brain Research, 1081, 179-190.
41. Wise, S. P., di Pellegrino, G., & Boussaoud, D. (1996). The premotor cortex and nonstandard sensorimotor mapping. Canadian Journal of Physiology and Pharmacology, 74, 469-482.