A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS

International Journal of Cancer

Volumn 125, Issue 3, 2009, Pages 656-661

  Preuss, Klaus Dieter ^a   Pfreundschuh, Michael ^a,b   Ahlgrimm, Manfred ^a   Fadle, Natalie ^a   Regitz, Evi ^a   Murawski, Niels ^a   Grass, Sandra ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Antigen identification; Antigenic stimulation; Monoclonal gammopathy of undetermined significance; Multiple myeloma; Paraprotein

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G3; PARAPROTEIN; PARATARG 7 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN TISSUE; MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE; MULTIPLE MYELOMA; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SCREENING; SEQUENCE ANALYSIS; SERUM; WESTERN BLOTTING;

BLOOD PROTEINS; BLOTTING, WESTERN; ELECTROPHORESIS; FOLLOW-UP STUDIES; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MEMBRANE PROTEINS; MULTIPLE MYELOMA; PARAPROTEINEMIAS; PARAPROTEINS;

EID: 67650081234     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24427     Document Type: Article

References (28)

1. Jack HM, Beck-Engeser G, Lee G, Wofsy D, Wabl M. Tumorigenesis mediated by an antigen receptor. Proc Natl Acad Sci USA 1992;89:8482-6.
2. Friedman DF, Cho EA, Goldman J, Carmack CE, Besa EC, Hardy RR, Silberstein LE. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. J Exp Med 1991;174:525-37.
3. Seligmann M, Brouet JC. Antibody activity of human myeloma globulins. Semin Hematol 1973;10:163-77.
4. Colwell NS, Tollefsen DM, Blinder MA. Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder. Br J Haematol 1997;97:219-26.
5. Konrad RJ, Kricka LJ, Goodman DB, Goldman J, Silberstein LE. Brief report: myeloma-associated paraprotein directed against the HIV-1 p24 antigen in an HIV-1-seropositive patient. N Engl J Med 1993;328:1817-9.
6. Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pfreundschuh M. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 1995;92:11810-3.
7. Xie X, Schmits R, Renner C, Preuss D, Kubuschok B, Pfreundschuh M. Systematic search and molecular characterization of the antigenic targets of myeloma immunoglobulins: a monoclonal IgA from a female patient targeting sperm-specific cylicin II. Cancer Immun 2001;1:11.
8. Preuss KD, Held G, Kubuschok B, Hung CZ, Malatsidze N, Wagner M, Pfreundschuh M. Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS. Int J Cancer 2007;121:459-61.
9. Pfohler C, Preuss KD, Tilgen W, Stark A, Regitz E, Fadle N, Pfreundschuh M. Mitofilin and titin as target antigens in melanoma-associated retinopathy. Int J Cancer 2007;120:788-95.
10. Preuss KD, Regitz E, Neumann F, Pfreundschuh M. B-cell epitopes from the cancer testis antigen NY-ESO-1. Int J Cancer 2006;118:253.
11. Cao W, Zhang B, Liu Y, Li H, Zhang S, Fu L, Niu Y, Ning L, Cao X, Liu Z, Sun B. High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival. Am J Clin Pathol 2007;128:430-6.
12. Cao WF, Zhang LY, Liu MB, Tang PZ, Liu ZH, Sun BC. Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray. Hum Pathol 2007;38:747-52.
13. Cui Z, Zhang L, Hua Z, Cao W, Feng W, Liu Z. Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma. Oncol Rep 2007;17:829-33.
14. Kirchhof MG, Chau LA, Lemke CD, Vardhana S, Darlington PJ, Marquez ME, Taylor R, Rizkalla K, Blanca I, Dustin ML, Madrenas J. Modulation of T cell activation by stomatin-like protein 2. J Immunol 2008;181:1927-36.
15. Seligmann M, Sassy C, Chevalier A. A human IgG myeloma protein with anti- 2 macroglobulin antibody activity. J Immunol 1973;110:85-90.
16. Dighiero G, Guilbert B, Fermand JP, Lymberi P, Danon F, Avrameas S. Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations. Blood 1983;62:264-70.
17. Dellagi K, Brouet JC, Perreau J, Paulin D. Human monoclonal IgM with autoantibody activity against intermediate filaments. Proc Natl Acad Sci USA 1982;79:446-50.
18. Braun PE, Frail DE, Latov N. Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy. J Neurochem 1982;39:1261-5.
19. Kritzman J, Kunkel HG, McCarthy J, Mellors RC. Studies of a Waldenstrom-type macroglobulin with rheumatoid factor properties. J Lab Clin Med 1961;57:905-17.
20. Kilgore LL, Patterson BW, Parenti DM, Fisher WR. Immune complex hyperlipidemia induced by an apolipoprotein-reactive immunoglobulin A paraprotein from a patient with multiple myeloma. Characterization of this immunoglobulin. J Clin Invest 1985;76:225-32.
21. Redmon B, Pyzdrowski KL, Elson MK, Kay NE, Dalmasso AP, Nuttall FQ. Hypoglycemia due to an insulin-binding monoclonal antibody in multiple myeloma. N Engl J Med 1992;326:994-8.
22. Mills LE, Brettman LR, Jentoft JE, Viner ED, Bernier GM. Crystallocryoglobulinemia resulting from human monoclonal antibodies to albumin. Ann Intern Med 1983;99:601-4.
23. Trimarchi F, Benvenga S, Fenzi G, Mariotti S, Consolo F. Immunoglobulin binding of thyroid hormones in a case of Waldenstrom's macroglobulinemia. J Clin Endocrinol Metab 1982;54:1045-50.
24. Sompuram SR, Bastas G, Vani K, Bogen SA. Accurate identification of paraprotein antigen targets by epitope reconstruction. Blood 2008;111:302-8.
25. Sahota SS, Leo R, Hamblin TJ, Stevenson FK. Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells. Blood 1997;89:219-26.
26. Kosmas C, Stamatopoulos K, Stavroyianni N, Zoi K, Belessi C, Viniou N, Kollia P, Yataganas X. Origin and diversification of the clonogenic cell in multiple myeloma: lessons from the immunoglobulin repertoire. Leukemia 2000;14:1718-26.
27. Suarez F, Lortholary O, Hermine O, Lecuit M. Infection-associated lymphomas derived from marginal zone B cells: a model of antigendriven lymphoproliferation. Blood 2006;107:3034-44.
28. Prabhala RH, Neri P, Bae JE, Tassone P, Shammas MA, Allam CK, Daley JF, Chauhan D, Blanchard E, Thatte HS, Anderson KC, Munshi NC. Dysfunctional T regulatory cells in multiple myeloma. Blood 2006;107:301-4.