Systematic search and molecular characterization of the antigenic targets of myeloma immunoglobulins: A monoclonal IgA from a female patient targeting sperm-specific cylicin II

Cancer Immunity

Volumn 1, Issue , 2001, Pages 1-8

  Xie, Xiaoxun ^a   Schmits, Rudolf ^a   Renner, Christoph ^a   Preuß, Dieter ^a   Kubuschok, Boris ^a   Pfreundschuh, Michael ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Antigenic targets; Cylicin II; Human; mRNA; Multiple myeloma; Paraproteins; SEREX; Tissue distribution

Indexed keywords

CYLICIN II; DNA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; PARAPROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; ARTICLE; B CELL LEUKEMIA; BLADDER CARCINOMA; BREAST CANCER; CANCER IMMUNOLOGY; CHEMICAL ANALYSIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA LIBRARY; ENDOMETRIUM CARCINOMA; FEMALE; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CARCINOMA; LEIOMYOMA; LUNG CANCER; LYMPHOMA; MALE; MELANOMA; MENINGIOMA; MOLECULAR CLONING; MYELOMA; NEUROBLASTOMA; OVARY CANCER; PANCREAS CARCINOMA; PROSTATE CANCER; SEROLOGY; STOMACH CANCER;

EID: 3142653145     PISSN: 14249634     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Jäck H-M, Beck-Engeser G, Lee G, Wofsy D, Wabl M. Tumorigenesis mediated by an antigen receptor. Proc Natl Acad Sci USA 1992;89: 8482-6. (PMID: 1528851)
2. Friedman DF, Cho EA, Goldman J, Carmack CE, Besa EC, Hardy RR, Silberstine LE. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. J Exp Med 1991;174: 525-37. (PMID: 1908508)
3. Seligmann M, Brouet JC. Antibody activity of human myeloma globulins. Sem Hematol 1973;10: 163-77. (PMID: 4121353)
4. Colwell NS, Tollefsen DM, Blinder MA. Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder. Br J Haematol 1997;97: 219-26. (PMID: 9136969)
5. Konrad RJ, Kricka LJ, Goodman DBP, Goldman J, Silberstein LE. Brief report: Myeloma-associated paraprotein directed against the HIV-1 p24 antigen in an HIV-1 seropositive patient. New Engl J Med 1993;328: 1817-9. (PMID: 8502271)
6. Seligmann M, Danon F, Basch A, Bernard J: IgG myeloma cryoglobulin with antistreptolysin activity. Nature 1968;220: 711-3. (PMID: 5688148)
7. Sahin U, Türeci Ö, Schmitt H, Cochlovius B, Stenner F, Schobert I, Luo G, Schmits R, Pfreundschuh M: Human neoplasms elicit multiple immune responses in the autologous host. Proc Natl Acad Sci USA 1995;92: 11810-3. (PMID: 8524854)
8. Hess H, Heid H, Zimbelmann R, Franke WW. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. Exp Cell Res 1995;218: 174-82. (PMID: 7737358)
9. Adams RLP, Burdon RH, Fulton J. Methylation of satellite DNA. Biochem Biophys Res Communications 1983;113: 695-702. (PMID: 6870881)
10. Chen YT, Scanlan MJ, Sahin U, Türeci Ö, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci USA 1997;94: 1914-8. (PMID: 9050879)
11. Potter M: Myeloma proteins (M-components) with antibody-like activity. N Engl J Med 1971;284: 831-8. (PMID: 4101199)
12. Mansa B, Kjems E: Extremely high content of anti-alpha-staphylolysin in serum samples from a patient with multiple myeloma. Acta Pathol Microbiol Scand 1965; 65: 303-10. (PMID: 5867499)
13. Seligmann M, Sassy C, Chevalier A. A human myeloma protein with anti-alpha2-macroglobulin antibody activity. J Immunol 1973;110: 85-90. (PMID: 4631075)
14. Berenson JR. Etiology of multiple myeloma: What's new? Semin Oncol 1999;26 (5 Suppl 13): 2-9. (PMID: 10528889)
15. Türeci Ö, Chen Y-T, Sahin U, Güre AO, Zwick C, Villena C, Tsang S, Seitz G, Old LJ, Pfreundschuh M. Expression of SSX genes in human tumors. Int J Cancer 1998;77: 19-23. (PMID: 9639388)