Role of teichoic acid choline moieties in the virulence of Streptococcus pneumoniae

Infection and Immunity

Volumn 77, Issue 7, 2009, Pages 2824-2831

  Gehre, Florian ^a   Spisek, Radek ^a,b   Kharat, Arun S ^a,c   Matthews, Phillip ^a   Kukreja, Anjli ^a   Anthony, Robert M ^a   Dhodapkar, Madhav V ^a,d   Vollmer, Waldemar ^e   Tomasz, Alexander ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^c DR BABASAHEB AMBEDKAR MARATHWADA UNIVERSITY   (India)

^d YALE UNIVERSITY   (United States)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; TEICHOIC ACID; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BLOOD FLOW; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN SECRETION; SPLEEN CELL; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; CELL WALL; CHOLINE; CYTOKINES; DENDRITIC CELLS; FEMALE; MALE; MICE; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; SURVIVAL ANALYSIS; TEICHOIC ACIDS; VIRULENCE; VIRULENCE FACTORS;

EID: 67650045747     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00986-08     Document Type: Article

References (20)

1. Briles, E. B., and A. Tomasz. 1973. Pneumococcal Forssman antigen. A choline-containing lipoteichoic acid. J. Biol. Chem. 248:6394-6397.
2. Brundish, D. E., and J. Baddiley. 1968. Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate. Biochem. J. 110:573-582.
3. Colino, J., Y. Shen, and C. M. Snapper. 2002. Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms. J. Exp. Med. 195:1-13.
4. Damjanovic, M., A. S. Kharat, A. Eberhardt, A. Tomasz, and W. Vollmer. 2007. The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae. J. Bacteriol. 189:7105-7111.
5. Dhodapkar, K. M., J. L. Kaufman, M. Ehlers, D. K. Banerjee, E. Bonvini, S. Koenig, R. M. Steinman, J. V. Ravetch, and M. V. Dhodapkar. 2005. Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc. Natl. Acad. Sci. USA 102:2910-2915.
6. Draing, C., M. Pfitzenmaier, S. Zummo, G. Mancuso, A. Geyer, T. Hartung, and S. von Aulock. 2006. Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae. J. Biol. Chem. 281:33849-33859.
7. Fischer, W., T. Behr, R. Hartmann, J. Peter-Katalinic, and H. Egge. 1993. Teichoic acid and lipoteichoic acid of Streptococcus pneumoniae possess identical chain structures. A reinvestigation of teichoid acid (C polysaccharide). Eur. J. Biochem. 215:851-857.
8. Gehre, F., S. L. Leib, D. Grandgirard, J. Kummer, A. Buhlmann, F. Simon, R. Gaumann, A. S. Kharat, M. G. Tauber, and A. Tomasz. 2007. Essential role of choline for pneumococcal virlence in an experimental model of meningitis. J. Intern. Med. 264:143-154.
9. Horne, D. S., and A. Tomasz. 1993. Possible role of a choline-containing teichoic acid in the maintenance of normal cell shape and physiology in Streptococcus oralis. J. Bacteriol. 175:1717-1722.
10. Kharat, A. S., D. Denapaite, F. Gehre, R. Bruckner, W. Vollmer, R. Hakenbeck, and A. Tomasz. 2008. Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence. J. Bacteriol. 190:5907-5914.
11. Kharat, A. S., and A. Tomasz. 2006. Drastic reduction in the virulence of Streptococcus pneumoniae expressing type 2 capsular polysaccharide but lacking choline residues in the cell wall. Mol. Microbiol. 60:93-107.
12. Majcherczyk, P. A., and P. Moreillon. 2004. Inflammation and host defense, p. 183-200. In E. Tuomanen (ed.), The pneumococcus. ASM Press, Washington DC.
13. Nesin, M., M. Ramirez, and A. Tomasz. 1998. Capsular transformation of a multidrug-resistant Streptococcus pneumoniae in vivo. J. Infect. Dis. 177:707-713.
14. Rane, L., and Y. Subbarow. 1940. Nutritional requirements of the pneumococcus. I. Growth factors for types I, II, V, VII, VIII. J. Bacteriol. 40:695-704.
15. Schroder, N. W., S. Morath, C. Alexander, L. Hamann, T. Hartung, U. Zahringer, U. B. Gobel, J. R. Weber, and R. R. Schumann. 2003. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278:15587-15594.
16. Schwandner, R., R. Dziarski, H. Wesche, M. Rothe, and C. J. Kirschning. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274:17406-17409.
17. Severin, A., D. Horne, and A. Tomasz. 1997. Autolysis and cell wall degradation in a choline-independent strain of Streptococcus pneumoniae. Microb. Drug Resist. 3:391-400.
18. Tomasz, A. 1967. Choline in the cell wall of a bacterium: novel type of polymer-linked choline in Pneumococcus. Science 157:694-697.
19. Tomasz, A. 1964. Progr. 64th Gen. Meet. Am. Soc. Microbiol., abstr. G87. American Society for Microbiology, Washington, DC.
20. Weber, J. R., P. Moreillon, and E. I. Tuomanen. 2003. Innate sensors for gram-positive bacteria. Curr. Opin. Immunol. 15:408-415.