Angiogenesis and vascular endothelial growth factor-/receptor expression in myeloproliferative neoplasms: Correlation with clinical parameters and JAK2-V617F mutational status

British Journal of Haematology

Volumn 146, Issue 2, 2009, Pages 150-157

  Medinger, Michael ^b   Skoda, Radek ^b   Gratwohl, Alois ^b   Theocharides, Alexandre ^b   Buser, Andreas ^b   Heim, Dominik ^b   Dirnhofer, Stephan ^a   Tichelli, André ^b   Tzankov, Alexandar ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Angiogenesis; JAK2 V617F mutation; Microvessel density; Myeloproliferative neoplasms; Vascular endothelial growth factor; VEGF receptors

Indexed keywords

JANUS KINASE 2; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BONE MARROW; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; MYELOID METAPLASIA; MYELOPROLIFERATIVE DISORDER; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTOPENIA;

BONE MARROW; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; JANUS KINASE 2; MALE; MICROVESSELS; MIDDLE AGED; MUTATION; MYELOPROLIFERATIVE DISORDERS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67649982789     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07726.x     Document Type: Article

References (33)

1. Benouchan, M. Colombo, B.M. (2005) Anti-angiogenic strategies for cancer therapy. International Journal of Oncology, 27, 563 571.
2. Boveri, E., Passamonti, F., Rumi, E., Pietra, D., Elena, C., Arcaini, L., Pascutto, C., Castello, A., Cazzola, M., Magrini, U. Lazzarino, M. (2008) Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations. British Journal of Haematology, 140, 162 168. (Pubitemid 350265037)
3. Dias, S., Hattori, K., Heissig, B., Zhu, Z., Wu, Y., Witte, L., Hicklin, D.J., Tateno, M., Bohlen, P., Moore, M.A. Rafii, S. (2001) Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proceedings of the National Academy of Sciences of the United States of America, 98, 10857 10862. (Pubitemid 32878709)
4. Dudley, A.C., Thomas, D., Best, J. Jenkins, A. (2005) A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia. The Biochemical Journal, 390, 427 436. (Pubitemid 41337104)
5. Ferrara, N., Gerber, H.P. LeCouter, J. (2003) The biology of VEGF and its receptors. Nature Medicine, 9, 669 676. (Pubitemid 36749215)
6. Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid, and other disease. Nature Medicine, 1, 27 31.
7. Fonsatti, E., Del Vecchio, L., Altomonte, M., Sigalotti, L., Nicotra, M.R., Coral, S., Natali, P.G. Maio, M. (2001) Endoglin: an accessory component of the TGFbeta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies. Journal of Cellular Physiology, 188, 1 7. (Pubitemid 32476491)
8. Gianelli, U., Vener, C., Raviele, P.R., Savi, F., Somalvico, F., Calori, R., Iurlo, A., Radaelli, F., Fermo, E., Bucciarelli, P., Bori, S., Coggi, G. Deliliers, G.L. (2007) VEGF expression correlates with microvessel density in Philadelphia chromosome-negative chronic myeloproliferative disorders. American Journal of Clinical Pathology, 128, 966 973.
9. Gille, H., Kowalski, J., Li, B., LeCouter, J., Moffat, B., Zioncheck, T.F., Pelletier, N. Ferrara, N. (2001) Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. The Journal of Biological Chemistry, 276, 3222 3230.
10. Karp, J.E., Gojo, I., Pili, R., Gocke, C.D., Greer, J., Guo, C., Qian, D., Morris, L., Tidwell, M., Chen, H. Zwiebel, J. (2004) Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab. Clinical Cancer Research, 10, 3577 3585. (Pubitemid 38697590)
11. Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S. Ferrara, N. (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature, 362, 841 844.
12. Kralovics, R., Passamonti, F., Buser, A.S., Teo, S.S., Tiedt, R., Passweg, J.R., Tichelli, A., Cazzola, M. Skoda, R.C. (2005) A gain-of-function mutation of JAK2 in myeloproliferative isorders. New England Journal of Medicine, 352, 1779 1790. (Pubitemid 40570926)
13. Kralovics, R., Teo, S.S., Li, S., Theocharides, A., Buser, A.S., Tichelli, A. Skoda, R.C. (2006) Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood, 108, 1377 1380. (Pubitemid 44232040)
14. Kvasnicka, H.M. Thiele, J. (2004) Bone marrow angiogenesis: methods of quantification and changes evolving in chronic myeloproliferative disorders. Histology and Histopathology, 19, 1245 1260. (Pubitemid 39386784)
15. Lundberg, L.G., Lerner, R., Sundelin, P., Rogers, R., Folkman, J. Palmblad, J. (2000) Bone marrow in polycythemia vera, chronic myelocytic leukemia, and myelofibrosis has an increased vascularity. American Journal of Pathology, 157, 15 19. (Pubitemid 30641719)
16. Martyré, M.C., Romquin, N., Le Bousse-Kerdiles, M.C., Chevillard, S., Benyahia, B., Dupriez, B., Demory, J.L. Bauters, F. (1994) Transforming growth-factor-beta and megacaryocytes in the pathogenesis of idiopathic myelofibrosis. British Journal of Haematology, 88, 9 16. (Pubitemid 24293846)
17. Mesa, R.A., Hanson, C.A., Rajkumar, S.V., Schroeder, G. Tefferi, A. (2000) Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia. Blood, 96, 3374 3380. (Pubitemid 30836314)
18. Miller, D.W., Graulich, W., Karges, B., Stahl, S., Ernst, M., Ramaswamy, A., Sedlacek, H.H., Müller, R. Adamkiewicz, J. (1999) Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. International Journal of Cancer, 81, 568 572. (Pubitemid 29203054)
19. Padró, T., Ruiz, S., Bieker, R., Bürger, H., Steins, M., Kienast, J., Büchner, T., Berdel, W.E. Mesters, R.M. (2000) Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood, 95, 2637 2644. (Pubitemid 30210544)
20. Panteli, K., Zagorianakou, N., Bai, M., Katsaraki, A., Agnantis, N.J. Bourantas, K. (2004) Angiogenesis in chronic myeloproliferative diseases detected by CD34 expression. European Journal of Haematology, 72, 410 415. (Pubitemid 38703532)
21. Perkins, N.J. Schisterman, E.F. (2006) The inconsistency of "optimal" cutpoints obtained using two criteria based on the receiver operating characteristic curve. American Journal of Epidemiology, 163, 670 675.
22. Ponzoni, M., Savage, D.G., Ferreri, A.J., Pruneri, G., Viale, G., Servida, P., Bertolini, F. Orazi, A. (2004) Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining. Modern Pathology, 17, 1513 1520. (Pubitemid 39627078)
23. Rajkumar, S.V., Mesa, R.A., Fonseca, R., Schroeder, G., Plevak, M.F., Dispenzieri, A., Lacy, M.Q., Lust, J.A., Witzig, T.E., Gertz, M.A., Kyle, R.A., Russell, S.J. Greipp, P.R. (2002) Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis. Clinical Cancer Research, 8, 2210 2216. (Pubitemid 34753592)
24. Steurer, M., Zoller, H., Augustin, F., Fong, D., Heiss, S., Strasser-Weippl, K., Gastl, G. Tzankov, A. (2007) Increased angiogenesis in chronic idiopathic myelofibrosis: vascular endothelial growth factor as a prominent angiogenic factor. Human Pathology, 38, 1057 1064. (Pubitemid 46899150)
25. Stifter, G., Heiss, S., Gastl, G., Tzankov, A. Stauder, R. (2005) Over-expression of tumor necrosis factor-alpha in bone marrow biopsies from patients with myelodysplastic syndromes: relationship to anemia and prognosis. European Journal of Haematology, 75, 485 491. (Pubitemid 41687782)
26. Thiele, J., Kvasnicka, H.M., Facchetti, F., Franco, V., van der Walt, J. Orazi, A. (2005) European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica, 90, 1128 1132. (Pubitemid 41323513)
27. Tzankov, A., Heiss, S., Ebner, S., Sterlacci, W., Schaefer, G., Augustin, F., Fiegl, M. Dirnhofer, S. (2007) Angiogenesis in nodal B cell lymphomas: a high throughput study. Journal of Clinical Pathology, 60, 476 482. (Pubitemid 46867154)
28. Tzankov, A., Meier, C., Hirschmann, P., Went, P., Pileri, S.A. Dirnhofer, S. (2008) Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica, 93, 193 200.
29. Warrington, K., Hillarby, M.C., Li, C., Letarte, M. Kumar, S. (2005) Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells. Anticancer Research, 25, 1851 1864. (Pubitemid 40904577)
30. Wolowiec, D., Wozniak, Z., Potoczek, S., Ganczarski, G., Wrobel, T., Kuliczkowski, K., Frydecka, I. Jeleń, M. (2004) Bone marrow angiogenesis and proliferation in B-cell chronic lymphocytic leukemia. Analytical and Quantitative Cytology and Histology, 26, 263 270. (Pubitemid 39458645)
31. Wrobel, T., Mazur, G., Surowiak, P., Wolowiec, D., Jelen, M. Kuliczkowsky, K. (2003) Increased expression of vascular endothelial growth factor (VEGF) in bone marrow of patients with myeloproliferative disorders (MPD). Pathology Oncology Research, 9, 170 173. (Pubitemid 37429496)
32. Zetterberg, E., Lundberg, L.G. Palmblad, J. (2004) Characterization of blood vessels in bone marrow from patients with chronic myeloid leukemia and polycythemia vera. Scandinavian Journal of Clinical and Laboratory Investigation, 64, 641 647. (Pubitemid 39425303)
33. Zhu, K., Amin, M.A., Zha, Y., Harlow, L.A. Koch, A.E. (2005) Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesis. Blood, 105, 2343 2349. (Pubitemid 40387029)