Discovery of β-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4201-4203

  Nordhoff, Sonja ^a   Cerezo Gálvez, Silvia ^a   Deppe, Holger ^a   Hill, Oliver ^a   López Canet, Meritxell ^a   Rummey, Christian ^a   Thiemann, Meinolf ^a   Matassa, Victor G ^a   Edwards, Paul J ^a   Feurer, Achim ^a  

^a Santhera Pharmaceuticals   (Switzerland)

Author keywords

Dipeptidyl peptidase IV; DPP 4; GLP 1; Glucagon like peptide 1; Type 2 diabetes

Indexed keywords

3 AMINO 4 PHENYLBUTYRIC ACID; AMIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; PHENYLALANINE; PYRROLIDIN 2 YLMETHYL AMIDE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; LIPOPHILICITY; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDES; AMINOBUTYRIC ACIDS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DESIGN; GLUCAGON-LIKE PEPTIDE 1; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 67649922154     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.109     Document Type: Article

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