Study of aerobic granulocyte functional activity in the presence of a radiosensitizer (metronidazole)

Eastern Mediterranean Health Journal

Volumn 15, Issue 1, 2009, Pages 224-229

  Al Krawi, E A A ^a   Al Hashimi, A H M ^a  

^a UNIVERSITY OF BASRAH   (Iraq)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; LUMINOL; METRONIDAZOLE; NITROBLUE TETRAZOLIUM; RADIOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; ANTIINFECTIVE AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CELL FUNCTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; DOSE RESPONSE; GRANULOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; POLYMORPHONUCLEAR CELL; AEROBIC METABOLISM; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; MIDDLE AGED; NEUTROPHIL; OXIDATIVE STRESS; PHAGOCYTOSIS; PHYSIOLOGY;

ADULT; AEROBIOSIS; ANTI-INFECTIVE AGENTS; CHEMILUMINESCENT MEASUREMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; HUMANS; INDICATORS AND REAGENTS; LUMINOL; METRONIDAZOLE; MIDDLE AGED; NADP; NEUTROPHILS; NITROBLUE TETRAZOLIUM; OXIDATIVE STRESS; PHAGOCYTOSIS; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES;

EID: 67649868311     PISSN: 10203397     EISSN: None     Source Type: Journal    
DOI: 10.26719/2009.15.1.224     Document Type: Article

References (21)

1. Robert AF, ed. Free radicals and cancer. New York, Marcel Dakker, 1982:325.
2. Stratford IJ. Bioreductive drugs in cancer therapy. In: Denkamp J, Hirst DG, Eds. Radiation science: of molecules, mice and men. London, British Institute of Radiology, 1992:128-36 (British journal of radiology supplement 24).
3. Zharkov VV et al. [The immediate results of the use of isometronidazole in the combination therapy of patients with lung cancer]. Meditsinskaia radiologiia, 1991, 36(7):18-20 [In Russian].
4. Wong KH, Maezawa H, Urano M. Comparative study of thermoradiosensitization by misonidazole and metronidazole in vivo: antitumour effect and pharmacokinetics. International journal of hyperthermia, 1992, 8(5):645-58.
5. Acharya DK. Role of metronidazole in radiation therapy (a review of 717 cancer cases). Indian journal of medical sciences, 1994, 48(5):111-6.
6. Galecki J et al. [Comparison of the effectiveness of different methods of irradiation using metronidazole as a radiation-sensitizing agent in patients with laryngeal cancer. Controlled clinical studies]. Nowotwory, 1989, 39(2):111-5 [In Polish].
7. Shchepetkin IA. [Metronidazole effect on active oxygen production by human blood neutrophils]. Antibiotiki i khimioterapiia, 1997, 42(8):38-41 [In Russian].
8. Akamatsu H, Horio T. The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. Dermatology, 1998, 196(1):82-5.
9. Brown JM. The hypoxic cell: a target for selective cancer therapy - eighteenth Bruce F. Cain Memorial Award lecture Cancer research, 1999, 59:5863-70.
10. Overgaard J. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncology research, 1994, 6:509-18.
11. Rajendran JG et al. Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography imaging. Clinical cancer research, 2004, 10(7):2245-52.
12. Rogers MAJ, Powers EL, eds. Oxygen and oxyradicals in chemistry and biology. New York, Academic Press, 1981:349-54.
13. Googman SI et al. Molecular cloning and expression of a cDNA encoding human electron transfer flavoprotein-ubiquinone oxidoreductase. European journal of biochemistry, 1994, 219:277-86.
14. Gordan JM, Walker CB. Current status systemic antibiotic usage in destruction of periodontal disease. Journal of periodontology, 1993, 64(Suppl. 1):760-71.
15. Eick S et al. Clindamycin promotes phagocytosis and intracellular killing of periodontopathogenic bacteria by crevicular granulocytes: an in vitro study. Journal of antimicrobial chemotherapy, 2000, 46:583-8.
16. Van Vlem B et al. Immunomodulating effect of antibiotics: Literature review. Infection, 1996, 24:275-91.
17. Metcalf JA et al. Laboratory manual of neutrophil function. New York, Raven Press, 1986:100-5.
18. Al Hashimi AH, Al Krawi EA. A study of the redox and kinetic functional activity of respiratory bursts in normal granulocytes of human whole blood by means of lucigenin and luminal dependent CL. Basrah University Medical Journal, 2000, 18(2):22-5.
19. Shchepetkin IA, Iur'ev SI. [Effect of metronidazole on luminol dependent chemiluminescence of neutrophils in whole blood of patients with chlamydial infection]. Antibiotiki i khimioterapiia, 1998, 43(3):31-6 [In Russian].
20. Davies NM, Jamali F. Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers. Human & experimental toxicology, 1997, 16:345-9.
21. Leite AZ et al Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism. Gut, 2001, 48:163-7.