A Gating Model for the Archeal Voltage-Dependent K+ Channel KvAP in DPhPC and POPE:POPG Decane Lipid Bilayers

Journal of Molecular Biology

Volumn 390, Issue 5, 2009, Pages 902-912

  Schmidt, Daniel ^a   Cross, Samuel R ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

channel inactivation; Kv channel; lipid membrane; voltage sensor toxin; voltage dependent gating

Indexed keywords

PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; POTASSIUM CHANNEL KVAP; SHAKER POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARCHAEBACTERIUM; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYPERPOLARIZATION; LIPID COMPOSITION; MEMBRANE DEPOLARIZATION; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION;

EUKARYOTA;

EID: 67649867931     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.05.062     Document Type: Article

References (28)

1. Hodgkin A.L., and Huxley A.F. Resting and action potentials in single nerve fibres. J. Physiol. (London) 104 (1945) 176-195
2. Hodgkin A.L., and Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (London) 117 (1952) 500-544
3. Hoshi T., Zagotta W.N., and Aldrich R.W. Shaker potassium channel gating: I. Transitions near the open state. J. Gen. Physiol. 103 (1994) 249-278
4. Schoppa N.E., and Sigworth F.J. Activation of Shaker potassium channels: I. Characterization of voltage-dependent transitions. J. Gen. Physiol. 111 (1998) 271-294
5. Zagotta W.N., Hoshi T., and Aldrich R.W. Shaker potassium channel gating: III. Evaluation of kinetic models for activation. J. Gen. Physiol. 103 (1994) 321-362
6. Zagotta W.N., Hoshi T., Dittman J., and Aldrich R.W. Shaker potassium channel gating: II. Transitions in the activation pathway. J. Gen. Physiol. 103 (1994) 279-319
7. Hoshi T., Zagotta W., and Aldrich R. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (New York, NY) 250 (1990) 533-538
8. + channels: effects of alterations in the carboxy-terminal region. Neuron 7 (1991) 547-556
9. + channel. Nature 423 (2003) 33-41
10. + channel. Nature 422 (2003) 180-185
11. Ruta V., and Mackinnon R. Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry 43 (2004) 10071-10079
12. Schmidt D., Jiang Q.X., and Mackinnon R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature 444 (2006) 775-779
13. Lee S.Y., and Mackinnon R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430 (2004) 232-235
14. Milescu M., Vobecky J., Roh S.H., Kim S.H., Jung H.J., Kim J.I., and Swartz K.J. Tarantula toxins interact with voltage sensors within lipid membranes. J. Gen. Physiol. 130 (2007) 497-511
15. + channels. Neuron 18 (1997) 675-682
16. + channel through multiple binding sites. Neuron 18 (1997) 665-673
17. Aldrich R.W. Inactivation of voltage-gated delayed potassium current in molluscan neurons. A kinetic model. Biophys. J. 36 (1981) 519-532
18. Aldrich R.W., Getting P.A., and Thompson S.H. Inactivation of delayed outward current in molluscan neurone somata. J. Physiol. (London) 291 (1979) 507-530
19. Marom S., and Abbott L.F. Modeling state-dependent inactivation of membrane currents. Biophys. J. 67 (1994) 515-520
20. Marom S., and Levitan I.B. State-dependent inactivation of the Kv3 potassium channel. Biophys. J. 67 (1994) 579-589
21. Klemic K.G., Shieh C.C., Kirsch G.E., and Jones S.W. Inactivation of Kv2.1 potassium channels. Biophys. J. 74 (1998) 1779-1789
22. + channel allows inactivation to be modulated by metal binding. Biophys. J. 66 (1994) 1068-1075
23. +]: a tale of two inactivation mechanisms. Neuron 15 (1995) 951-960
24. Klemic K.G., Kirsch G.E., and Jones S.W. U-type inactivation of Kv3.1 and Shaker potassium channels. Biophys. J. 81 (2001) 814-826
25. Armstrong N., Jasti J., Beich-Frandsen M., and Gouaux E. Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Cell 127 (2006) 85-97
26. + channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc. Natl Acad. Sci. USA 105 (2008) 19276-19281
27. Tabarean I.V., and Morris C.E. Membrane stretch accelerates activation and slow inactivation in Shaker channels with S3-S4 linker deletions. Biophys. J. 82 (2002) 2982-2994
28. Miller C. Ion Channel Reconstitution (1986), Plenum Press, New York