Engraftment of bone marrow-derived stem cells to the lung in a model of acute respiratory infection by Pseudomonas aeruginosa

Molecular Therapy

Volumn 17, Issue 7, 2009, Pages 1257-1265

  Rejman, Joanna ^a   Colombo, Carla ^b   Conese, Massimo ^a,c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF FOGGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELL SUSPENSION; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; COLONY FORMING UNIT; CONTROLLED STUDY; CYSTIC FIBROSIS; ENGRAFTMENT; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PURIFICATION; RESPIRATORY TRACT INFECTION; Y CHROMOSOME;

BACTERIA (MICROORGANISMS); MUS; PSEUDOMONAS AERUGINOSA;

ANIMALS; BONE MARROW CELLS; BRONCHOALVEOLAR LAVAGE FLUID; LUNG; MICE; MICE, INBRED C57BL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS; STEM CELLS; TISSUE THERAPY;

EID: 67649861097     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2009.96     Document Type: Article

References (49)

1. Dominici, M, Le Blanc, K, Mueller, I, Slaper-Cortenbach, I, Marini, F, Krause, D et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317.
2. Piro, D, Lepore, S, Maffione, AB and Conese, M (2008). Bone marrow-derived stem cells: Homing and rescue of injury in the lung. In: Neumann, KB (ed.). Hematopoietic Stem Cell Transplantation Research Advances. Nova Science Publishers: Hauppauge, NY, pp. 15-43.
3. Krause, DS, Theise, ND, Collector, MI, Henegariu, O, Hwang, S, Gardner, R et al. (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369-377.
4. Abe, S, Boyer, C, Liu, X, Wen, FQ, Kobayashi, T, Fang, Q et al. (2004). Cells derived from the circulation contribute to the repair of lung injury. Am J Respir Crit Care Med 170: 1158-1163.
5. Theise, ND, Henegariu, O, Grove, J, Jagirdar, J, Kao, PN, Crawford, JM et al. (2002). Radiation pneumonitis in mice: A sever injury model for pneumocyte engraftment from bone marrow. Exp Hematol 30: 1333-1338.
6. Grove, JE, Lutzko, C, Priller, J, Henegariu, O, Theise, ND, Kohn, DB et al. (2002). Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. Am J Respir Cell Mol Biol 27 645-651.
7. Serikov, VB, Popov, B, Mikhailov, VM, Gupta, N and Matthay, MA (2007). Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken) 290: 1033-1045.
8. Kleeberger, W, Versmold, A, Rothämel, T, Glöckner, S, Bredt, M, Haverich, A et al. (2003). Increased chimerism of bronchial and alveolar epithelium in human lung allografts undergoing chronic injury. Am J Pathol 162: 1487-1494.
9. Spencer, H, Rampling, D, Aurora, P, Bonnet, D, Hart, SL and Jaffé, A (2005). Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation. Thorax 60: 60-62.
10. Worlitzsch, D, Tarran, R, Ulrich, M, Schwab, U, Cekici, A, Meyer, KC et al. (2002). Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 109: 317-325.
11. Singh, PK, Schaefer, AL, Parsek, MR, Moninger, TO, Welsh, MJ and Greenberg, EP (2000). Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407 762-764.
12. Ratjen, F and Döring, G (2003). Cystic fibrosis. Lancet 361 681-689.
13. Kotton, DN, Ma, BY, Cardoso, WV, Sanderson, EA, Summer, RS, Williams, MC et al. (2001). Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 128: 5181-5188.
14. MacPherson, H, Keir, P, Webb, S, Samuel, K, Boyle, S, Bickmore, W et al. (2005). Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivo. J Cell Sci 118(Pt 11): 2441-2450.
15. MacPherson, H, Keir, PA, Edwards, CJ, Webb, S and Dorin, JR (2006). Following damage, the majority of bone marrow-derived airway cells express an epithelial marker. Respir Res 7: 145.
16. Ortiz, LA, Dutreil, M, Fattman, C, Pandey, AC, Torres, G, Go, K et al. (2007). Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 104: 11002-11007.
17. Ortiz, LA, Gambelli, F, McBride, C, Gaupp, D, Baddoo, M, Kaminski, N et al. (2003). Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 100: 8407-8411.
18. Rojas, M, Xu, J, Woods, CR, Mora, AL, Spears, W, Roman, J et al. (2005). Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33: 145-152.
19. Xu, J, Woods, CR, Mora, AL, Joodi, R, Brigham, KL, Iyer, S et al. (2007). Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol 293: L131-L141.
20. Beckett, T, Loi, R, Prenovitz, R, Poynter, M, Goncz, KK, Suratt, BT et al. (2005). Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrow. Mol Ther 12: 680-686.
21. Herzog, EL, Van Arnam, J, Hu, B and Krause, DS (2006). Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells 24: 1986-1992.
22. Aliotta, JM, Keaney, P, Passero, M, Dooner, MS, Pimentel, J, Greer, D et al. (2006). Bone marrow production of lung cells: The impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype. Exp Hematol 34: 230-241.
23. Rejman, J, Di Gioia, S, Bragonzi, A and Conese, M (2007). Pseudomonas aeruginosa infection destroys the barrier function of lung epithelium and enhances polyplexmediated transfection. Hum Gene Ther 18 642-652.
24. Harris, RG, Herzog, EL, Bruscia, EM, Grove, JE, Van Arnam, JS and Krause, DS (2004). Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 305: 90-93.
25. Doring, G, Bellon, G and Knight, R (2000). Immunology of cystic fibrosis. In: Hodson, ME, Geddes, DM (eds.). Cystic Fibrosis. Arnold: London, pp. 109-140.
26. Conese, M, Copreni, E, Piro, D and Rejman, J (2007). Gene and cell therapy for the treatment of cystic fibrosis. Adv Gene Mol Cell Ther 1: 99-119.
27. Mei, SH, McCarter, SD, Deng, Y, Parker, CH, Liles, WC and Stewart, DJ (2007). Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med 4: E269.
28. Jiang, Y, Jahagirdar, BN, Reinhardt, RL, Schwartz, RE, Keene, CD, Ortiz-Gonzalez, XR et al. (2002). Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49.
29. Kotton, DN, Fabian, AJ and Mulligan, RC (2005). Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol 33 328-334.
30. Gupta, N, Su, X, Popov, B, Lee, JW, Serikov, V and Matthay, MA (2007). Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179: 1855-1863.
31. Yamada, M, Kubo, H, Kobayashi, S, Ishizawa, K, Numasaki, M, Ueda, S et al. (2004). Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 172: 1266-1272.
32. Ishizawa, K, Kubo, H, Yamada, M, Kobayashi, S, Numasaki, M, Ueda, S et al. (2004). Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema. FEBS Lett 556: 249-252.
33. Murakami, S, Nagaya, N, Itoh, T, Iwase, T, Fujisato, T, Nishioka, K et al. (2005). Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice. Am J Respir Crit Care Med 172: 581-589.
34. Wong, AP, Dutly, AE, Sacher, A, Lee, H, Hwang, DM, Liu, M et al. (2007). Targeted cell replacement with bone marrow cells for airway epithelial regeneration. Am J Physiol Lung Cell Mol Physiol 293 L740-L752.
35. Baber, SR, Deng, W, Master, RG, Bunnell, BA, Taylor, BK, Murthy, SN et al. (2007). Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am J Physiol Heart Circ Physiol 292: H1120-H1128.
36. Wong, AP, Keating, A, Lu, WY, Duchesneau, P, Wang, X, Sacher, A et al. (2009). Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. J Clin Invest 119: 336-348.
37. Loi, R, Beckett, T, Goncz, KK, Suratt, BT and Weiss, DJ (2006). Limited restoration of cystic fibrosis lung epithelium in vivo with adult marrow derived cells. Am J Respir Crit Care Med 173: 171-179.
38. Bruscia, EM, Price, JE, Cheng, EC, Weiner, S, Caputo, C, Ferreira, EC et al. (2006). Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proc Natl Acad Sci USA 103: 2965-2970.
39. Bruscia, EM, Ziegler, EC, Price, JE, Weiner, S, Egan, ME and Krause, DS (2006). Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells 24: 2299-2308.
40. Shivdasani, RA and Orkin, SH (1996). The transcriptional control of hematopoiesis. Blood 87: 4025-4039.
41. Sieweke, MH and Graf, T (1998). A transcription factor party during blood cell differentiation. Curr Opin Genet Dev 8: 545-551.
42. Gomperts, BN, Belperio, JA, Rao, PN, Randell, SH, Fishbein, MC, Burdick, MD et al. (2006). Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol 176 1916-1927.
43. Strieter, RM, Gomperts, BN and Keane, MP (2007). The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 117: 549-556.
44. Ishizawa, K, Kubo, H, Yamada, M, Kobayashi, S, Suzuki, T, Mizuno, S et al. (2004). Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells. Biochem Biophys Res Commun 324: 276-280.
45. Nervi, B, Link, DC and DiPersio, JF (2006). Cytokines and hematopoietic stem cell mobilization. J Cell Biochem 99: 690-705.
46. Piro, D, Rejman, J and Conese, M (2008). Stem cell therapy for cystic fibrosis: Current status and future prospects. Exp Rev Resp Med 2: 365-380.
47. Sueblinvong, V, Loi, R, Eisenhauer, PL, Bernstein, IM, Suratt, BT, Spees, JL et al. (2008). Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells. Am J Respir Crit Care Med 177: 701-711.
48. Stover, CK, Pham, XQ, Erwin, AL, Mizoguchi, SD, Warrener, P, Hickey, MJ et al. (2000). Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen. Nature 406: 959-964.
49. Trotman, W, Beckett, T, Goncz, KK, Beatty, BG and Weiss, DJ (2004). Dual Y chromosome painting and in situ cell-specific immunofluorescence staining in lung tissue: An improved method of identifying donor marrow cells in lung following bone marrow transplantation. Histochem Cell Biol 121: 73-79.