Signal separation and parameter estimation in noninvasive dual-tracer PET scans using reference-region approaches

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 7, 2009, Pages 1346-1357

  Joshi, Aniket D ^a,b   Koeppe, Robert A ^a   Fessler, Jeffrey A ^a,b   Kilbourn, Michael R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Carbon 11; Dual tracer; In vivo neuropharmacology; PET; Tracer kinetics

Indexed keywords

DIHYDROTETRABENAZINE C 11; FLUMAZENIL C 11; N METHYLPIPERIDINYLPROPIONATE C 11; TRACER; UNCLASSIFIED DRUG;

ADULT; ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; IMAGE PROCESSING; MATHEMATICAL ANALYSIS; NON INVASIVE MEASUREMENT; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STEADY STATE; TIME;

CARBON RADIOISOTOPES; FLUMAZENIL; HUMANS; METHODS; POSITRON-EMISSION TOMOGRAPHY; TETRABENAZINE;

EID: 67649845578     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.53     Document Type: Article

References (29)

1. Black NF, McJames S, Rust TC, Kadrmas DJ (2008) Evaluation of rapid dual-tracer (62)Cu-PTSM + (62)Cu-ATSM PET in dogs with spontaneously occurring tumors. Phys Med Biol 53:217-32
2. Comtat C, Kinihan PE, Defrise M, Michel C, Townsend DW (1998) Fast reconstruction of 3D data with accurate statistical modeling. IEEE Trans Nucl Sci 45:1083-9
3. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AK (1991) Compartmental analysis of diprenor-phine binding to opiate receptors in the rat in vivo and its comparison with equilibrium data in vitro. J Cereb Blood Flow Metab 11:1-9
4. Defrise M, Kinihan PE, Townsend DW, Michel C, Sibomana M, Newport DF (1997) Exact and approximate rebinning algorithms for 3-D PET data. IEEE Trans Med Imaging 16:145-58
5. Faraway J (2004) Weighted Least Squares. In: Linear Models with R. Chapman & Hall/CRC: Boca Raton, pp 92-4
6. Frey KA, Groom GN, Minoshima S, Koeppe RA, Kuhl DE (1993) True equilibrium quantification of human cerebral benzodiazepine receptors with the use of [11-C]flumazenil and positron tomography. J Nucl Med 34:108P
7. Herholz K, Lercher M, Wienhard K, Bauer B, Lenz O, Heiss WD (2001) PET measurement of cerebral acetylcholine esterase activity without blood sampling. Eur J Nucl Med 28:472-7
8. Holthoff VA, Koeppe RA, Frey KA, Paradise AH, Kuhl DE (1991) Differentiation of radioligand delivery and binding in the brain: validation of a two-compartment model for [11C]flumazenil. J Cereb Blood Flow Metab 11:745-52
9. Huang SC, Carson RE, Hoffman EJ, Kuhl DE, Phelps ME (1982) An investigation of a double-tracer technique for positron computerized tomography. J Nucl Med 23:816-22
10. Hudson HM, Larkin RS (1994) Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging 13:601-9
11. Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE (2007) Consensus nomenclature for in vivo imaging of rever-sibly binding radioligands. J Cereb Blood Flow Metab 27:1533-9
12. Joshi AD, Fessler JA, Koeppe RA (2008) Improving PET receptor binding estimates from Logan plots using principal component analysis. J Cereb Blood Flow Metab 28:852-65
13. Kadrmas DJ, Rust TC (2005) Feasibility of rapid multitracer PET tumor imaging. IEEE Trans Nucl Imag 52:1341-7
14. Koeppe RA, Frey KA, Kuhl DE, Kilbourn MR (1999a) Assessment of extrastriatal vesicular monoamine transporter binding site density using stereoisomers of [11C]dihydrotetrabenazine. J Cereb Blood Flow Metab 19:1376-84
15. Koeppe RA, Frey KA, Kume A, Albin R, Kilbourn MR, Kuhl DE (1997) Equilibrium versus compartmental analysis for assessment of the vesicular monoamine transporter using (+)-alpha-[11C]dihydrotetrabenazine (DTBZ) and positron emission tomography. J Cereb Blood Flow Metab 17:919-31
16. Koeppe RA, Frey KA, Snyder SE, Meyer P, Kilbourn MR, Kuhl DE (1999b) Kinetic modeling of N-[11C]methyl- piperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography trace for measurement of acetylcholinesterase activity in human brain. J Cereb Blood Flow Metab 19:1150-63
17. Koeppe RA, Frey KA, Vander Borght TM, Karlamangla A, Jewett DM, Lee LC, Kilbourn MR, Kuhl DE (1996) Kinetic evaluation of [11C]dihydrotetrabenazine by dynamic PET: measurement of vesicular monoamine transporter. J Cereb Blood Flow Metab 16:1288-99
18. Koeppe RA, Holthoff VA, Frey KA, Kilbourn MR, Kuhl DE (1991) Compartmental analysis of [11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 11:735-44
19. Koeppe RA, Joshi A, Frey K, Snyder SE, Kilbourn MR, Fessler J (2004) Dual-tracer PET studies without arterial sampling. NeuroImage 22:T115-6
20. 11C]tracer single-acquisition positron emission tomography studies. J Cereb Blood Flow Metab 21:1480-92
21. Lammertsma AA, Bench CJ, Hume SP, Osman S, Gunn K, Brooks DJ, Frackowiak RS (1996) Comparison of methods for analysis of clinical [11C]raclopride studies. J Cereb Blood Flow Metab 16:42-52
22. Lammertsma AA, Hume SP (1996) Simplified reference tissue model for PET receptor studies. Neuroimage 4:153-8
23. Logan J, Fowler JS, Volkow ND, Ding YS, Wang GJ, Alexoff DL (2001) A strategy for removing the bias in the graphical analysis method. J Cereb Blood Flow Metab 21:307-20
24. Minoshima S, Koeppe RA, Frey KA, Kuhl DE (1994) Anatomical standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med 35:1528-37
25. Minoshima S, Koeppe RA, Mintun MA, Berger KL, Taylor SS, Frey KA, Kuhl DE (1993) Automated detection of the intercommissural (AC-PC) line for stereotactic localization of functional brain images. J Nucl Med 34:322-9
26. Nagatsuka S, Fukushi K, Shinotoh H, Namba H, Iyo M, Tanaka N, Aotsuka A, Ota T, Tanada S, Irie T (2001) Kinetic analysis of [(11)C]MP4A using a high-radioactivity brain region that represents an integrated input function for measurement of cerebral acetylcholinester-ase activity without arterial blood sampling. J Cereb Blood Flow Metab 21:1354-66
27. Rust TC, DiBella EV, McGann CJ, Christian PE, Hoffman JM, Kadrmas DJ (2006) Rapid dual-injection single-scan 13N-ammonia PET for quantification of rest and stress myocardial blood flows. Phys Med Biol 51:5347-62
28. Rust TC, Kadrmas DJ (2006) Rapid dual-tracer PTSM+ATSM PET imaging of tumour blood flow and hypoxia: a simulation study. Phys Med Biol 51:61-75
29. Talairach J, Tournoux P (1988) Co-planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System - an Approach to Cerebral Imaging. New York, NY: Thieme Medical Publishers