Kinetic evaluation of [11C]dihydrotetrabenazine by dynamic PET: Measurement of vesicular monoamine transporter

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 6, 1996, Pages 1288-1299

  Koeppe, R A ^a   Frey, K A ^a   Vander Borght, T M ^a   Karlamangla, A ^a   Jewett, D M ^a   Lee, L C ^a   Kilbourn, M R ^a   Kuhl, D E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Monoamine vesicular transporter; Positron emission tomography; Tracer kinetics; VMAT2; 11C Dihydrotetrabenazine

Indexed keywords

CARBON 11; CARRIER PROTEIN; DIHYDROTETRABENAZINE; DRUG DERIVATIVE; MEMBRANE PROTEIN; NEUROPEPTIDE; SLC18A2 PROTEIN, HUMAN; TETRABENAZINE; VESICULAR AMINE TRANSPORTER; VESICULAR MONOAMINE TRANSPORTER;

ADULT; ARTICLE; BRAIN REGION; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; STATISTICAL ANALYSIS; SYNAPSE VESICLE; THEORY; BINDING SITE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; KINETICS; METABOLISM; RADIOASSAY; THEORETICAL MODEL; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; BINDING SITES; BIOLOGICAL TRANSPORT; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, THEORETICAL; NEUROPEPTIDES; RADIOLIGAND ASSAY; TETRABENAZINE; TOMOGRAPHY, EMISSION-COMPUTED; VESICULAR BIOGENIC AMINE TRANSPORT PROTEINS; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 0029661969     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199611000-00025     Document Type: Article

References (15)

1. Alpert NM, Eriksson L, Chang JY, Bergstrom M, Litton JE, Correia JA, Bohm C, Ackermann RH, Taveras JM (1984) Strategy for the measurement of regional cerebral blood flow using short-lived tracers and emission tomography. J Cereb Blood Flow Metab 4:28-34
2. 11C-nomifensine and positron emission tomography. Acta Neurol Scand 76:283-287
3. Bevington PR (1969) Data Reduction and Error Analysis for the Physical Sciences, New York, McGraw-Hill, pp 232-241
4. 11C]tetrabenazine to vesicular monoamine transporters in mouse brain. Life Sci 51:593-600
5. DeJesus OT, Holden JE, Endres CI, Shelton S, Nickles RJ (1995) Comparison of four [F-18]-labeled analogs as PET imaging agents for dopamine nerve terminals. J Nucl Med 36:253P
6. 11C] scopolamine and positron emission tomography. J Cereb Blood Flow Metab 12:147-154
7. Frey KA, Koeppe RA, Kilbourn MR, Vander Borght TM, Albin RL, Oilman S, Kuhl DE (1995) Reduction of presynaptic monoaminergic vesicles in the striata of Parkinsonian patients and in normal human aging. J Cereb Blood Flow Metab 15(1):S38
8. 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol 34:423-431
9. Garnett ES, Firnau G, Nahmias C (1983) Dopamine visualized in the basal ganglia of living man. Nature 305:137-138
10. Gjedde A, Reith J, Dyve S, Leger G, Guttman M, Diksic M, Evans A, Kuwabara H (1991) Dopa decarboxylase activity of the living human brain. Proc Natl Acad Sci USA 88:2721-2725
11. Gjedde A, Leger G, Cumming P, Yasuhara Y, Evans A, Guttman M, Kuwabara H (1993) Striatal L-DOPA-decarboxylase activity in Parkinson's disease in vivo: Implications for the regulation of dopamine synthesis. J Neurochem 61:1,538-1,541
12. 11C]dihydrotetrabenazine and PET. J Cereb Blood Flow Metab 15(1):S752
13. 3H-GBR-12,935 are differentially regulated by chronic cocaine self-administration. J Neurosci 14:2,966-2,979
14. Wilson JM, Kish SJ (1996) The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat. J Neurosci 16:3,507-3,510
15. Zhu MY, Juorio AC, Paterson IA, Boulton AA (1992) Regulation of aromatic L-amino acid decarboxylase by dopamine receptors in the rat brain. J Neurochem 58:636-64