Functional, metabolic, and morphological aspects of continuous, normothermic heart preservation: Effects of different preparation and perfusion techniques

Tissue Engineering - Part C: Methods

Volumn 15, Issue 2, 2009, Pages 275-283

  Garbade, Jens ^a   Krautz, Christian ^a   Aupperle, Heike ^a   Ullmann, Cris ^a   Lehmann, Sven ^a   Kempfert, Jörg ^a   Borger, Michael A ^a   Dhein, Stefan ^a   Gummert, Jan F ^b   Mohr, Friedrich Wilhelm ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOPSY; BLOOD; HARVESTING; MERCURY (METAL);

BEATING HEART; BLOOD PERFUSION; CARDIOPLEGIA; CIRCULATING PRESSURE; CONSTANT PRESSURES; HYPOTHERMIC; INTRACELLULAR ATP; LANGENDORFF; LEFT VENTRICULAR; MORPHOLOGICAL ASPECTS; PERFUSED HEARTS; PREPARATION TECHNIQUE; PRESERVATION STRATEGIES; REPERFUSION; TIME POINTS;

BLOOD PRESSURE;

ADENOSINE TRIPHOSPHATE; HTK SOLUTION;

ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CARDIOPLEGIA; CONTINUOUS NORMOTHERMIC HEART PERFUSION; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; EXPLANT; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PERFUSION; HEART PRESERVATION; ISOLATED HEART; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; PROTEIN CONTENT; SWINE;

SUIDAE;

EID: 67649845519     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2008.0475     Document Type: Article

References (27)

1. Bourge, R.C., Naftel, D.C., Costanzo-Nordin, M.R. Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. The Transplant Cardiologists Research Database Group. J Heart Lung Transplant 12, 549, 1993.
2. Hosenpud, J.D., Bennett, L.E., Keck, B.M., Boucek, M.M., Novick, R.J. The Registry of the International Society for Heart and Lung Transplantation: seventeenth official report- 2000. J Heart Lung Transplant 19, 909, 2000.
3. Bretschneider, H.J. Myocardial protection. Thorac Cardiovasc Surg 28, 295, 1980.
4. Stoica, S.C., Satchithananda, D.K., Dunning, J., Large S.R. Two-decade analysis of cardiac storage for transplantation. Eur J Cardiothorac Surg 20, 792, 2001.
5. Piper, H.M., Meuter, K., Schafer, C. Cellular mechanisms of ischemia-reperfusion injury. Ann Thorac Surg 75, 644, 2003.
6. Alto, L.E., Singal, P.K., Dhalla, N.S. Calcium paradox. Dependence of reperfusion-induced changes on the extracellular calcium concentration. Adv Myocardiol 2, 177, 1980.
7. Stoica, S.C., Satchithananda, D.K., Atkinson, C. The energy metabolism in the right and left ventricles of human donor hearts across transplantation. Eur J Cardiothorac Surg 23,503, 2003.
8. Piper, H.M., Garcia-Dorado, D. Prime causes of rapid cardiomyocyte death during reperfusion. Ann Thorac Surg 68,1913, 1999.
9. Piper, H.M., Abdallah, Y., Schafer, C. The first minutes of reperfusion: a window of opportunity for cardioprotection. Cardiovasc Res 61, 365, 2004.
10. Depre, C., Taegtmeyer, H. Metabolic aspects of programmed cell survival and cell death in the heart. Cardiovasc Res 45,538, 2000.
11. Zhao, Z.Q., Nakamura, M., Wang, N.P. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res 45, 651, 2000.
12. Marten, K., Schmiedl, A., Schnabel, P.A., Richter, J. Structural protection of the myocardial capillary endothelium by different forms of cardiac arrest and subsequent global ischemia at 5 degrees C. Thorac Cardiovasc Surg 47, 205, 1999.
13. Koch,A., Bingold, T.M.,Oberlander, J. Capillary endothelia and cardiomyocytes differ in vulnerability to ischemia=reperfusion during clinical heart transplantation. Eur J Cardiothorac Surg 20, 996, 2001.
14. Kloner, R.A., Ganote, C.E., Jennings, R.B. The ''no-reflow'' phenomenon after temporary coronary occlusion in the dog. J Clin Invest 6, 1496. 1974.
15. Williams, T.J., Snell, G.I. Organ procurement-strategies to optimize donor availability. Semin Respir Crit Care Med 22,541, 2001.
16. Chen, J.M., Russo, M.J., Hammond, K.M. Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann Thorac Surg 80, 224, 2005.
17. Kogure, K., Alonso, O.F. A pictorial representation of endogenous brain ATP by a bioluminescent method. Brain Res 154, 273, 1978.
18. Paschen, W. Imaging of energy metabolites (ATP, glucose and lactate) in tissue sections: a bioluminescent technique. Prog Histochem Cytochem 20, 1, 1990.
19. Aupperle, H., Garbade, J., Ullmann, C. Comparing the ultrastructural effects of two different cardiac preparation- and perfusion-techniques in a porcine model of extracorporal long-term preservation. Eur J Cardiothorac Surg 31, 214, 2007.
20. Hirota, M., Ishino, K., Fukumasu, I. Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors. J Heart Lung Transplant 25, 339, 2006.
21. Jamieson RW. Normothermic organ preservation. Transplant Rev 20, 172, 2006.
22. Schmiedl, A., Schnabel, P.A., Richter, J., Mall, G., Bretschneider, H.J. Preservation of cardiac myocytes subjected to different preconditions: a comparative morphometric study of beating, fibrillating, and cardioplegically arrested canine hearts. Anat Rec 235, 425, 1993.
23. Kloner, R.A., Ganote, C.E., Whalen, D.A., Jennings, R.B. Effect of a transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow. Am J Pathol 74, 399, 1974.
24. Hale, S.L., Kloner, R.A. Role of leukocytes in reperfusion injury. In: Piper H.M., Preusse C.J. Ischemia-Reperfusion in Cardiac Surgery. Dordrecht, Boston, London: Kluwer Academic Publishers 1993, pp. 67-80.
25. Ambrosio, G., Zweier, J.L., Becker, L.C. Apoptosis is prevented by administration of superoxide dismutase in dogswith reperfusedmyocardial infarction.BasicResCardiol93,94,1998.
26. Uraizee, A., Reimer, K.A., Murry, C.E., Jennings, R.B. Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs. Circulation 75, 1237, 1987.
27. Oshima, K., Takeyoshi, I., Mohara, J. Long-term preservation using a new apparatus combined with suppression of pro-inflammatory cytokines improves donor heart function after transplantation in a canine model. J Heart Lung Transplant 24, 602, 2005.