Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction

Basic Research in Cardiology

Volumn 93, Issue 2, 1998, Pages 94-96

  Ambrosio, G ^a   Zweier, J L ^a   Becker, L C ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN RADICAL; SCAVENGER; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOG; HEART INFARCTION; HEART MUSCLE REPERFUSION; NONHUMAN;

ANIMALS; APOPTOSIS; DOGS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; REPERFUSION INJURY; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 0031923944     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950050068     Document Type: Article

References (21)

1. Ambrosio G, Becker LC, Hutchins GM, Weisman HF, Weisfeldt MD (1986) Reduction in experimental infarct size by recombinant human superoxide dismutase: Insights into the pathophysiology of reperfusion injury. Circulation 74: 424-433
2. Ambrosio G, Diana A, Becker LC, Zweier JL, Nicotera P (1994) Oxygen radical generation at reflow may induce apoptosis in postischemic hearts. Circulation 90:1-428 (abstract)
3. Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB (1988) Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J Clin Invest 82: 476-485
4. Bonfoco E, Kraine D, Ankarkrona M, Nicotera P, Lipton SA (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92: 7162-7166
5. Broaddus VC, Yang L, Scavo IM, Ernst JD, Boylan AM (1997) Asbestos induced apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 98: 2050-2059
6. Cheng W, Kajstura J, Nitahara JA, Li B, Reiss K, Liu Y, Clark WA, Krajewski S, Reed JC, Olivetti G, Anversa P (1996) Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res 226: 316-327
7. Fliss H, Gattinger D (1996) Apoptosis in ischemic and reperfused rat myocardium. Circ Res 79: 949-956
8. Gansauge S, Sansauge F, Gause H, Poch B, Schoenberg MH, Berger HG (1997) The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53- and p21 WAF1CIP1 induction. FEBS 404: 10
9. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501
10. Golino P, Ragni M, Cirillo P, Avvedimento VE, Feliciello A, Esposito N, Scognamiglio A, Trimarco B, Iaccarino B, Condorelli M, Chiariello M, Ambrosio G (1996) Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion. Nature Medicine 2: 35-40
11. Gorczyca W, Gong J, Darzynkiewicz Z (1993) Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53: 1945-1951
12. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL (1994) Reperfusion injury induce apoptosis in rabbit cardiomyocytes. J Clin Invest 94: 1621-1628
13. Johnson TM, Yu ZX, Ferrans VJ, Lowenstein RA, Finkel T (1996) Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93: 11848-11852
14. Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajeswki S, Reed JC, Olivette G, Anversa P (1996) Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats. Lab Invest 74: 86-107
15. Kukreja RC, Kontos MC, Loesser KE, Batra SK, Qian YZ, Gbur CJ Jr., Naseem SA, Jesse RL, Hess ML(1994) Oxidant stress increases HSP70 mRNA in isolated perfused rat heart. Am J Physiol 267: H2213-H2219
16. Li PF, Dietz R, von Harsdorf R (1997) Reactive oxygen species induce apoptosis of vascular smooth muscle cell. FEBS Lett 404: 249-252
17. Sasaki H, Matsuno T, Tanaka N, Orita K (1996) Activation of apoptosis during the reperfusion phase after rat liver ischemia. Transplant Proc 28: 1908-1909
18. Schreck R, Rieber P, Bauerle PA (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-I. EMBO J 10: 2247-2258
19. Slater AF, Nobel CS, Orrenius S (1995) The role of intracellular oxidants in apoptosis. Biochim Biophys Acta 127: 59-62
20. Tagami M, Ikeda K, Nara Y, Fujino H, Kubota A, Numano F, Yamori Y (1997) Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats. Lab Invest 76: 613-617
21. Zweier JL, Flaherty JT, Weisfeldt ML (1987) Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA 84: 1404-1407