Structure of human Brn-5 transcription factor in complex with CRH gene promoter

Journal of Structural Biology

Volumn 167, Issue 2, 2009, Pages 159-165

  Pereira, Jose Henrique ^a,b   Kim, Sung Hou ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Brn 5 protein; Crystal structure; POU family; Protein DNA complex; Transcription factors

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN 5; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA PROTEIN COMPLEX; HUMAN; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS;

CORTICOTROPIN-RELEASING HORMONE; CRYSTALLOGRAPHY, X-RAY; HUMANS; POU DOMAIN FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; TRANSCRIPTION FACTORS;

EID: 67649804622     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2009.05.003     Document Type: Article

References (31)

1. Adams P.D., Grosse-Kunstleve R.W., Hung L.-W., Ioerger T.R., McCoy A.J., Moriarty N.W., Read R.J., Sacchettini J.C., Sauter N.K., and Terwilliger T.C. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D 58 (2002) 1948-1954
2. Andersen B., Schonemann M.D., Pearse II R.V., Jenne K., Sugarman J., and Rosenfeld M. Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex. J. Biol. Chem. 268 (1993) 23390-23398
3. Chasman D., Cepek K., Sharp P.A., and Pabo C.O. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. Genes Dev. 13 (1999) 2650-2657
4. Chi Y.-I., Frantz J.D., Oh B.-C., Hansen L., Dhe-Paganon S., and Shoelson S.E. Diabetes mutations delineate an atypical POU domain in HNF-1α. Mol. Cell 10 (2002) 1129-1137
5. Cleary M.A., and Herr W. Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain. Mol. Cell. Biol. 15 (1995) 2090-2100
6. Cleary M.A., Pendergrast P.S., and Herr W. Structural flexibility in transcription complex formation revealed by protein-DNA photocrosslinking. Proc. Natl. Acad. Sci. 94 (1997) 8450-8455
7. Emsley P., and Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60 (2004) 2126-2132
8. Hendrickson W.A. Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science 254 (1991) 51-58
9. Herr W., and Cleary M.A. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9 (1995) 1679-1693
10. Jacobson E.M., Li P., Leon-del-Rio A., Rosenfeld M.G., and Aggarwal A.K. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev. 11 (1996) 198-212
11. Klemm J.D., and Pabo C.O. Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage. Genes Dev. 10 (1996) 27-36
12. Klemm J.D., Rould M.A., Aurora R., Herr W., and Pabo C.O. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77 (1994) 21-32
13. Laughon A. DNA binding specificity of homeodomains. Biochemistry 30 (1991) 11357-11367
14. van Leeuwen H.C., Strating M.J., Rensen M., Laat W., and Vliet P.C. Linker length and composition influence the flexibility of Oct-1 DNA binding. EMBO J. 16 (1997) 2043-2053
15. Li P., He X., Gerrero M.R., Mok M., Aggarwal A., and Rosenfeld M.G. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes Dev. 7 (1993) 2483-2496
16. Lu P., Rha G.B., and Chi Y.I. Structural basis of disease-causing mutations in hepatocyte nuclear factor 1β. Biochemistry 46 (2007) 12071-12080
17. Otwinowski Z., and Minor W. Macromolecular Crystallography. Methods Enzymol. 276 (1997) 307-326
18. Pabo C.O., and Sauer R.T. Transcription factors: structural families and principles of DNA recognition. Annu. Rev. Biochem. 61 (1992) 1053-1095
19. Pabo C.O., Aggardwal A.K., Jordan S.R., Beamer L.J., Obeysekare U.R., and Harrison S.C. Conserved residues make similar contacts in two repressor-operator complexes. Science 247 (1990) 1210-1213
20. Pereira J.H., Ha S.C., and Kim S.-H. Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. Acta Crystallogr. F 64 (2008) 175-178
21. Philips K., and Luisi B. The virtuoso of versatility: POU proteins that flex to fit. J. Mol. Biol. 302 (2000) 1023-1039
22. Reményi A., Tomilin A., Pohl E., Lins K., Philippsen A., Reinbold R., Schöler H.R., and Wilmanns M. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Mol. Cell 8 (2001) 569-580
23. Rhee J.M., Gruber C.A., Brodie T.B., Trieu M., and Turner E.E. Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273 (1998) 34196-34205
24. Rosenfeld M.G. POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev. 5 (1991) 897-907
25. Ruvkun G., and Finney M. Regulation of transcription and cell identity by POU domain proteins. Cell 64 (1991) 475-478
26. Ryan A.F. Transcription factors and the control of inner ear development. Semin. Cell Dev. Biol. 8 (1997) 249-256
27. Studier F.W., Rosenberg A.H., Dunn J.J., and Dubendorff J.W. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185 (1990) 60-89
28. Sturm R.A., and Herr W. The POU domain is a bipartite DNA-binding structure. Nature 336 (1988) 601-604
29. Terwilliger T. SOLVE and RESOLVE: automated structure solution, density modification and model building. J. Synchrotron Radiat. 11 (2004) 49-52
30. Verrijzer C.P., Alkema M.J., van Weperen W.W., Van Leeuwen H.C., Strating M.J., and van der Vliet P.C. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11 (1992) 4993-5003
31. Wu R., Jurek M., Sundarababu S., and Weinstein D.E. The POU Gene Brn-5 is induced by neuregulin and is restricted to myelinating schwann cells. Mol. Cell. Neurosci. 17 (2001) 683-695