Comparison of three vascular endothelial markers in the evaluation of micro vessel density in breast cancer

European Journal of Gynaecological Oncology

Volumn 30, Issue 3, 2009, Pages 285-288

  Da Silva, B B ^a,c   Lopes Costa, P V ^a   Dos Santos, A R ^a   De Sousa Jr , E C ^a   Alencar, A P ^b   Pires, C G ^a   Rosal, M A ^a  

^a FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Jockey Club de Sao Paulo   (Brazil)

Author keywords

Anti CD34, anti CD31; Anti factor VIII; Mammary neoplasia; Microvessel density; Neovascularization

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; CD31 ANTIBODY; CD34 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KRUSKAL WALLIS TEST; MICROVASCULATURE; POSTMENOPAUSE; VASCULAR ENDOTHELIUM;

AGED; AGED, 80 AND OVER; ANTIGENS, CD31; ANTIGENS, CD34; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MICROVESSELS; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; VON WILLEBRAND FACTOR;

EID: 67649789151     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Folkman L: "Role of angiogenesis in tumor growth and metastasis". Semin. Oncol, 2002, 29, 15.
2. Fox S.B., Leek R.D., Weekes M.P., Whitehouse R.M., Gatter K.C., Harris A.L.: "Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis". J. Pathol., 1995, 177, 275.
3. da Silva B.B., de Carvalho Gonçalves Nunes Galvão E.R., Dos Santos L.G.: "Evaluation of CD34 antigen expression following tamoxifen as primary treatment for breast cancer". Int. J. Gynaecol. Obstet., 2006, 93, 70.
4. Ferrara N.: "VEGF as a therapeutic target in cancer". Oncology, 2005, 69, 11.
5. da Silva B.B., da Silva Junior R.G., Borges U.S., da Silveira Filho M.A., Pimentel I.C., Gebrim L.H. et al.: "Quantification of angiogenesis induced in rabbit cornea by breast carcinoma of women treated with tamoxifen". J. Surg. Oncol., 2005, 90, 77.
6. Kerbel R.S.: "Tumor angiogenesis: past, present and the near future". Carcinogenesis, 2000, 21, 505.
7. Vieira S.C., Zeferino L.C., Da Silva B.B., Aparecida Pinto G., Vassallo J., Carasan G.A. et al.: "Quantification of angiogenesis in cervical cancer: a comparison among three endothelial cell markers". Gynecol. Oncol., 2004, 93, 121. (Pubitemid 38429559)
8. Weidner N., Semple J.P., Welch W.R., Folkman J.: "Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma". N. Engl. J. Med., 1991, 324, 1.
9. Weidner N., Folkman J., Pozza F., Bevilacqua P., Allred E.N., Moore D.H. et al.: "Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma". J. Natl. Cancer Inst., 1992, 84, 1875. (Pubitemid 23004615)
10. Kato T., Kameoka S., Kimura T., Nishikawa T., Kobayashi M.: "The combination of angiogenesis and blood vessel invasion as a prognostic indicator in primary breast cancer". Br. J. Cancer, 2003, 88, 1900. (Pubitemid 36829665)
11. Gasparini G., Weidner N., Bevilacqua P., Maluta S., Dalla Palma P. Caffo O. et al.: "Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma". J. Clin. Oncol., 1994, 12, 454. (Pubitemid 24079885)
12. Hall N.R., Fish D.E., Hunt N., Goldin R.D., Guillou P.J., Monson J.R.: "Is the relationship between angiogenesis and metastasis in breast cancer real?". Surg. Oncol., 1992, 1, 223.
13. nd, Thor A.D., Chew K.L., Edgerton S.M. et al.: "Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma". J. Natl. Cancer Inst., 1995, 87, 997.
14. Costello P., McCann A., Carney D.N., Dervan P.A.:"Prognostic significance of microvessel density in lymph node negative breast carcinoma". Hum. Pathol., 1995, 26, 1181.
15. Augustin H.G.: "Antiangiogenic tumour therapy: will it work?". Trends Pharmacol. Sci., 1998, 19, 216.
16. Bottini A., Berruti A., Bersiga A., Brizzi M.P., Allevi G., Bolsi G. et al.: "Changes in microvessel density as assessed by CD34 antibodies after primary chemotherapy in human breast cancer". Clin. Cancer Res., 2002, 8, 1816. (Pubitemid 34633740)
17. Leek R.D.: "The prognostic role of angiogenesis in breast cancer". Anticancer Res., 2001, 21, 4325.
18. Horak E.R., Leek R., Klenk N., LeJeune S., Smith K., Stuart N. et al.: "Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer". Lancet, 1992, 340, 1120.
19. Martin L., Green B., Renshaw C., Lowe D., Rudland P., Leinster S.J. et al.: "Examining the technique of angiogenesis assessment in invasive breast cancer". Br. J. Cancer, 1997, 76, 1046. (Pubitemid 27434662)
20. Heimann R., Ferguson D., Powers C., Recant W.M., Weichselbaum R.R., Hellman S.: "Angiogenesis as a predictor of long-term survival for patients with node-negative breast cancer". J. Natl. Cancer Inst., 1996, 88, 1764. (Pubitemid 26405014)
21. Tas F., Yavuz E., Aydiner A., Saip P., Disci R., Iplikci A. et al.: "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships". Am. J. Clin. Oncol., 2000, 23, 546. (Pubitemid 32429097)
22. Conover W.J.: "Practical Nonparametric Statistics". Second edition, New York, John Wiley & Sons, Inc., 1980.
23. Wang J.M., Kumar S., Pye D., Haboubi N., al-Nakib L.: "Breast carcinoma: comparative study of tumor vasculature using two endothelial cell markers". J. Natl. Cancer Inst., 1994, 86, 386. (Pubitemid 24076881)
24. Parums D.V., Cordell J.L., Micklem K., Heryet A.R., Gatter K.C., Mason D.Y.: "JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections". J. Clin. Pathol., 1990, 43, 752. (Pubitemid 20279705)
25. Uzzan B., Nicolas P., Cucherat M., Perret G.Y.: "Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis". Cancer Res., 2004, 64, 2941. (Pubitemid 38581387)
26. Siitonen S.M., Haapasalo H.K., Rantala I.S., Helin H.J., Isola J.J.: "Comparison of different immunohistochemical methods in the assessment of angiogenesis: lack of prognostic value in a group of 77 selected node-negative breast carcinomas". Mod. Pathol., 1995, 8, 745.
27. Goulding H., Abdul Rashid N.F., Robertson J.F., Bell J.A., Elston C.W., Blarney R.W. et al.: "Assessment of angiogenesis in breast carcinoma: an important factor in prognosis?". Hum. Pathol., 1995, 26, 1196.
28. Kuzu I., Bicknell R., Harris A.L., Jones M., Gatter K.C., Mason D.Y.: "Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours". J. Clin. Pathol., 1992, 45, 143.
29. Albelda S.M., Muller W.A., Buck C.A., Newman P.J.: "Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule". J. Cell. Biol., 1991, 114, 1059. (Pubitemid 21909867)