Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome

Critical Care Medicine

Volumn 37, Issue 7, 2009, Pages 2228-2234

  Thal, Serge C ^a,b   Sporer, Sonja ^a   Schmid Elsaesser, Robert ^a   Plesnila, Nikolaus ^a   Zausinger, Stefan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

B2 receptor; Bradykinin; Kallikrein kinin system; Rat; Subarachnoid Hemorrhage

Indexed keywords

ANATIBANT; BRADYKININ B2 RECEPTOR; KALLIKREIN; KININOGEN; MESSENGER RNA; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERFORATION; BODY WEIGHT; BRAIN CIRCULUS ARTERIOSUS; BRAIN EDEMA; BRAIN FUNCTION; BRAIN WATER; CONTROLLED STUDY; GENE EXPRESSION; INTRACRANIAL PRESSURE; LASER DOPPLER FLOWMETRY; LEFT HEMISPHERE; MALE; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RIGHT HEMISPHERE; SUBARACHNOID HEMORRHAGE; ANIMAL; BRAIN CIRCULATION; CONVALESCENCE; DISEASE MODEL; DRUG ADMINISTRATION; DRUG ANTAGONISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN EDEMA; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; INTRACRANIAL PRESSURE; LASER-DOPPLER FLOWMETRY; MALE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B2; RECOVERY OF FUNCTION; SUBARACHNOID HEMORRHAGE;

EID: 67649760757     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181a068fc     Document Type: Article

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