Podoplanin expression in fibrous histiocytomas and cellular neurothekeomas

American Journal of Dermatopathology

Volumn 31, Issue 2, 2009, Pages 137-139

  Kaddu, Steven ^a   Leinweber, Bernd ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Cellular neurothekeoma; D2 40; Dermal nerve sheath myxoma; Dermatofibrosarcoma protuberans; Fibrous histiocytoma; Plexiform fibrohistiocytic tumor; Podoplanin

Indexed keywords

PODOPLANIN; ANTIBODY; DIAGNOSTIC AGENT; MEMBRANE PROTEIN; PDPN PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CONTROLLED STUDY; DERMATOFIBROMA; DERMATOFIBROSARCOMA PROTUBERANS; DIFFERENTIAL DIAGNOSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MESENCHYMOMA; MYXOMA; NEUROTHEKEOMA; PLEXIFORM FIBROHISTIOCYTIC TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; IMMUNOLOGY; MALIGNANT FIBROUS HISTIOCYTOMA; METABOLISM; PATHOLOGY; SKIN TUMOR;

ANTIBODIES; DERMATOFIBROSARCOMA; DIAGNOSIS, DIFFERENTIAL; HISTIOCYTOMA, MALIGNANT FIBROUS; HUMANS; MEMBRANE GLYCOPROTEINS; NEUROTHEKEOMA; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 67649667162     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e31819821c7     Document Type: Article

References (25)

1. Schacht V, Dadras SS, Johnson LA, et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005;166: 913-921.
2. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries. Am J Pathol. 1999;154:385-394.
3. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15:434-440.
4. Franke FE, Steger K, Marks A, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol. 2004;31:362-367.
5. Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumors. Histopathology. 2005;46:396-402.
6. Ordón̂ez NG. Podoplanin: a novel diagnostic immunohistochemical marker. Adv Anat Pathol. 2006;13:83-88.
7. Gomaa AH, Yaar M, Bhawan J. Cutaneous immunoreactivity of D2-40 antibody beyond the lymphatics. Am J Dermatopathol. 2007;29:18-21.
8. Hansen T, Katenkamp K, Bittinger F, et al. D2-40 labeling in lymphangiomyoma/lymphangiomyomatosis of the soft tissue: further evidence of lymphangiogenic tumor histogenesis. Virchows Arch. 2007; 450:449-453.
9. Liang H, Wu H, Giorgadze TA, et al. Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol. 2007;31:304-310.
10. Jokinen CH, Dadras SS, Goldblum JR, et al. Diagnostic implications of podoplanin expression in peripheral nerve sheath neoplasms. Am J Clin Pathol. 2008;129:886-893.
11. Chan LJ, Xu XW, Zhang PJ. D2-40 is another useful marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans. Mod Pathol. 2007;20:91A.
12. Calonje E, Wilson-Jones E, Smith NP, et al. Cellular neurothekeoma: an epithelioid variant of pilar leiomyoma? Morphological and immunohis-tochemical analysis of a series. Histopathology. 1992;20:397-404.
13. Sachdev R, Sundram UN. Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma. Am J Clin Pathol. 2006;126:554-563.
14. Ma CK, Zarbo RJ, Gown AM. Immunohistochemical characterization of atypical fibroxanthoma and dermatofibrosarcoma protuberans. Am J Clin Pathol. 1992;97:478-483.
15. Mahalingam M, LoPiccolo D, Byers HR. Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases. J Cutan Pathol. 2001;28:282-286.
16. Wang AR, May D, Bourne P, et al. PGP9.5: a marker for cellular neurothekeoma. Am J Surg Pathol. 1999;23:1401-1407.
17. Fullen DR, Lowe L, Su LD. Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma. J Cutan Pathol. 2003; 30:118-122.
18. Campbell LK, Thomas JR, Lamps LW, et al. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Mod Pathol. 2003;16:963-969.
19. Böni R, Burg G, Doguoglu A, et al. Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. Br J Dermatol. 1997;137:39.
20. Schacht V, Ramirez MI, Hong YK, et al. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003;22:3546-3556.
21. Fetsch JF, Laskin WB, Hallman JR, et al. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007;31:1103-1114.
22. Hornick JL, Fletcher CD. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol. 2007;31:329-340.
23. Mentzel T, Calonje E, Fletcher CD. Dermatomyofibroma: additional observations on a distinctive cutaneous myofibroblastic tumour with emphasis on differential diagnosis. Br J Dermatol. 1993;129:69-73.
24. Kuroda K, Tajima S. Proliferation of HSP47-positive skin fibroblasts in dermatofibroma. J Cutan Pathol. 2008;35:21-26.
25. de Feraudy S, Mar N, McCalmont TH. Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma. Am J Surg Pathol. 2008;32:1111-1122.