Do androgens have a direct effect on endometrial function? An in vitro study

Fertility and Sterility

Volumn 74, Issue 4, 2000, Pages 771-779

  Tuckerman, Elizabeth M ^a,b   Okon, Marcus A ^b   Li, Tin Chiu ^a,b   Laird, Susan M ^a  

^a JESSOP HOSPITAL FOR WOMEN   (United Kingdom)

^b SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

Androgens; Cell culture; Cell proliferation; Endometrium; Glycodelin A

Indexed keywords

ANDROGEN; ANDROSTANOLONE; ANDROSTENEDIONE; CYPROTERONE ACETATE; KI 67 ANTIGEN; PLACENTA PROTEIN 14; PRASTERONE; TESTOSTERONE;

ADULT; ARTICLE; DNA SYNTHESIS; ENDOMETRIUM; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

ANDROGENS; ANDROSTENEDIONE; ANIMAL; BIOLOGICAL MARKERS; CELLS, CULTURED; CYPROTERONE ACETATE; ENDOMETRIUM; EPITHELIAL CELLS; FEMALE; GLYCOPROTEINS; HUMAN; IN VITRO; KI-67 ANTIGEN; MICE; OUTCOME ASSESSMENT (HEALTH CARE); PRASTERONE; PREGNANCY PROTEINS; RADIOIMMUNOASSAY; STANOLONE; SUPPORT, NON-U.S. GOV'T; TESTOSTERONE; THYMIDINE;

EID: 0033804845     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(00)00711-1     Document Type: Article

References (19)

1. Okon M.A., Laird S.M., Tuckerman E.M., Li T.C. Serum androgen levels in women who suffer recurrent miscarriage and their correlation with markers of endometrial function. Fertil Steril. 69:1998;682-690.
2. Tulppala M., Stenman U.H., Cacciatore B., Ylikorkala O. Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage prospective study in 50 women . Br J Obstet Gynaecol. 100:1993;348-352.
3. Homburg R., Eshel A., Kilborn J. Combined luteinizing hormone releasing hormone analogue and exogenous gonadotrophins for the treatment of infertility associated with polycystic ovaries. Hum Reprod. 5:1990;32-35.
4. Bussen S., Sütterlin M., Steck T. Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion. Hum Reprod. 14:1999;18-20.
5. Dalton C.F., Laird S.M., Serle E., Saravelos H., Warren M.A., Li T.C., et al. The measurement of CA 125 and placental protein 14 in uterine flushings in women with recurrent miscarriage relation to endometrial morphology . Hum Reprod. 10:1995;2680-2684.
6. Mackenna A., Li T.C., Dalton C., Bolton A.E., Cooke I.D. Placental protein 14 levels in uterine flushing and plasma of women with unexplained infertility. Fertil Steril. 59:1993;577-582.
7. Li T.C., Dalton C., Hunjan K.S., Bolton A.E., Warren M.A. The correlation of endometrial PP14 concentrations in uterine flushing and endometrial morphology in the peri-implantation period. Hum Reprod. 8:1993;1923-1927.
8. Laird S.M., Li T.C., Bolton A.E. The production of placental protein 14 and interleukin 6 by human endometrial cells in culture. Hum Reprod. 8:1993;793-798.
9. Laird S.M., Tuckerman E., Li T.C., Bolton A.E. Stimulation of endometrial epithelial cell interleukin 6 (IL6) production by interleukin 1 and placental protein 14. Hum Reprod. 9:1994;1339-1343.
10. Horie K., Takakura K.K., Imai K., Liao S., Mori T. Immunohistochemical localisation of androgen receptor in the human endometrium, decidua, and placenta and pathological conditions of the endometrium. Hum Reprod. 7:1992;1461-1466.
11. Mertens H.J., Heineman M.J., Koudstaal J., Theunissen P., Evers J.L. Androgen receptor content in human endometrium. Eur J Obstet Gynaecol Reprod Biol. 70:1996;3-11.
12. Narukawa S, Kanzaki H, Inoue T, Imai K, Higuchi T, Hatayama H, et al. Androgens induce prolactin production by human endometrial stromal cells in vitro. J Clin Endocrinol Metab 1994;78:165-8.
13. Laird SM, Tuckerman EM, Li T C, Saravelos H. The production of tumour necrosis factor alpha (TNF-alpha) by human endometrial cells in culture. Hum Reprod 1996;11:1318-23.
14. Seppala M., Koistinen R., Rutanen E.M. Uterine endocrinology and paracrinology insulin growth factor binding protein-1 and placental protein 14 revisited . Hum Reprod. 9:1994;917-925.
15. Klentzeris L.D., Bulmer J.N., Seppala M., Li T.C., Warren M.A., Cooke I.D. Placental protein 14 in cycles with normal and retarded endometrial differentiation. Hum Reprod. 9:1994;394-398.
16. Iwai M., Kanzaki H., Fujimoto M., Kojima K., Hatayama H., Inoue T., et al. Regulation of sex steroid receptor gene expression by progesterone and testosterone in cultured human endometrial stromal cells. J Clin Endocrinol Metab. 80:1995;450-454.
17. Xiao C.W., Goff A.K. Differential effects of oestradiol and progesterone on proliferation and morphology of cultured bovine uterine epithelial and stromal cells. J Reprod Fertil. 112:1998;315-324.
18. Watson H., Franks S., Bonney R.C. Regulation of epidermal growth factor receptor by androgens in human endometrial cells in culture. Hum Reprod. 13:1998;2585-2592.
19. Rose G.L., White J.O., Dowsett M. The inhibitory effects of danazol, danazol metabolites, gestrinone, and testosterone on the growth of human endometrial cells in vitro. Fertil Steril. 49:1998;224-228.