Erythrocyte folate and 5-methyltetrahydrofolate levels decline during 6 months of oral anticoagulation with warfarin

Blood Coagulation and Fibrinolysis

Volumn 20, Issue 4, 2009, Pages 297-302

  Sobczyh́ska Malefora, Agata ^a,d   Harrington, Dominic J ^a   Lomer, Miranda C E ^b,c   Pettitt, Claire ^c   Hamilton, Sophie ^c   Rangarajan, Savita ^a   Shearer, Martin J ^a  

^a Centre for Haemostasis and Thrombosis   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Anticoagulation; Folate; Methyttetrahydrofolate; Vitamin K; Warfarin

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID; PHYTOMENADIONE; WARFARIN;

ANTICOAGULANT THERAPY; ARTICLE; BLOOD SAMPLING; DIETARY INTAKE; ERYTHROCYTE; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRACTICE GUIDELINE; PRIORITY JOURNAL; TREATMENT DURATION; UNITED KINGDOM; VITAMIN BLOOD LEVEL; VITAMIN K METABOLISM;

ADMINISTRATION, ORAL; ADULT; ANTICOAGULANTS; DIETARY SUPPLEMENTS; ERYTHROCYTES; FEMALE; FOLIC ACID; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; TETRAHYDROFOLATES; THROMBOEMBOLISM; TIME FACTORS; VITAMIN K; VITAMINS; WARFARIN;

EID: 67649547027     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32832aa6a1     Document Type: Article

References (42)

1. Hirsh J, Fuster V, Ansell J, Halperin JL American Heart Association/ American College of Cardiology Foundation guide to warfarin therapy. Circulatio. 2003; 107:1692-1711.
2. Baglin TP, Cousins D, Keeling DM, Perry DJ, Watson HG. Safety indicators for inpatient and outpatient oral anticoagulant care: recommendations from the British Committee for Standards in Haematology and National Patient Safety Agency. Br J Haemato. 2007; 136:26-29.
3. Franco V, Polanczyk CA, Clausell N, Rohde LE. Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols. Am J Me. 2004; 116:651 -656.
4. Pedersen FM, Hamberg O, Hess K, Ovesen L The effect of dietary vitamin Kon warfarin-induced anticoagulation. J Intern Me. 1991; 229:517-520.
5. Sconce E, Khan T, Mason J, Noble F, Wynne H, Kamali F. Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation. Thromb Haemos. 2005; 93:872-875.
6. Bolton-Smith C, Price RJG, Fenton ST, Harrington DJ, Shearer MJ. Compilation of a provisional UK database for the phylloquinone (vitamin K,) content of foods. Br J Nut. 2000; 83:389-399.
7. Murua A, Quintana I, Galarza C, Alfie J, Kordich L Unsuspected hyperhomocysteinemia in chronically anticoagulated patients. 6/ood Coagul Fibrinolysi. 2001; 12:79-80.
8. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nut. 2001; 73:613-621.
9. Oger E, Lacut K, Le Gal G, Couturaud F, Guenet D, Abalain JH, et al. Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study - a hospital-based case-control study. J Thromb Haemos. 2006; 4:793-799.
10. Wald DS, Wald NJ, Morris JK, Law M. Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BM. 2006; 333:1114-1117.
11. Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nut. 2006; 136:1731S-1740S.
12. Quere I, Perneger TV, Zittoun J, Bellet H, Gris JC, Daures JP, et al. Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study. Lance. 2002; 359:747-752.
13. Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CM, Duran M, et al. Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J Nut. 1999; 129:1135-1139.
14. Fiskerstrand T, Refsum H, Kvalheim G, Ueland PM. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Che. 1993; 39:263-271.
15. Babidge PJ, Babidge WJ. Determination of methylmalonic acid by high-performance liquid chromatography. Anal Bioche. 1994; 216:424-426.
16. Davidson KW, Sadowski JA. Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods Enzymo. 1997; 282:408-421.
17. McCarthy PT, Harrington DJ, Shearer MJ. Assay of phylloquinone in plasma by high-performance liquid chromatography with electrochemical detection. Methods Enzymo. 1997; 282:421 -433.
18. Chladek J, Sispera L, Martinkova J. High-performance liquid chromatographic assay for the determination of 5-methyltetrahydrofolate in human plasma. J Chromatogr B Biomed Sci App. 2000; 744:307-313.
19. Pfeiffer CM, Fazili Z, McCoy L, Zhang M, Gunter EW. Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay. Clin Che. 2004; 50:423-432.
20. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and clinical applications. Clin Che. 1993; 39:1764-1779.
21. Bingham SA, Gill C, Welch A, Cassidy A, Runswick SA, Oakes S, ef al. Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-h urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. Int J Epidemio. 1997; 26 (Suppl 1):S137-S151.
22. Nelson M, Atkinson M, Meyer J. A Photographic atlas of food portion sizes. London: MAFF; 1997.
23. Lomer MC, Kodjabashia K, Hutchinson C, Greenfield SM, Thompson RP, Powell JJ. Intake of dietary iron is low in patients with Crohn's disease:
24. a case-control study. Br J Nut. 2004; 91:141 -148.
25. Thane CW, Paul AA, Bates CJ, Bolton-Smith C, Prentice A, Shearer MJ. Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people. Br J Nut. 2002; 87:605-613.
26. Thane CW, Bolton-Smith C, Coward WA. Comparative dietary intake and sources of phylloquinone (vitamin K1) among British adults in 1986-7 and 2000-1. Br J Nutr 200.; 96:1105-1115.
27. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemio. 1986; 124:17-27.
28. Department of Health. Dietary reference values for food energy and nutrients for the United Kingdom. Report on Health and Social Subjects 41. London, UK; 1991.
29. Henderson L, Irving K, Gregory J, Bates CJ, Prentice A, Perks J, et al. The National Diet and Nutrition Survey: adults aged 19 to 64 years. Vitamin and mineral intake and urinary analytes. London: The Stationery Office; 2003
30. Fazili Z, Pfeiffer CM, Zhang M. Comparison of serum folate species analyzed by LC-MS/MS with total folate measured by microbiologic assay and Bio-Rad radioassay. Clin Che. 2007; 53:781-784.
31. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. Washington DC: National Academy Press; 1998.
32. Quintana I, Murua A, Crisp R, Porterie P, Korin J, Gioseffi O, era/. Folic acid and homocysteine levels in chronically anticoagulated patients. Supp J Thromb Haemos. 2001; 12:79-80.
33. Sobczynska-Malefora A, Harrington DJ, Rangarajan S, Kovacs JA, Shearer MJ, Savidge GF. Hyperhomocysteinemia and B-vitamin status after discontinuation of oral anticoagulation therapy in patients with a history of venous thromboembolism. Clin Chem Lab Me. 2003; 41:1493-1497.
34. Golbahar J, Aminzadeh MA, Sharifkazemi MB, Rezaian GR. Association of red blood cell 5-methyltetrahydrofolate and severity of coronary artery disease: a cross-sectional study from Shiraz, southern Iran. Heart Vessel. 2005; 20:203-206.
35. Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, et al. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulatio. 2006; 114:1193-1201.
36. Dudman NP. An alternative view of homocysteine. Lance. 1999; 354:2072-2074.
37. Thane CW, Bates CJ, Shearer MJ, Unadkat N, Harrington DJ, Paul AA, et al. Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people. Br J Nut. 2002; 87:615-622.
38. Booth SL, Sokoll U, O'Brien ME, Tucker K, Dawson-Hughes B, Sadowski JA. Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women. Eur J Clin Nut. 1995; 49:832-841.
39. Shearer MJ, Harrington DJ, Bolton-Smith C, Clark KGA, Savidge GF. A very low, fixed dose of warfarin has a minimal effect on the gamma-carboxylation of the vitamin K-dependent coagulation factors but perturbs vitamin K metabolism [abstract]. Suppl J Thromb Haemos. 1997:708.
40. Lamon-Fava S, Sadowski JA, Davidson KW, O'Brien ME, McNamara JR, Schaefer EJ. Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans. Am J Clin Nut. 1998; 67:1226-1231.
41. Sconce E, Avery P, Wynne H, Kamali F. Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin. Bloo. 2007; 109:2419-2423.
42. Rombouts EK, Rosendaal FR, Van Der Meer FJ. Daily vitamin K supplementation improves anticoagulant stability. J Thromb Haemos. 2007; 5:2043-2048.