Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis

International Journal of Molecular Medicine

Volumn 23, Issue 6, 2009, Pages 717-723

  Huang, Qian ^a   Xie, Qing ^a   Shi, Cui Cui ^a   Xiang, Xiao Gang ^a   Lin, Lan Yi ^a   Gong, Bang Dong ^a   Zhao, Gang De ^a   Wang, Hui ^a   Jia, Ni Na ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Angiotensin; Angiotensin converting enzyme 2; Angiotensin II; Liver fibrosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ANGIOTENSIN CONVERTING ENZYME 2; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; DIPEPTIDYL CARBOXYPEPTIDASE; EOSIN; HEMATOXYLIN; MESSENGER RNA; OLIVE OIL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; IN VIVO STUDY; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STAINING; TISSUE DISTRIBUTION;

ANIMALS; BLOTTING, WESTERN; CARBON TETRACHLORIDE; LIVER; LIVER CIRRHOSIS; MALE; PEPTIDYL-DIPEPTIDASE A; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 67649496959     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000185     Document Type: Article

References (36)

1. Bataller R, Gines P, Nicolas JM, Gorbig MN, Garcia Ramallo E, Gasull X, Bosch J, Arroyo V and Rodes J: Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology 118: 1149-1156, 2000.
2. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ and Brenner DA: NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 112: 1383-1394, 2003.
3. Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Yanase K, Namisaki T, Yamazaki M, Tsujinoue H, Imazu H and Fukui H: Angiotensin-II induces the tissue inhibitor of metalloproteinases-1 through the protein kinase-C signaling pathway in rat liver fibrosis development. Hepatol Res 27: 51-56, 2003.
4. Bataller R, Gabele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA and Rippe RA: Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct ligated rats. Hepatology 41: 1046-1055, 2005.
5. Croquet V, Moal F, Veal N, Wang J, Oberti F, Roux J, Vuillemin E, et al: Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension. J Hepatol 37: 773-780, 2002.
6. Jonsson JR, Clouston AD, Ando Y, Kelemen LI, Horn MJ, Adamson MD, Purdie DM and Powell EE: Angiotensin converting enzyme inhibition attenuates the progression of rat hepatic fibrosis. Gastroenterology 121: 148-155, 2001.
7. Kurikawa N, Suga M, Kuroda S, Yamada K and Ishikawa H: An angiotensin II type 1 receptor antagonist, olmesartan medoxomil, improves experimental liver fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells. Br J Pharmacol 139: 1085-1094, 2003.
8. Yang L, Bataller R, Dulyx J, Coffman TM, Gines P, Rippe RA and Brenner DA: Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 43: 317-323, 2005.
9. Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Nakatani T, Tsujinoue H and Fukui H: Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats. Hepatology 34: 745-750, 2001.
10. Ferrario CM, Chappell MC, Tallant EA, et al: Counterregulatory actions of angiotensin-(1-7). Hypertension 30: 535-541, 1997.
11. Burrell LM, Johnston CI, Tikellis C, et al: ACE2, a new regulator of the rennin angiotensin system. Trends Endocrinol Metab 15: 166-169, 2004.
12. Yagil Y and Yagil C: Hypothesis: ACE2 modulates blood pressure in the mammalian organism. Hypertension 41: 871-873, 2003.
13. Crackower MA, Sarao R, Oudit GY, et al: Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417: 822-828, 2002.
14. Tikellis C, Johnston CI, Forbes J, et al: Characterisation of renal angiotensin converting enzyme 2 in diabetic nephropathy. Hypertension 41: 392-397, 2003.
15. Li W, Moore MJ, Vasilieva N, et al: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426: 450-454, 2003.
16. Dimitrov DS: The secret life of ACE2 as a receptor for the SARS virus. Cell 115: 652-653, 2003.
17. Paizis G, Tikellis C, Cooper ME, Schembri JM, Lew RA, Smith AI, et al: Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut 54: 1790-1796, 2005.
18. Ishak K, Baptista A, Bianchi L, Callea F, De Grote J, Gudat F, et al: Histologic grading and staging of chronic hepatitis. J Hepatol 22: 696-699, 1995.
19. Paizis G, Gilbert RE, Cooper ME, et al: Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis. J Hepatol 35: 376-385, 2001.
20. Paizis G, Cooper ME, Schembri JM, et al: Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver. Gastroenterology 123: 1667-1676, 2002.
21. Bataller R, Sancho-Bru P, Gines P, et al: Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 125: 117-125, 2003.
22. Santos RAS, Simo es e Silva AC, Maric C, Silva DMR, Machado RP, Buhr I, et al: Angiotensin-(1-7) is an endogenous ligand for the G-protein coupled receptor Mas. Proc Natl Acad Sci USA 100: 8258-8263, 2003.
23. Donoghue M, Hsieh F, Baronas E, et al: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 87: E1-E9, 2002.
24. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G and Turner AJ: A human homolog of angiotensin-converting enzyme: loning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 275: 33238-33243, 2000.
25. Harmer D, Gilbert M, Borman R, et al: Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett 532: 107-110, 2002.
26. Lee JK, Hsieh JF, Tsai SC, Ho YJ and Kao CH: Effects of single dose of 50 mg captopril in patients with liver cirrhosis and ascitis. Hepato-Gastroenterology 47: 767-770, 2000.
27. Yoshiji H, Yoshii J, Ikenaka Y, Noguchi R, Tsujinoue H, Nakatani T, Imazu H, Yanase K, Kuriyama S and Fukui H: Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. J Hepatol 37: 22-30, 2002.
28. Terui Y, Saito T, Watanabe H, Togashi H, Kawata S, Kamada Y and Sakuta S: Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C. Hepatology 36: 1022, 2002.
29. Ohishi T, Saito H, Tsusaka K, Toda K, Inagaki H, Hamada Y, Kumagai N, Atsukawa K and Ishii H: Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats. Hepatol Res 21: 147-158, 2001.
30. Zisman LS, Meixell GE, Bristow MR and Canver CC: Angiotensin-(1-7) formation in the intact human heart: in vivo dependence on angiotensin II as substrate. Circulation 108: 1679-1681, 2003.
31. Santos RA and Ferreira AJ: Angiotensin-(1-7) and the rennin angiotensin system. Curr Opin Nephrol Hypertens 16: 122-128, 2007
32. Pereira RM, Dos Santos RA, Teixeira MM, et al: The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of Angiotensin1-7. J Hepatol 46: 674-681, 2007.
33. Huentelman MJ, Grobe JL, Vazquez J, et al: Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Exp Physiol 90: 783-790, 2005.
34. Diez-Freire C, Vazquez J, Correa de Adjounian MF, et al: ACE2 gene transfer attenuates hypertension linked pathophysiological changes in the SHR. Physiol Genomics 27: 12-19, 2006.
35. Lambert DW, Yarski M, Warner FJ, Thornhill P, Parkin ET, Smith AI, et al: Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem 280: 30113-30119, 2005.
36. Dales NA, Gould AE, Brown JA, et al: Substrate-based design of the first class of angiotensin converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc 124: 11852-11853, 2002.