Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations

British Journal of Nutrition

Volumn 101, Issue 3, 2009, Pages 317-321

  Maurois, Pierre ^a,b   Pages, Nicole ^c   Bac, Pierre ^a,b   German Fattal, Michèle ^a,b   Agnani, Geneviève ^a   Delplanque, Bernadette ^a   Durlach, Jean ^d   Poupaert, Jacques ^e   Vamecq, Joseph ^f  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^f INSERM   (France)

Author keywords

Audiogenic seizures; Ebselen; Magnesium chloride hexahydrate; N methyl D aspartate receptor; N methyl D aspartate induced seizure; Nutritional magnesium deprivation; Seizure threshold

Indexed keywords

EBSELEN; MAGNESIUM CHLORIDE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRUG DOSE INCREASE; MAGNESIUM DEFICIENCY; MOUSE; NONHUMAN; SEIZURE; SINGLE DRUG DOSE; TOXICITY TESTING;

ACOUSTIC STIMULATION; ANIMALS; ANTIOXIDANTS; AZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; MAGNESIUM; MAGNESIUM DEFICIENCY; MICE; N-METHYLASPARTATE; ORGANOSELENIUM COMPOUNDS; SEIZURES;

ANIMALIA; MUS;

EID: 67649443838     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508006752     Document Type: Article

References (30)

1. Nowak L, Bregestovski P, Ascher P, Herbet A & Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307, 462-465.
2. Durlach J, Bac P, Bara M & Guiet-Bara A (2000) Physiopathology of symptomatic and latent forms of central nervous hyperexcitability due to magnesium deficiency: A current general scheme. Magnes Res 13 293-302.
3. Bac P, Maurois P, Dupont C, Pages N, Stables JP, Gressens P, Evrard P & Vamecq J (1998) Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: A nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties. J Neurosci 18, 4363-4373.
4. Maurois P, Rocchi S, Pages N, Bac P, Stables JP, Gressens P & Vamecq J (2008) The PPARγ agonist FMOC-L-leucine protects both mature and immature brain. Biomed Pharmacother 62, 259-263.
5. Vamecq J, Maurois P, Bac P, Bailly F, Bernier JL, Stables JP, Husson I & Gressens P (2003) Potent mammalian cerebro-protection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols. Eur J Neurosci 18, 1110-1120.
6. Bussière FI, Tridon A, Zimowska W, Mazur A & Rayssiguier Y (2003) Increase in complement component C3 is an early response to experimental magnesium deficiency in rats. Life Sci 73, 499-507.
7. Maurois P, Gueux E & Rayssiguier Y (1989) Protective effect of severe magnesium deficiency on Plasmodium chabaudi infection. Magnes Res 2, 183-187.
8. Maurois P, Delcourt PH, Gueux E & Rayssiguier Y (1994) Magnesium deficiency protects against Babesia hylomysci and mice become resistant to rechallenge with the parasite regardless of diet fed. Parasitology 108, 245-248.
9. Busserolles J, Gueux E, Rock E, Mazur A & Rayssiguier Y (2003) High fructose feeding of magnesium deficient rats is associated with increased plasma triglyceride concentration and increased oxidative stress. Magnes Res 16, 7-12.
10. Herin GA, Du S & Aizenman E (2001) The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site. J Neurochem 78, 1307-1314.
11. Green AR & Ashwood T (2005) Free radical trapping as a therapeutic approach to neuroprotection in stroke: Experimental and clinical studies with NXY-059 and free radical scavengers. Curr Drug Targets CNS Neurol Disord 4, 109-118.
12. Bhudia S, Cosgrove D, Naugle R, et al. (2006) Magnesium as a neuroprotectant in cardiac surgery: A randomized clinical trial. J Thorac Cardiovasc Surg 131, 853-861.
13. Chan MT, Boet R, Ng SC, Poon WS & Gin T (2005) Magnesium sulfate for brain protection during temporary cerebral artery occlusion. Acta Neurochir 95, Suppl., 107-111.
14. Wong GK, Chan MT, Poon WS, Boet R & Gin T (2006) Magnesium therapy within 48 hours of an aneurysmal subarachnoid hemorrhage: Neuro-panacea. Neurol Res 28, 431-435.
15. Pierson MG & Swann JW (1988) The sensitive period and optimum dosage for induction of audiogenic seizure susceptibility by kanamycin in the Wistar rat. Hear Res 32, 1-10.
16. Kawai K, Penix LP, Kawahara N, Ruetzler CA & Klatzo I (1995) Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats. J Cereb Blood Flow Metab 15, 248-258.
17. Schurr A, Payne RS, Reid KH, Iyer V, Tseng MT, Li MM, Chan SA, Young C, Miller JJ & Rigor BM (1995) Cardiac arrest-induced global ischemia studied in vitro. Life Sci 57, 2425-2430.
18. Kumaran C & Shivakumar K (2001) Superoxide-mediated activation of cardiac fibroblasts by serum factors in hypomagnesemia. Free Radic Biol Med 31, 882-886.
19. Moro MA, Almeida A, Bolaños JP & Lizasoain I (2005) Mitochondrial respiratory chain and free radical generation in stroke. Free Radic Biol Med 39, 1291-1304.
20. Regan RF & Guo Y (2001) Magnesium deprivation decreases cellular reduced glutathione and causes oxidative neuronal death in murine cortical cultures. Brain Res 890, 177-183.
21. Sugawara T & Chan PH (2003) Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 5 597-607.
22. Takayama M, Yamane H, Konishi K, Iguchi H, Shibata S, Sunami K, Nakai Y & Nakagawa T (1997) Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Acta Otolaryngol 528, Suppl., 19-24.
23. Zhou Q, Olinescu RM & Kummeraw FA (1999) Influence of low magnesium concentrations in the medium on the antioxidant system in cultured human arterial endothelial cells. Magnes Res 12, 19-29.
24. Yamasoba T, Pourbakht A, Sakamoto T & Suzuki M (2005) Ebselen prevents noise-induced excitotoxicity and temporary threshold shift. Neurosci Lett 380, 234-238.
25. Pages N, Maurois P, Agnani G, Vamecq J, Fénart E, Bac P & Delplanque B (2007) Is chronic rapeseed oil diet more neuroprotective than chronic corn/sunflower diet? Evaluation by audiogenic seizure test in magnesium-deficient mice (MDDAS). OCL (Oléagineux, Corps gras & Lipides) 14, 214-215.
26. Mazur A, Maier JA, Rock E, Gueux E, Nowacki W & Rayssiguier Y (2007) Magnesium and the inflammatory response: Potential physiopathological implications. Arch Biochem Biophys 458, 48-56.
27. Hsu JM, Rubenstein B & Paleker AG (1982) Role of magnesium in glutathione metabolism of rat erythrocytes. J Nutr 112, 488-496.
28. Mills BJ, Lindeman RD & Lang CA (1986) Magnesium deficiency inhibits biosynthesis of blood glutathione and tumor growth in the rat. Proc Soc Exp Biol Med 181, 326-332.
29. Heinrich PC, Steffen H, Jauser P & Wiss O (1972) Studies on the reconstitution of apotransketolase with thiamin pyrophosphate and analogs of the coenzyme. Eur J Biochem 30, 533-541.
30. Veronese FM, Boccu E, Fontana A, Benassi CA & Scoffone E (1974) Isolation and some properties of 6-phosphogluconate dehydrogenase from Bacillus stearothermophilus. Biochim Biophys Acta 334, 31-44.